Role of GM3-enriched microdomains in signal transduction regulation in T lymphocytes

Glycoconjugate Journal

Volumn 20, Issue 1, 2003, Pages 63-70

  Sorice, Maurizio ^a   Longo, Agostina ^a   Garofalo, Tina ^a   Mattei, Vincenzo ^a   Misasi, Roberta ^a   Pavan, Antonio ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Gangliosides; GM3; Microdomains; Rafts; T lymphocytes

Indexed keywords

BIOCHEMICAL MARKER; GANGLIOSIDE GM3; GLYCOSPHINGOLIPID; GLYCOSYLPHOSPHATIDYLINOSITOL; GUANINE NUCLEOTIDE BINDING PROTEIN; ISOENZYME; PROTEIN KINASE C; PROTEIN KINASE FYN; PROTEIN KINASE LCK; PROTEIN KINASE LYN; PROTEIN TYROSINE KINASE; RAP PROTEIN; RAS PROTEIN; SIALIC ACID; TYROSINE KINASE RECEPTOR;

APOPTOSIS; CELL ACTIVATION; CELL INTERACTION; CELL MEMBRANE; CONFERENCE PAPER; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

EID: 1642268642     PISSN: 02820080     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:GLYC.0000018018.29488.c6     Document Type: Conference Paper

References (78)

