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Volumn 16, Issue 1, 2011, Pages 116-130

Influence of polymorphisms on EGFR targeted therapy in non-small-cell lung cancer

Author keywords

EGFR; Non small cell lung cancer; Outcome; Polymorphisms; Review; Targeted therapies; Toxicity

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; GEFITINIB; MONOCLONAL ANTIBODY; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; QUINAZOLINE DERIVATIVE;

EID: 79955049817     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3679     Document Type: Article
Times cited : (9)

References (96)
  • 2
    • 21344448883 scopus 로고    scopus 로고
    • Medical treatment of non-small-cell lung cancer
    • DOI 10.1093/annonc/mdi721
    • Buter J, Giaccone G. Medical treatment of non-smallcell lung cancer. Ann Oncol 16 Suppl 2: ii229-ii232 (2005) (Pubitemid 40908962)
    • (2005) Annals of Oncology , vol.16 , Issue.SUPPL. 2
    • Buter, J.1    Giaccone, G.2
  • 3
    • 0028843552 scopus 로고
    • Chemotherapy in non-small cell lung cancer: A metaanalysis using updated data on individuals patients from 52 randomized clinical trials
    • Non-Small Cell Lung Cancer Collaborative Group
    • Non-Small Cell Lung Cancer Collaborative Group. Chemotherapy in non-small cell lung cancer: a metaanalysis using updated data on individuals patients from 52 randomized clinical trials. Br Med J 311, 899-909 (1995)
    • (1995) Br Med J , vol.311 , pp. 899-909
  • 4
    • 0013594517 scopus 로고    scopus 로고
    • New chemotherapeutic agents prolong survival and improve quality of life in non-small cell lung cancer: A review of the literature and future directions
    • Bunn PA Jr, Kelly K. New chemotherapeutic agents prolong survival and improve quality of life in non-small cell lung cancer: a review of the literature and future directions. Clin Cancer Res 4, 1087-100 (1998) (Pubitemid 28213318)
    • (1998) Clinical Cancer Research , vol.4 , Issue.5 , pp. 1087-1100
    • Bunn Jr., P.A.1    Kelly, K.2
  • 8
    • 68249141850 scopus 로고    scopus 로고
    • Using EGFR status to personalize treatment: Lung cancer researchers reach a milestone
    • Friedrich MJ. Using EGFR status to personalize treatment: lung cancer researchers reach a milestone. J Natl Cancer Inst 101, 1039-41 (2009)
    • (2009) J Natl Cancer Inst , vol.101 , pp. 1039-1041
    • Friedrich, M.J.1
  • 9
    • 70350490045 scopus 로고    scopus 로고
    • Gefitinib: A review of its use in the treatment of locally advanced/metastatic non-small cell lung cancer
    • Sanford M, Scott LJ. Gefitinib: a review of its use in the treatment of locally advanced/metastatic non-small cell lung cancer. Drugs 69, 2303-28 (2009)
    • (2009) Drugs , vol.69 , pp. 2303-2328
    • Sanford, M.1    Scott, L.J.2
  • 10
    • 33845398258 scopus 로고    scopus 로고
    • Response to erlotinib in first-line treatment of non-small-cell lung cancer in a white male smoker with squamous-cell histology
    • Achille M, Gallegos-Ruiz M, Giaccone G, Soria JC. Response to erlotinib in first-line treatment of non-smallcell lung cancer in a white male smoker with squamous-cell histology. Clin Lung Cancer 8, 214-216 (2006) (Pubitemid 44896395)
    • (2006) Clinical Lung Cancer , vol.8 , Issue.3 , pp. 214-216
    • Achille, M.1    Gallegos-Ruiz, M.2    Giaccone, G.3    Soria, J.-C.4
  • 13
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PloSMed 2:e73 (2005)
    • (2005) PloSMed , vol.2
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 18
    • 28444480186 scopus 로고    scopus 로고
    • Concordance of pharmacogenetic markers in germline and colorectal tumor DNA
    • DOI 10.2217/14622416.6.8.873
    • Marsh S, Mallon MA, Goodfellow P, McLeod HL. Concordance of pharmacogenetic markers in germline and colorectal tumour DNA. Pharmacogenomics 6, 873-877 (2005) (Pubitemid 41724361)
    • (2005) Pharmacogenomics , vol.6 , Issue.8 , pp. 873-877
    • Marsh, S.1    Mallon, M.A.2    Goodfellow, P.3    McLeod, H.L.4
  • 19
    • 85034842763 scopus 로고    scopus 로고
    • Cytoplasmic signaling circuitry programs many of the traits of cancer
    • Chapter 6. Eds: Garland Science
    • Weinberg RA. Cytoplasmic signaling circuitry programs many of the traits of cancer. In: The biology of cancer, Chapter 6. Eds: Garland Science (2006)
    • (2006) The Biology of Cancer
    • Weinberg, R.A.1
  • 23
    • 0035884231 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia
    • Arteaga CL. The epidermal growth factor receptor: From mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia. J Clin Oncol 19, 32s-40s (2001) (Pubitemid 32880077)
    • (2001) Journal of Clinical Oncology , vol.19 , Issue.18 SUPPL.
