Transgenic small interfering RNA halts amyotrophic lateral sclerosis in a mouse model

Journal of Biological Chemistry

Volumn 280, Issue 52, 2005, Pages 42826-42830

  Saito, Yuki ^a   Yokota, Takanori ^a   Mitani, Tasuku ^b   Ito, Kaoru ^a   Anzai, Masayuki ^b   Miyagishi, Makoto ^c   Taira, Kazunari ^c   Mizusawa, Hidehiro ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b KINKI UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; PROTEINS;

AMYOTROPHIC LATERAL SCLEROSIS (ALS); MUTATED GENES; SOD1 MUTATION;

RNA;

COPPER ZINC SUPEROXIDE DISMUTASE; SMALL INTERFERING RNA;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CONTROLLED STUDY; GENE MUTATION; GENE SILENCING; IN VIVO STUDY; MISSENSE MUTATION; MOUSE; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION; TRANSGENE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BASE SEQUENCE; BLOTTING, NORTHERN; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; GENE SILENCING; GENETIC VECTORS; GENOME; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; MUTATION, MISSENSE; PHENOTYPE; PLASMIDS; POINT MUTATION; RNA, SMALL INTERFERING; SPINAL CORD; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANSGENES;

ANIMALIA; MUS MUSCULUS;

EID: 29244434389     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M507685200     Document Type: Article

References (16)

1. Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., Rahmani, Z., Krizus, A., McKenna-Yasek, D., Cayabyab, A., Gaston, S. M., Berger, R., Tanzi, R. E., Halperin, J. J., Herzfeldt, B., Van den Bergh, R., Hung, W.-Y., Bird, T., Deng, G., Mulder, D. W., Smyth, C., Laing, N. G., Soriano, E., Pericak-Vance, M. A., Haines, J., Rouleau, G. A., Gusella, J. S., Horvitz, H. R., and Brown, R. H., Jr. (1993) Nature 362, 59-62
2. Cleveland, D. W. (1999) Neuron 24, 515-520
3. Yokota, T., Miyagishi, M., Hino, T., Matsumura, R., Andrea, T., Urushitani, M., Rao, R. V., Takahashi, R., Bredesen, D. E., Taira, K., and Mizusawa, H. (2004) Biochem. Biophys. Res. Com. 314, 283-291
4. Xia, H., Mao, Q., Eliason, S. L., Harper, S. Q., Martins, I. H., Orr, H. T., Paulson, H. L., Yang, L., Kotin, R. M., and Davidson, B. L. (2004) Nat. Med. 10, 816-820
5. Raoul, C., Abbas-Terki, T., Bensadoun, J.-C., Guillot, S., Haase, G., Szulc, J., Henderson, C. E., and Aebischer, P. (2005) Nat. Med. 11, 423-428
6. Ralph, G. S., Radcliffe, P. A., Day, D. M., Carthy, J. M., Leroux, M. A., Lee, D. C. P., Wong, L.-F., Bilsland, L. G., Greensmith, L., Kingsman, S. M., Mitrophanous, K. A., Mazarakis, N. D., and Azzouz, M. (2005) Nat. Med. 11, 429-433
7. Miller, T. M., Kasper, B. K., Kops, G. J., Yamanaka, K., Christian, L. J., Gage, F. H., and Cleveland, D. W. (2005) Ann. Neurol. 57, 773-776
8. Miyagishi, M., Sumimoto, H., Miyoshi, H., Kawakami, Y., and Taira, K. (2004) J. Gene Med. 6, 715-723
9. Hasuwa, H., and Okabe, M. (2003) Gene Medicine (Tokyo) 7, 59-64
10. Bruijn, L. I., Houseweart, M. K., Kato, S., Anderson, K. L., Anderson, S. D., Ohama, E., Reaume, A. G., Scott, R. W., and Cleveland, D. W. (1998) Science 281, 1851-1854
11. Matzuk, M. M., Dionne, L., Guo, Q., Kumar, T. R., and Lebovitz, R. M. (1998) Endocrinology 139, 4008-4011
12. Alexander, G. M., Erwin, K. L., Byers, N., Deitch, J. S., Augelli, B. J., Blankenhorn, E. P., and Heiman-Patterson, T. D. (2004) Mol. Brain Res. 130, 7-15
13. Gong, Y. H., Parsadanian, A. S., Andreeva, A., Snider, W. D., and Elliott, J. L. (2000) J. Neurosci. 20, 660-665
14. Lino, M. M., Schneider, C., and Caroni, P. (2002) J. Neurosci. 22, 4825-4832
15. Raoul, C., Estevez, A., Nishimune, H., Cleveland, D. W., deLapeyriere, O., Henderson, C. E., Haase, G., and Pettmann, B. (2002) Neuron 35, 1067-1083
16. Clement, A. M., Nguyen, M. D., Roberts, E. A., Garcia, M. L., Boillee, S., Rule, M., McMahon, A. P., Doucette, W., Siwek, D., Ferrante, R. J., Brown, R. H., Jr., Julien, J. P., Goldstein, L. S., and Cleveland, D. W. (2003) Science 302, 113-117