50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis

Amyotrophic Lateral Sclerosis

Volumn 9, Issue 4, 2008, Pages 229-237

  Broom, Wendy J ^a   Greenway, Matthew ^b,c   Sadri Vakili, Ghazaleh ^a   Russ, Carsten ^a   Auwarter, Kristen E ^a   Glajch, Kelly E ^a   Dupre, Nicolas ^d,e,f   Swingler, Robert ^g   Purcell, Shaun ^a   Hayward, Caroline ^h   Sapp, Peter ^a,i   McKenna Yasek, Diane ^a   Valdmanis, Paul ^d   Bouchard, Jean Pierre ^f   Meininger, Vincent ^j   Hosler, Betsy A ^a   Glass, Jonathan ^k   Polack, Meraida ^k   Rouleau, Guy ^d   Cha, Jang Ho ^a   Hardiman, Orla ^b,l   Brown Jr , Robert ^a   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^d NOTRE DAME HOSPITAL   (Canada)

^e UNIVERSITY OF MONTREAL   (Canada)

^f LAVAL UNIVERSITY   (Canada)

^g UNIVERSITY OF DUNDEE   (United Kingdom)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

ⁱ MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^j Centre National de Référence pour la Sclérose Latérale Amyotrophique   (France)

^k EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^l BEAUMONT HOSPITAL   (Ireland)

more..

Author keywords

Amyotrophic lateral sclerosis; Gene expression; Genetic; Heredity; Nucleic acid; Polymorphism; Regulatory sequences

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GENOMIC DNA; TRANSCRIPTION FACTOR SP1;

ADOLESCENT; ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CANADA; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE DELETION; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; IRELAND; MAJOR CLINICAL STUDY; MALE; NONHUMAN; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; REGULATORY SEQUENCE; UNITED KINGDOM; UNITED STATES;

AGE OF ONSET; AMYOTROPHIC LATERAL SCLEROSIS; BASE SEQUENCE; DNA MUTATIONAL ANALYSIS; FEMALE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HOMOZYGOTE; HUMANS; IRELAND; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); QUEBEC; RISK FACTORS; SCOTLAND; SEQUENCE DELETION; SP1 TRANSCRIPTION FACTOR; SUPEROXIDE DISMUTASE; UNITED STATES;

EID: 48249099724     PISSN: 17482968     EISSN: 1471180X     Source Type: Journal    
DOI: 10.1080/17482960802103107     Document Type: Article

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