Calcineurin-mediated dephosphorylation of c-Jun Ser-243 is required for c-Jun protein stability and cell transformation

Oncogene

Volumn 27, Issue 17, 2008, Pages 2422-2429

  Huang, C C ^a   Wang, J M ^a,b   Kikkawa, U ^c   Mukai, H ^c   Shen, M R ^a,b   Morita, I ^d   Chen, B K ^a,b   Chang, W C ^a,b,e  

^a Institute of Biomedical Science   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c KOBE UNIVERSITY   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^e NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

c jun; Calcineurin; Cell transformation; Dephosphorylation

Indexed keywords

CALCINEURIN; CALMODULIN BINDING PROTEIN; MUTANT PROTEIN; PROTEIN C JUN; SERYLTHREONINE PHOSPHATASE CALCINEURIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELL TRANSFORMATION; FEMALE; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION; HALF LIFE TIME; HUMAN; HUMAN CELL; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN STABILITY; UBIQUITINATION; UTERINE CERVIX CANCER; WILD TYPE;

ANIMALS; CALCINEURIN; CELL LINE; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; HUMANS; MUTATION; PHOSPHOSERINE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-JUN; TRANSGENES;

EID: 42049106500     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1210888     Document Type: Article

References (22)

1. Amuthan G, Biswas G, Ananadatheerthavarada HK, Vijayasarathy C, Shephard HM, Avadhani NG. (2002). Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene 21: 7839-7849.
2. Bos TJ, Monteclaro FS, Mitsunobu F, Ball Jr AR, Chang CH, Nishimura T et al. (1990). Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences. Genes Dev 4: 1677-1687.
3. Boyle WJ, Smeal T, Defize LH, Angel P, Woodgett JR, Karin M et al. (1991). Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64: 573-584.
4. Chen BK, Huang CC, Chang WC, Chen YJ, Kikkawa U, Nakahama KI et al. (2007). PP2B-mediated dephosphorylation of c-Jun C-terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cells. Mol Biol Cell 18: 1118-1127.
5. Doble BW, Woodgett JR. (2003). GSK-3: tricks of the trade for a multi-tasking kinase. J Cell Sci 116: 1175-1186.
6. Eferl R, Wagner EF. (2003). AP-1: A double-edged sword in tumorigenesis. Nat Rev Cancer 3: 859-868.
7. Goto S, Matsukado Y, Mihara Y, Inoue N, Miyamoto E. (1987). An immunocytochemical demonstration of calcineurin in human nerve cell tumors. A comparison with neuron-specific enolase and glial fibrillary acidic protein. Cancer 60: 2948-2957.
8. Hou Q, Yi X, Jiang G, Wei Q. (2004). The salt bridge of calcineurin is important for transferring the effect of CNB binding to CAN. FEBS Lett 577: 294-298.
9. Jochum W, Passegue E, Wagner EF. (2001). AP-1 in mouse development and tumorigenesis. Oncogene 20: 2401-2412.
10. Kahl CR, Means AR. (2003). Regulation of cell cycle progression by calcium/calmodulin-dependent pathways. Endocr Rev 24: 719-736.
11. Karin M. (1995). The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 270: 16483-16486.
12. Klee CB, Draetta GF, Hubbard MJ. (1988). Calcineurin. Adv Enzymol Relat Areas Mol Biol 61: 149-200.
13. Lakshmikuttyamma A, Selvakumar P, Kanthan R, Kanthan SC, Sharma RK. (2005). Increased expression of calcineurin in human colorectal adenocarcinomas. J Cell Biochem 95: 731-739.
14. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U et al. (1992). Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 70: 777-789.
15. Miyawaki A, Llopis J, Heim R, McCaffery JM, Adams JA, Ikura M et al. (1997). Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin. Nature 388: 882-887.
16. Nomura T, Yamamoto H, Mimata H, Shitashige M, Shibasaki F, Miyamoto E et al. (2002). Enhancement by cyclosporin A of taxol-induced apoptosis of human urinary bladder cancer cells. Urol Res 30: 102-111.
17. Rusnak F, Mertz P. (2000). Calcineurin: form and function. Physiol Rev 80: 1483-1521.
18. Schutte J, Minna JD, Birrer MJ. (1989). Deregulated expression of human c-Jun transforms primary rat embryo cells in cooperation with an activated c-Ha-ras gene and transforms rat-1a cells as a single gene. Proc Natl Acad Sci USA 86: 2257-2261.
19. Shaulian E, Karin M. (2002). AP-1 as a regulator of cell life and death. Nat Cell Biol 4: E131-E136.
20. Smeal T, Binetruy B, Mercola DA, Birrer M, Karin M. (1991). Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354: 494-496.
21. Wei W, Jin J, Schlisio S, Harper JW, Kaelin Jr WG. (2005). The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 8: 25-33.
22. Wong WY, Havarstein LS, Morgan IM, Vogt PK. (1992). c-Jun causes focus formation and anchorage-independent growth in culture but is non-tumorigenic. Oncogene 7: 2077-2080.