    • Arteaga, C.L.1
  • 24
    • 0036362181 scopus 로고    scopus 로고
    • Why the epidermal growth factor receptor? The rationale for cancer therapy
    • Baselga J. Why the epidermal growth factor receptor? The rationale for cancer therapy. Oncologist 7 (suppl 4), 2-8 (2002) (Pubitemid 34977157)
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 2-8
    • Baselga, J.1
  • 25
    • 3042665929 scopus 로고    scopus 로고
    • The biology of epidermal growth factor receptor in lung cancer
    • DOI 10.1158/1078-0432.CCR-040007
    • Scagliotti GV, Selvaggi G, Novello S, Hirsch FR. The biology of epidermal growth factor receptor in lung cancer. Clin Cancer Res 10, 4227s-4232s (2004) (Pubitemid 38812451)
    • (2004) Clinical Cancer Research , vol.10 , Issue.12
    • Scagliotti, G.V.1    Selvaggi, G.2    Novello, S.3    Hirsch, F.R.4
  • 26
    • 33749316418 scopus 로고    scopus 로고
    • The epidermal growth factor receptor pathway: A model for targeted therapy
    • DOI 10.1158/1078-0432.CCR-05-1554
    • Scaltriti M, Baselga J. The epidermal growth factor receptor pathway: a model for targeted therapy. Clin Cancer Res12, 5268-5272 (2006) (Pubitemid 44497237)
    • (2006) Clinical Cancer Research , vol.12 , Issue.18 , pp. 5268-5272
    • Scaltriti, M.1    Baselga, J.2
  • 27
    • 26444519872 scopus 로고    scopus 로고
    • Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and Gefitinib (Iressa)
    • DOI 10.1634/theoncologist.10-8-579
    • Siegel-Lakhai WS, Beijnen JH, Schellens JH. Current knowledge and future directions of the selective epidermal growth factor receptor inhibitors erlotinib (Tarceva) and gefitinib (Iressa). Oncologist 10, 579-589 (2005) (Pubitemid 41429121)
    • (2005) Oncologist , vol.10 , Issue.8 , pp. 579-589
    • Siegel-Lakhai, W.S.1    Beijnen, J.H.2    Schellens, J.H.M.3
  • 28
    • 32944469063 scopus 로고    scopus 로고
    • Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized, crossover study in healthy subjects
    • DOI 10.1177/0091270005284193
    • Frohna P, Lu J, Eppler S, Hamilton M, Wolf J, Rakhit A, Ling J, Kenkare-Mitra SR, Lum BL. Evaluation of the absolute oral bioavailability and bioequivalence of erlotinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in a randomized, crossover study in healthy subjects. J Clin. Pharmacol 46, 282-290 (2006) (Pubitemid 43260315)
    • (2006) Journal of Clinical Pharmacology , vol.46 , Issue.3 , pp. 282-290
    • Frohna, P.1    Lu, J.2    Eppler, S.3    Hamilton, M.4    Wolf, J.5    Rakhit, A.6    Ling, J.7    Kenkare-Mitra, S.R.8    Lum, B.L.9
  • 29
    • 33746678595 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non-small cell lung cancer
    • DOI 10.1016/j.clpt.2006.04.007, PII S0009923606001627
    • Lu JF, Eppler SM, Wolf J, Hamilton M, Rakhit A, Bruno R, Lum BL. Clinical pharmacokinetics of erlotinib in patients with solid tumors and exposure-safety relationship in patients with non-small cell lung cancer. Clin Pharmacol Ther 80, 136-145 (2006) (Pubitemid 44160689)
    • (2006) Clinical Pharmacology and Therapeutics , vol.80 , Issue.2 , pp. 136-145
    • Lu, J.-F.1    Eppler, S.M.2    Wolf, J.3    Hamilton, M.4    Rakhit, A.5    Bruno, R.6    Lum, B.L.7
  • 30
    • 34250694236 scopus 로고    scopus 로고
    • Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes
    • DOI 10.1158/1078-0432.CCR-07-0088
    • Li J, Zhao M, He P, Hidalgo M, Baker SD. Differential metabolism of gefitinib and erlotinib by human cytochrome P450 enzymes. Clin Cancer Res 13(12), 3731-3737 (2007) (Pubitemid 46955138)
    • (2007) Clinical Cancer Research , vol.13 , Issue.12 , pp. 3731-3737
    • Li, J.1    Zhao, M.2    He, P.3    Hidalgo, M.4    Baker, S.D.5
  • 31
    • 33646888233 scopus 로고    scopus 로고
    • Where next for gefitinib in patients with lung cancer?
