Bacterial conversion of folinic acid is required for antifolate resistance

Journal of Biological Chemistry

Volumn 286, Issue 17, 2011, Pages 15377-15390

  Ogwang, Sam ^a   Nguyen, Hoa T ^a   Sherman, Marissa ^a   Bajaksouzian, Saralee ^a   Jacobs, Michael R ^a   Boom, W Henry ^a   Zhang, Guo Fang ^a   Nguyen, Liem ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-MICROBIAL AGENT; ANTIFOLATES; BACTERIAL PATHOGENS; BIOCHEMICAL STUDIES; CLINICAL RESISTANCE; COMPLEMENTATION; FOLINIC ACID; GENETIC COMPLEMENTATION; HOMEOSTATIC CONTROL; METABOLIC FUNCTION; MYCOBACTERIUM SMEGMATIS; SYNTHASES;

BACTERIOLOGY; ENZYMES; ESCHERICHIA COLI; FUELS; GROWTH KINETICS; MICROORGANISMS;

ACID RESISTANCE;

DRUG METABOLIZING ENZYME; FOLATE UTILIZATION ENZYME FOR LEUCOVORIN; FOLIC ACID ANTAGONIST; FOLINIC ACID; FORMATE TETRAHYDROFOLATE LIGASE; METHYLENETETRAHYDROFOLIC ACID; SULFACHLORPYRIDAZINE; SULFADIAZINE; SULFADIMETHOXINE; SULFAMETHIZOLE; SULFAMETHOXAZOLE; SULFAMETHOXYPYRIDAZINE; SULFATHIAZOLE; SULFONAMIDE; TRIMETHOPRIM; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; DRUG METABOLISM; ENZYME ACTIVITY; ESCHERICHIA COLI; GENETIC COMPLEMENTATION; MINIMUM INHIBITORY CONCENTRATION; MUTAGENESIS; MYCOBACTERIUM SMEGMATIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANTI-BACTERIAL AGENTS; BACTERIA; BIOTRANSFORMATION; CARBON-NITROGEN LIGASES; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; HOMEOSTASIS; HUMANS; LEUCOVORIN; MUTATION; MYCOBACTERIUM SMEGMATIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MYCOBACTERIUM SMEGMATIS;

EID: 79955380871     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.231076     Document Type: Article

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