Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 9-10, 2010, Pages 785-790

  Ding, X ^a   Chou, B ^a   Graham, R A ^a   Cheeti, S ^a   Percey, S ^a   Matassa, L C ^b   Reuschel, S A ^b   Meng, M ^b   Liu, S ^b   Voelker, T ^b   Lum, B L ^a   Rudewicz, P J ^a   Hop, C E C A ^a  

^a GENENTECH INC   (United States)

^b Northwest Toxicology Inc   (United States)

Author keywords

96 Well SPE; GDC 0449; Hedgehog pathway inhibitor; HPI; Human plasma; LC MS MS

Indexed keywords

96-WELL; CALIBRATION CURVES; CLINICAL DEVELOPMENT; EXTRACTION RECOVERY; HEDGEHOG SIGNALING PATHWAYS; HUMAN PLASMAS; ION SUPPRESSION; IONSPRAY; LC-MS/MS; MATRIX; PATHWAY INHIBITORS; PHARMACOKINETIC PARAMETERS; PLASMA CONCENTRATION; QUADRATIC REGRESSION; QUANTITATIVE MATRICES; RECONSTITUTED SAMPLE; RELATIVE STANDARD DEVIATIONS; REVERSE PHASE CHROMATOGRAPHY; ROOM TEMPERATURE; SMALL-MOLECULE INHIBITORS; SOLID-PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME PERIODS;

CHROMATOGRAPHIC ANALYSIS; CUSTOMER SATISFACTION; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; PHASE INTERFACES; PLASMA (HUMAN); PLASMAS; SOLAR RADIATION; TOTAL QUALITY MANAGEMENT;

SOLVENT EXTRACTION;

ANTINEOPLASTIC AGENT; GDC 0449; PROTEIN INHIBITOR; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STABILITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; QUALITY CONTROL; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ANILIDES; CHROMATOGRAPHY, LIQUID; HEDGEHOG PROTEINS; HUMANS; PYRIDINES; SIGNAL TRANSDUCTION; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

ERINACEIDAE;

EID: 77649192027     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.01.039     Document Type: Article

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