    • DOI 10.1016/S1470-2045(06)70725-2, PII S1470204506707252
    • Blackhall F, Ranson M, Thatcher N. Where next for gefitinib in patients with lung cancer? Lancet Oncol 7, 499-507 (2006) (Pubitemid 43779172)
    • (2006) Lancet Oncology , vol.7 , Issue.6 , pp. 499-507
    • Blackhall, F.1    Ranson, M.2    Thatcher, N.3
  • 33
    • 0031868728 scopus 로고    scopus 로고
    • Anti-(epidermal growth factor) receptor monoclonal antibodies for the induction of antibody-dependent cell-mediated cytotoxicity against squamous cell carcinoma lines of the head and neck
    • DOI 10.1007/s002620050475
    • Bier H, Hoffman T, Haas I, van Lierop A. Anti-(epidermal growth factor) receptor monoclonal antibodies for the induction of antibody-dependent cell-mediated cytotoxicity against squamous cell carcinoma lines of the head and neck. Cancer Immunol Immunother 46, 167-173 (1998) (Pubitemid 28239882)
    • (1998) Cancer Immunology Immunotherapy , vol.46 , Issue.3 , pp. 167-173
    • Bier, H.1    Hoffmann, T.2    Haas, I.3    Van Lierop, A.4
  • 34
    • 51349109631 scopus 로고    scopus 로고
    • Randomized, multicenter, Phase III study of cetuximab in combination with cisplatin/vinorelbine (CV) versus CV alone in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC)
    • abstr 3
    • Pirker R, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, Park K, Gatzemeier U, Bajeta E, Emig M, Pereira JR. FLEX: A randomized, multicenter, Phase III study of cetuximab in combination with cisplatin/vinorelbine (CV) versus CV alone in the first-line treatment of patients with advanced non-small cell lung cancer (NSCLC). J Clin. Oncol 26, 20 Suppl, abstr 3 (2008)
    • (2008) J Clin. Oncol , vol.26 , Issue.20 SUPPL.
    • Pirker, R.1    Szczesna, A.2    Von Pawel, J.3    Krzakowski, M.4    Ramlau, R.5    Park, K.6    Gatzemeier, U.7    Bajeta, E.8    Emig, M.9    Pereira, J.R.10    Flex, A.11
  • 37
    • 55549127901 scopus 로고    scopus 로고
    • Cetuximab in combination with carboplatin and docetaxel for patients with metastatic or advanced-stage nonsmall cell lung cancer: Amulticenter phase 2 study
    • Belani CP, Schreeder MT, Steis RG, Guidice RA, Marsland TA, Butler EH, Ramalingam SS. Cetuximab in combination with carboplatin and docetaxel for patients with metastatic or advanced-stage nonsmall cell lung cancer: amulticenter phase 2 study. Cancer 113, 2512-2517 (2008)
    • (2008) Cancer , vol.113 , pp. 2512-2517
    • Belani, C.P.1    Schreeder, M.T.2    Steis, R.G.3    Guidice, R.A.4    Marsland, T.A.5    Butler, E.H.6    Ramalingam, S.S.7
  • 38
    • 0035425225 scopus 로고    scopus 로고
    • Pharmacogenetic determinants of anti-cancer drug activity and toxicity
    • DOI 10.1016/S0165-6147(00)01742-9, PII S0165614700017429
    • Romano D, De Braud F, Fogli S, Di Paolo A, Del Tacca M. Pharmacogenetic determinants of anti-cancer drug activity and toxicity. Trends Pharmacol Sci 22 (8), 420-426 (2001) (Pubitemid 32718634)
    • (2001) Trends in Pharmacological Sciences , vol.22 , Issue.8 , pp. 420-426
    • Danesi, R.1    De Braud, F.2    Fogli, S.3    Di Paolo, A.4    Del Tacca, M.5
  • 39
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics translating functional genomics into rational therapeutics
    • Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286, 487-491 (1999)
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 40
    • 33745876823 scopus 로고    scopus 로고
    • TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy?