1. Hannun YA, Bell RM, Functions of sphingolipids and sphingolipid breakdown products in cellular regulation, Science 243, 500-7 (1989).
2. Fishman PH, Role of membrane gangliosides in the binding and actions of bacterial toxins, J Membr Biol 69, 85-97 (1982).
3. Whisler RL, Yates AJ, Regulation of lymphocytes responses by human gangliosides: Characteristics of inhibitory effects and the induction of impaired activation, J Immunol 125, 2106-11 (1980).
4. Usuki S, Hoops P, Sweely CC, Growth control of human foreskin fibroblasts and inhibition of extracellular sialidase activity by 2-Deoxy-2,3 dehydro-N-Acetyl neuraminic acid, J Biol Chem 263, 10595-9 (1988).
5. Bremer EG, Schlessinger J, Hakomori S, Ganglioside-mediated modulation of cell growth: Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor, J Biol Chem 261, 2434-40 (1986).
6. Hakomori S, Glycosphingolipids in cellular interactions differentiation and oncogenesis, Annu Rev Biochem 50, 733-64 (1981).
7. Kiguchi K, Henning-Chubb BC, Huberman E, Glycosphingolipid patterns peripheral blood lymphocytes-monocytes, and granulocytes are cell specific, J Biochem 107, 8-14 (1990).
8. Sorice M, Parolini I, Sansolini T, Garofalo T, Dolo V, Sargiacomo M, Tai T, Peschle C, Torrisi MR, Pavan A, Evidence for the existence of ganglioside-enriched plasma membrane domains in human peripheral lymphocytes, J Lipid Res 38, 969-80 (1997).
9. Garofalo T, Lenti L, Longo A, Misasi R, Mattei V, Pontieri GM, Pavan A, Sorice M, Association of GM3 with Zap-70 induced by T cell activation in plasma membrane microdomains, J Biol Chem 227, 11233-8 (2002).
10. The members of the Nomenclature committee of the 4th International workshop on human leukocyte differentiation antigens. Workshop on Antigen designation, J Immunol 143, 758 (1989).
11. Wasik MA, Preferential interaction of the CD4+29+/45RA-subset of human CD4+ T lymphocytes with an antibody against the cell membrane ganglioside GD3, Scand J Immunol 35, 421-8 (1992).
12. Merrit WD, Taylor BJ, Der-Minassian V, Reaman GH, Co-expression of GD3 gangliosides with CD45RO in resting and activated human T lymphocytes, Cell Immunol 173, 131-48 (1996).
13. Ebel F, Schmitt E, Katalinic JP, Kniep B, Muhlradt F, Gangliosides: Differentiation markers for murine T helper lymphocyte subpopulation TH1 and TH2, Biochemistry 31, 12190-7 (1992).
14. Sorice M, Garofalo T, Sansolini T, Griggi T, Circella A, Massetti AP, Tai T, Pavan A, Overexpression of monosialoganglioside GM3 on lymphocyte plasmamembrane in patients with HIV infection, J Acq Immune Defic Syndr Human Retrov 12, 112-9 (1996).
15. Sharom FJ, Grant CWM, A model for ganglioside behaviour in cell membranes, Biochim Biophys Acta 507, 280-93 (1978).
16. Cametti C, De Luca F, D'Ilario A, Macrì MA, Maraviglia B, Bordi F, Lenti L, Misasi R, Sorice M, Alteration of the passive electrical properties of lymphocyte membranes induced by GM1 and GM3 glycolipids, Biochim Biophys Acta 1111, 197-203 (1992).
17. Offner H, Thieme T, Vanderbark AA, Gangliosides induce selective modulation of CD4 from helper T lymphocytes, J Immunol 139, 3295-305 (1987).
18. Sattentau QI, Weiss RA, The CD4 antigen: Physiological ligand and HIV receptor, Cell 52, 631-3 (1988).
19. Chieco-Bianchi L, Calabrò ML, Panozzo M, De Rossi A, Amadori A, Callegaro L, Siccardi A, CD4 modulation and inhibition of HIV-infectivity induced by monosialoganglioside GM1 in vitro, AIDS 3, 501-7 (1989).
20. Grassi F, Lopalco L, Lanza T, Ciccomascolo F, Cazzola F, Di Martino A, Kirschmner G, Callegaro L, Chieco Bianchi L, Siccardi AG, Chemical residues of ganglioside molecules involved in interactions with lymphocyte surface target leading to CD4 masking and inhibition of mitogenic proliferation, Eur J Immunol 20, 145-50 (1990).
21. Kawaguchi T, Nakakuma H, Kagimoto T, Shirono K, Horikawa K, Hidaka M, Iwamori M, Nagai Y, Takatsuki K, Characteristic mode of action of gangliosides in selective modulation of CD4 on human T lymphocytes, Biochem Biophys Res Commun 158, 1050-9 (1989).
22. Morrison WJ, Offner H, Vandenbark AA, Ganglioside(GM1)-treated T cells shed CD4, Immunopharmacology 22, 77-84 (1991).
23. Sorice M, Pavan A, Misasi R, Sansolini T, Garofalo T, Lenti L, Pontieri GM, Frati L, Torrisi MT, Monosialogangliosides GM3 induces CD4 internalization in human peripheral blood T lymphocytes, Scand J Immunol 41, 148-56 (1995).
24. Shin J, Dunbrack RL, Lee Jr S, Strominger JL, Phosphorylation-dependent downmodulation of CD4 requires aspecific structure within the cytoplasmatic domain of CD4, J Biol Chem 266, 10658-65 (1991).
25. Garofalo T, Sorice M, Misasi R, Cinque B, Giammatteo M, Pontieri GM, Cifone G, Pavan A, A novel mechanism of CD4 down-modulation induced by monosialoganglioside GM3. Involvement of serine phosphorylation and protein kinase C delta translocation, J Biol Chem 273, 35153-60 (1998).
