Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449)

Journal of Medicinal Chemistry

Volumn 54, Issue 8, 2011, Pages 2592-2601

  Giannetti, Anthony M ^a   Wong, Harvey ^a   Dijkgraaf, Gerrit J P ^a   Dueber, Erin C ^a   Ortwine, Daniel F ^a   Bravo, Brandon J ^a   Gould, Stephen E ^a   Plise, Emile G ^a   Lum, Bert L ^a   Malhi, Vikram ^a   Graham, Richard A ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CHLORO N [4 CHLORO 3 (2 PYRIDINYL)PHENYL] 4 METHANESULFONYLBENZAMIDE; HUMAN ALBUMIN; OROSOMUCOID; SONIC HEDGEHOG PROTEIN;

ANALYTIC METHOD; ARTICLE; BINDING AFFINITY; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG SELECTIVITY; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR DOCKING; NONHUMAN; PHASE 1 CLINICAL TRIAL (TOPIC); PLASMA PROTEIN BINDING; RAT; SURFACE PLASMON RESONANCE;

ANILIDES; ANIMALS; BIOPHYSICS; CELL LINE; HALF-LIFE; HEDGEHOG PROTEINS; HUMANS; PROTEIN BINDING; PYRIDINES; RATS; SIGNAL TRANSDUCTION; SPECIES SPECIFICITY; THERMODYNAMICS;

EID: 79955404921     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1008924     Document Type: Article

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