    • DOI 10.1016/j.tips.2006.06.007, PII S0165614706001556
    • Maitland ML, Vasisht K, Ratain MJ. TPMT, UGT1A1 and DPYD: genotyping to ensure safer cancer therapy? Trends Pharmacol Sci 27, 432-437 (2006) (Pubitemid 44051569)
    • (2006) Trends in Pharmacological Sciences , vol.27 , Issue.8 , pp. 432-437
    • Maitland, M.L.1    Vasisht, K.2    Ratain, M.J.3
  • 42
    • 62649112146 scopus 로고    scopus 로고
    • EGFR-targeted therapies in lung cancer predictors of response and toxicity
    • Heist RS, Christiani D. EGFR-targeted therapies in lung cancer: predictors of response and toxicity. Pharmacogenomics 10, 59-68, (2009)
    • (2009) Pharmacogenomics , vol.10 , pp. 59-68
    • Heist, R.S.1    Christiani, D.2
  • 43
    • 33947588763 scopus 로고    scopus 로고
    • Should DPD analysis be required prior to prescribing fluoropyrimidines?
    • DOI 10.1016/j.ejca.2007.01.030, PII S0959804907000950
    • Yen JL, McLeod HL. Should DPD analysis be required prior to prescribing fluoropyrimidines? Eur J Cancer 43, 1011-1016 (2007) (Pubitemid 46483039)
    • (2007) European Journal of Cancer , vol.43 , Issue.6 , pp. 1011-1016
    • Yen, J.L.1    McLeod, H.L.2
  • 44
    • 36549011401 scopus 로고    scopus 로고
    • Severe or lethal toxicities upon capecitabine intake: is DPYD genetic polymorphism the ideal culprit?
    • DOI 10.1016/j.tips.2007.09.009, PII S0165614707002520
    • Mercier C, Ciccolini J. Severe or lethal toxicities upon capecitabine intake: Is DPYD genetic polymorphism the ideal culprit? Trends Pharmacol Sci 28, 597-598 (2007) (Pubitemid 350176603)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.12 , pp. 597-598
    • Mercier, C.1    Ciccolini, J.2
  • 46
    • 77952505307 scopus 로고    scopus 로고
    • Impact of cytidine deaminase polymorphisms on toxicity after gemcitabine the question is still ongoing
    • [Epub ahead of print]
    • Giovannetti E, Tibaldi C, Falcone A, Danesi R, Peters GJ. Impact of Cytidine Deaminase Polymorphisms on Toxicity After Gemcitabine: The Question Is Still Ongoing. J Clin Oncol [Epub ahead of print] (2010)
    • (2010) J Clin Oncol
    • Giovannetti, E.1    Tibaldi, C.2    Falcone, A.3    Danesi, R.4    Peters, G.J.5
  • 48
    • 0030990477 scopus 로고    scopus 로고
    • Competitive-differential polymerase chain reaction for gene dosage estimation of erbB-1 (egfr), erbB-2, and erbB-3 oncogenes
    • Roetger A, Brandt B, Barnekow A. Competitivedifferential polymerase chain reaction for gene dosage estimation of erbB-1 (egfr), erbB-2, and erbB-3 oncogenes. DNA Cell Biol 16, 443-448 (1997) (Pubitemid 27210443)
    • (1997) DNA and Cell Biology , vol.16 , Issue.4 , pp. 443-448
    • Roetger, A.1
  • 49
    • 11244319884 scopus 로고    scopus 로고
    • A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter
    • Liu W, Innocenti F, Wu MH, Desai AA, Dolan ME, Cook EH Jr, Ratain MJ. A functional common polymorphism in a Sp1 recognition site of the epidermal growth factor receptor gene promoter. Cancer Res 65, 46-53 (2005) (Pubitemid 40070794)
    • (2005) Cancer Research , vol.65 , Issue.1 , pp. 46-53
    • Liu, W.1    Innocenti, F.2    Wu, M.H.3    Desai, A.A.4    Dolan, M.E.5    Cook Jr., E.H.6    Ratain, M.J.7
