The 1.8-Å Crystal Structure of α1-Acid Glycoprotein (Orosomucoid) Solved by UV RIP Reveals the Broad Drug-Binding Activity of This Human Plasma Lipocalin

Journal of Molecular Biology

Volumn 384, Issue 2, 2008, Pages 393-405

  Schönfeld, Dorian L ^a   Ravelli, Raimond B G ^b   Mueller, Uwe ^c   Skerra, Arne ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^c HAHN MEITNER INSTITUT   (Germany)

Author keywords

acute phase protein; ligand binding; protein engineering; UV radiation damage induced phasing; X ray crystallography

Indexed keywords

LIPOCALIN; OROSOMUCOID; DIAZEPAM; HISTIDINE; LIGAND; PROGESTERONE;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING; GLYCOSYLATION; HUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN INTERACTION; ULTRAVIOLET RADIATION; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; BLOOD; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; METHODOLOGY; MOLECULAR BIOLOGY; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY; SURFACE PROPERTY;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIAZEPAM; HISTIDINE; HUMANS; LIGANDS; LIPOCALINS; MODELS, MOLECULAR; MOLECULAR BIOLOGY; MOLECULAR SEQUENCE DATA; OROSOMUCOID; PROGESTERONE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; STRUCTURAL HOMOLOGY, PROTEIN; SURFACE PROPERTIES; ULTRAVIOLET RAYS;

EID: 54949158207     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.09.020     Document Type: Article

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