Biochemical and molecular studies of human methenyltetrahydrofolate synthetase

Oncologist

Volumn 1, Issue 4, 1996, Pages 248-254

  Jolivet, Jacques ^a   Dayan, Alain ^a   Beauchemin, Myriam ^a   Chahla, Dounia ^a   Mamo, Aline ^a   Bertrand, Richard ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

5 fluorouracil; Folate metabolism; Leucovorin

Indexed keywords

EID: 2642522930     PISSN: 10837159     EISSN: None     Source Type: Journal    
DOI: 10.1634/theoncologist.1-4-248     Document Type: Article

References (11)

1. Grem JL, Hoth DF, Hamilton JM et al. Overview of current status and future direction of clinical trials with 5-fluorouracil in combination with folinic acid. Cancer Treat Rep 1987;71:1249-1264.
2. Jolivet J, Cowan KH, Curt GA et al. The pharmacology and clinical use of methotrexate. N Engl J Med 1983;309:1094-1104.
3. Stover P, Schirch V. The metabolic role of leucovorin. Trends Biochem Sci 1993;18:102-106.
4. Kisliuk RL. In: Folate antagonists as therapeutic agents, Sirontnak FM, Burchall JJ, Ensminger WB et al., eds. Orlando: Academic Press 1984:2-68.
5. Shane B. Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism. Vitam Horm 1989;45:263-335.
6. MacKenzie RE. In: Folates and pterins. Blakely RL, Benkovic SJ, eds. New York: John Wiley and Sons 1984;1:255-306.
7. Appling DR. Compartmentation of folate-mediated one-carbon metabolism in eukaryotes. FASEB J 1991;5:2645-2651.
8. Priest DG, Schmitz JC, Bunni MA et al. Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously. J Natl Cancer Inst 1991;83:1806-1812.
9. Chasin LA, Feldman A, Konstam M et al. Reversion of a Chinese hamster cell auxotrophic mutant. Proc Natl Acad Sci USA 1974;71:718-722.
10. Heidelberger C, Danenberg PV, Moran RG. In: Meister A, ed. Advances in Enzymology and Related Areas in Molecular Biology. New York: John Wiley and Sons, 1983:57-119.
11. Lockshin A, Danenberg PV. Biochemical factors affecting the tightness of 5-fluorodeoxyuridylate binding to human thymidylate synthetase. Biochem Pharmacol 1981;30:247-251.