26. Marsh M, Pelchen-Matthews A, Endocytic and exocytic regulation of CD4 expression and function, Curr Top Microbiol Immunol 205, 107-37 (1996).
27. Krifuks O, Bergelson LD, Schlesinger M, The down-modulation of CD4 induced by the GM1 gangliosides is regulated by phosphatases and kinases: Evidence from enzyme inhibitors and anti-CD45 antibodies, Cell Immunol 187, 45-51 (1998).
28. Basu S, Basu M, Dastgheib S, Hawes JW, Biosynthesis and regulation of glycosphingolipids. In Comprehensive Natural Products Chemistry, edited by Barton D, Nakanishi K, Meth-Cohen O, vol. 3, Pinto BM (ed.). (Pergamon Press, New York) pp. 107-28.
29. Nishizuka Y, Protein kinase C and lipid signaling for sustained cellular resposes, FASEB J 9, 484-96 (1995).
30. Lin LL, Wartmann M, Lin AY, Knopf JL, Seth A, Davis R, cPLA-2 is phosphorylated and activated by MAP kinase, Cell 72, 269-78 (1993).
31. Nemenoff RA, Winitz S, Qian NX, Van Putten V, Johnson GL, Heasley LE, Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2-kinase and protein kinase C, J Biol Chem 268, 1960-4 (1993).
32. Seger R, Krebs EG, The MAPK signaling cascade, FASEB J 9, 726-35 (1995).
33. Garofalo T, Sorice M, Misasi R, Cinque B, Mattei V, Pontieri GM, Cifone MG, Pavan A, Ganglioside GM3 activates ERKs in human lymphocytic cells, J Lipid Res 43, 971-8 (2002).
34. Exton JH, Phosphatidylcholine breakdown and signal tranduction, Biochim Biophys Acta 1212, 26-42 (1994).
35. Ha KS, Exton JH, Differential translocation of protein kinase C isozymes by trombin and platelet-derivaved growth factor. A possible function for phosphatidylcholine derived diacylglycerol, J Biol Chem 258, 10534-9 (1993).
36. Masserini M, Palestini P, Pitto M, Glycolipid-enriched caveolae and caveolae-like domains in the nervous system, J Neurochem 73, 1-11 (1999).
37. Hakomori S, Handa K, Iwabuchi K, Yamamura S, Prinetti A, New insights in glycosphingolipid function "glycosignaling domain", a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling, Glycobiology 8, XI-XVIII (1998).
38. Singer SJ, Nicholson GL, The fluid mosaic model of the structure of cell membranes, Science 75, 720-31 (1972).
39. Parton RG, Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae, J Histochem Cytochem 42, 155-66 (1994).
40. Galandrini R, Tassi I, Mattia G, Lenti L, Piccoli M, Frati L, Santoni A, SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells, Blood 100, 4581-9 (2002).
41. Xavier R, Brennan T, Li Q, McCormack C, Seed B, Membrane compartmentation is required for efficient T cell activation, Immunity 8, 723-32 (1998).
42. Chun M, Liyanage UK, Lisanti MP, Lodish HF, Signal transduction of a G-protein coupled receptor in caveolae: Colocalization of endothelin and its receptor with caveolin, Proc Natl Acad Sci USA 91, 11728-32 (1994).
43. Rodgers V, Rose JK, Exclusion of CD45 inhibits activity of p56 lck associated with glycolipid enriched membrane domains, J Cell Biol 135, 1515-23 (1996).
44. Parolini I, Sargiacomo M, Lisanti MP, Peschle C, Signal transduction and glycophosphatidylinositol-linked proteins (lyn, lck, CD4, CD45, G-proteins, and CD55) selectively localize in Triton-insoluble plasma membrane domains of human leukemic cell lines and normal granulocytes, Blood 87, 3783-94 (1996).
45. Parolini I, Topa S, Sorice M, Pace A, Geddia P, Montesoro E, Pavan A, Lisanti MP, Peschle C, Sargiacomo M, Phorbol ester-induced disruption of the CD4-lck complex occur within a detergent-resistant microdomain of the plasma membrane. Involvement of the translocation of activated protein kinase C isoform, J Biol Chem 274, 14176-87 (1999).
46. Cinek T, Horejsi VJ, The nature of large non covalent complexes containing glycosyl-phosphatidylnositol-anchored membrane glycoproteins and protein tyrosine kinases, Immunology 149, 2262-70 (1992).
47. Horejsi V, Drbal K, Cebecauer M, Cerny J, Brdicka T, Angelisova P, Stockinger H, GPI-microdomains: A role in signaling via immunoreceptors, Immunology Today 20, 356-61 (1999).
48. Furley A, Morton JS, Manalo BD, Karagogeos D, Dodd J, Jessel T, The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member neurite outgrowth promoting activity, Cell 61, 157-70 (1990).
49. Pimenta AF, Zhukareva V, Barbe MF, Reinoso BS, Grimley C, Henzel W, Fisher I, Levitt P, The limbic system associated membrane protein is an Ig superfamily member that mediates selective neuronal growth and axon targeting, Neuron 15, 287-97 (1995).
50. Olive S, Dubois C, Schachner M, Rougon G, The F3 neuronal glycosylphosphatidyl inositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and Fyn kinase in cerebellum, J Neurochem 65, 2307-17 (1995).
51. Parkin ET, Hussain I, Turner AJ, Hopper NM, The amyloid precursor protein is not enriched in caveolae-like, detergent-insoluble membrane microdomains, J Neurochem 69, 2179-88 (1997).
52. Leitinger B, Hogg N, The involvement of lipid rafts in the regulation of integrin function, J Cell Science 115, 963-72 (2002).
