Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis

Journal of Biomolecular Screening

Volumn 16, Issue 4, 2011, Pages 405-414

  Murakami, Gaku ^a   Inoue, Haruhisa ^b,c   Tsukita, Kayoko ^b,c   Asai, Yasuyuki ^d   Amagai, Yuji ^e   Aiba, Kazuhiro ^e   Shimogawa, Hiroki ^a   Uesugi, Motonari ^a   Nakatsuji, Norio ^f   Takahashi, Ryosuke ^a,c  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d ReproCELL Inc   (Japan)

^e Stem Cell and Drug Discovery Institute   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

amyotrophic lateral sclerosis; cell based assay; high throughput screening; superoxide dismutase 1

Indexed keywords

AGENTS ACTING ON THE PERIPHERAL NERVOUS AND NEUROMUSCULAR SYSTEMS; BETA ACTIN; COPPER ZINC SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ASTROCYTE; CONCENTRATION RESPONSE; CYTOTOXICITY; DOWN REGULATION; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

AMYOTROPHIC LATERAL SCLEROSIS; CELL LINE; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PROMOTER REGIONS, GENETIC; SMALL MOLECULE LIBRARIES; SUPEROXIDE DISMUTASE;

EID: 79955426954     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110397888     Document Type: Article

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