Lowering glycosphingolipid levels in CD4+ T cells attenuates T cell receptor signaling, cytokine production, and differentiation to the Th 17 lineage

Journal of Biological Chemistry

Volumn 286, Issue 17, 2011, Pages 14787-14794

  Zhu, Yunxiang ^a   Gumlaw, Nathan ^a   Karman, Jozsef ^a   Zhao, Hongmei ^a   Zhang, Jinhua ^a   Jiang, Ji Lei ^a   Maniatis, Pete ^a   Edling, Andrea ^a   Chuang, Wei Lien ^a   Siegel, Craig ^a   Shayman, James A ^b   Kaplan, Johanne ^a   Jiang, Canwen ^a   Cheng, Seng H ^a  

^a GENZYME CORPORATION   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE PRODUCTION; GLUCOSYLCERAMIDE SYNTHASE; GLYCOSPHINGOLIPIDS; IMMUNOLOGICAL SYNAPSE; IN-VITRO; LIPID RAFT; PHARMACOLOGICAL INHIBITION; POTENT INHIBITOR; SIGNALING ACTIVITY; SIGNALING EVENTS; SIGNALING MOLECULES; SYNTHASES; T CELL ACTIVATION; T CELL PROLIFERATION; T CELL RECEPTOR; T CELLS; T-CELL RECEPTORS; T-CELL RESPONSE; TRANSGENIC MICE;

CELL MEMBRANES; CELL PROLIFERATION; FLOCCULATION; GENES; PHOSPHORYLATION; PLANTS (BOTANY);

SIGNALING;

CALCIUM ION; CD4 ANTIGEN; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; CYTOKINE; GANGLIOSIDE GM3; GLYCOSPHINGOLIPID; INTERLEUKIN 2; LAT PROTEIN; PROTEIN KINASE LCK; PROTEIN KINASE ZAP 70; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CALCIUM MOBILIZATION; CD4+ T LYMPHOCYTE; CELL ISOLATION; CELL LINEAGE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID RAFT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH17 CELL; TRANSGENIC MOUSE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINEAGE; CYTOKINES; GLYCOSPHINGOLIPIDS; IMMUNOLOGICAL SYNAPSES; MEMBRANE MICRODOMAINS; MICE; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TH17 CELLS;

MUS MUSCULUS;

EID: 79955367527     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.218610     Document Type: Article

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