53. Shamri R, Grabovsky V, Feigelson, Dwir O, Van Kooyk Y, Alon R, Chemokine stimulation of lymphocyte α4 integrin avidity but not of LFA-1 avidity to endothelial Ligands under shear flow requires cholesterol membrane rafts, J Biol Chem 227, 40027-35 (2002).
54. Simons K, Van Meer G, Lipid sorting in epithelial cells, Biochemistry 27, 6197-02 (1988).
55. Simons K, Ikonen E, Functional rafts in cell membranes, Nature 387, 569-72 (1997).
56. Fra AM, Williamson E, Simons K, Parton RG, Detergent-insoluble glycolipid microdomains in lymphocytes in the absence of caveolae, J Biol Chem 269, 30745-8 (1994).
57. Stefanova I, Horejsi V, Association of the CD59 and CD55 cell surface glycoproteins with other membrane molecules, J Immunol 147, 1587-92 (1991).
58. Mutoh T, Tokuda A, Miyadai T, Hamaguchi M, Fujiki N, Ganglioside GM1 binds to the Trk protein and regulates receptor function, Proc Natl Acad Sci USA 92, 5087-91 (1995).
59. Misasi R, Sorice M, Garofalo T, Griggi T, Campana WM, Giammatteo M, Pavan A, Hiraiwa M, Pontieri GM, O'Brien J, Colocalization and complex formation between prosaposin and monosialoganglioside GM3 in neuronal cells, J Neurochem 71, 2313-21 (1998).
60. Sorice M, Garofalo T, Misasi R, Longo A, Mikulak J, Dolo V, Pontieri GM, Pavan A, Association between GM3 and CD4-lck complex in human peripheral blood lymphocytes, Glycocon J 17, 247-52 (2000).
61. Sorice M, Garofalo T, Misasi R, Longo A, Mattel V, Sale P, Dolo V, Gradini R, Pavan A, Evidence for cell surface association between CXCR4 and ganglioside GM3 after gp120 binding in SupT1 lymphoblastoid cells, FEBS Letters 506, 55-60 (2001).
62. Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A, T lymphocytes costimulation mediated by reorganization of membrane microdomains, Science 283, 680-2 (1999).
63. Moran M, Miceli MC, Engagement of GPI-linked CD48 contributes to TCR signals and cytoskeletal reorganization: A role for lipid rafts in T cell activation, Immunity 9, 787-96 (1998).
64. Montixi C, Langlet C, Bernard AM, Thimonier J, Dubois C, Wurbel MA, Chauvin JP, Pierres M, He HT, Engagement of T cell receptor triggers its recruitment to low-density detergent-insoluble membrane domains, EMBO J 17, 5334-48 (1998).
65. Wu L, Yu Z, Shen SH, SKAP55 recruits to lipids rafts and positively mediates MAPK pathway upon TCR activation, J Biol Chem 277, 40420-7 (2002).
66. Goebel J, Forrest K, Morford L, Roszman TL, Differential localization of IL-2 and 15 receptor chains in membrane rafts of human T cells, J Leukocyte Biol 72, 199-206 (2002).
67. Zhang W, Trible RP, Samelson LE, LAT palmitoylation: Its essential role the membrane microdomain targeting and tyrosine phosphorylation during T cell activation, Immunity 9, 239-46 (1998).
68. Leyton L, Quest AFG, Bron C, Thy-1/CD3 coengagement promotes TCR signaling and enhances particularly tyrosine phosphorylation of the raft molecule LAT, Molec Immunol 36, 755-68 (1999).
69. Kasahara K, Watanabe Y, Yamamoto T, Sanai Y, Association of Src family tyrosine kinase lyn with ganglioside GD3 in rat brain, J Biol Chem 272, 29947-53 (1997).
70. Muzio M, Chinnaiyan FC, Kischkel K, O'Rourke K, Shevchenko A, Carsten-Scaffidi JN, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Dixit VM, FLICE, A novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex, Cell 85, 817-27 (1996).
71. Scaffidi C, Kirchhoff S, Krammer PH, Peter ME, Apoptosis signaling in lymphocytes, Curr Opin Immunol 11, 277-85 (1999).
72. Langlet C, Bernard AM, Drevot P, He HT, Membrane rafts and signaling by the multichain immune recognition receptors, Curr Opin Immunol 12, 250-5 (2000).
73. Ko YG, Lee JS, Kang YS, Ahn JH, Seo JS, NF-alpha-mediated apoptosis is initiated in caveolae-like domains, J Immunol 162, 7217-23 (1999).
74. Grassmé H, Jekle A, Riehle A, Schwarz H, Berger J, Sandhoff K, Kolesnick R, Gulbins E, CD95 signaling via ceramide-rich membrane rafts, J Biol Chem 276, 20589-96 (2001).
75. Hueber AO, Bernard AM, Herincs Z, Couzinet A, He HT, An essential role for membrane rafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes, EMBO Rep 3, 190-6 (2002).
76. Toellner DS, Wang K, Singh R, Majeed S, Raza K, Curnow SJ, Salmon M, Lord JM, The death-inducing signaling complex is recruited to lipid rafts in Fas-induced apoptosis, Biochem Biophys Res Commun 297, 876-9 (2002).
77. Giammarioli AM, Garofalo T, Sorice M, Misasi R, Gambardella L, Gradini R, Fais S, Pavan A, Malorni W, GD3 glycosphingolipid contributes to FAS-mediate apoptosis via association with ezrin cytoskeletal protein, FEBS Letters 506, 45-50 (2001).
78. Garofalo T, Misasi R, Mattei V, Giammarioli AM, Malorni W, Pontieri GM, Pavan A, Sorice M, Association of the Death-inducing Signaling Complex with Microdomains after Triggering through CD95/Fas. Evidence for caspase-8-ganglioside interaction in T cells, J Biol Chem 278, 8309-15 (2003).