  • 52
    • 0033914059 scopus 로고    scopus 로고
    • Modulation of EGFR gene transcription by secondary structures, a polymorphic repetitive sequence and mutations - A link between genetics and epigenetics
    • Gebhardt F, Bürger H, Brandt B. Modulation of EGFR gene transcription by secondary structures, a polymorphic repetitive sequence and mutations-a link between genetics and epigenetics. Histol Histopathol 15, 929-936 (2000) (Pubitemid 30488572)
    • (2000) Histology and Histopathology , vol.15 , Issue.3 , pp. 929-936
    • Gebhardt, F.1    Burger, H.2    Brandt, B.3
  • 53
    • 0040886242 scopus 로고    scopus 로고
    • Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1
    • Gebhardt F, Zänker KS, Brandt B. Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1. J Biol chem 274, 13176-13180 (1999)
    • (1999) J Biol Chem , vol.274 , pp. 13176-13180
    • Gebhardt, F.1    Zänker, K.S.2    Brandt, B.3
  • 54
    • 0034652578 scopus 로고    scopus 로고
    • Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression
    • Buerger H, Gebhardt F, Schmidt H, Beckmann A, Hutmacher K, Simon R, Lelle R, Boecker W, Brandt B. Length and loss of heterozygosity of an intron 1 polymorphic sequence of egfr is related to cytogenetic alterations and epithelial growth factor receptor expression. Cancer Res 60, 854-857 (2000) (Pubitemid 30129514)
    • (2000) Cancer Research , vol.60 , Issue.4 , pp. 854-857
    • Buerger, H.1    Gebhardt, F.2    Schmidt, H.3    Beckmann, A.4    Hutmacher, K.5    Simon, R.6    Lelle, R.7    Boecker, W.8    Brandt, B.9
  • 57
    • 34547841540 scopus 로고    scopus 로고
    • The epidermal growth factor receptor intron1 (CA) n microsatellite polymorphism is a potential predictor of treatment outcome in patients with advanced lung cancer treated with Gefitinib
    • DOI 10.1016/j.ejphar.2007.05.015, PII S0014299907006140
    • Nie Q, Wang Z, Zhang GC, An SJ, Lin JY, Guo AL, Li R, Gan B, Huang Y, Mok TS, Wu YL. The epidermal growth factor receptor intron 1 (CA)n microsatellite polymorphism is a potential predictor of treatment outcome in patients with advanced lung cancer treated with gefitinib. Eur J Pharmacol 570, 175-181 (2007) (Pubitemid 47247671)
    • (2007) European Journal of Pharmacology , vol.570 , Issue.1-3 , pp. 175-181
    • Nie, Q.1    Wang, Z.2    Zhang, G.-c.3    An, S.-j.4    Lin, J.-y.5    Guo, A.-l.6    Li, R.7    Gan, B.8    Huang, Y.9    Mok, T.S.10    Wu, Y.-l.11
  • 58
    • 40949096067 scopus 로고    scopus 로고
    • Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib
    • DOI 10.1038/sj.tpj.6500444, PII 6500444
    • Liu G, Gurubhagavatula S, Zhou W, Wang Z, Yeap BY, Asomaning K, Su L, Heist R, Lynch TJ, Christiani DC. Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small cell lung cancer patients treated with gefitinib. Pharmacogenomics J 8(2), 129-138 (2008) (Pubitemid 351411549)
    • (2008) Pharmacogenomics Journal , vol.8 , Issue.2 , pp. 129-138
    • Liu, G.1    Gurubhagavatula, S.2    Zhou, W.3    Wang, Z.4    Yeap, B.Y.5    Asomaning, K.6    Su, L.7    Heist, R.8    Lynch, T.J.9    Christiani, D.C.10
  • 62
    • 68949208058 scopus 로고    scopus 로고
    • Polymorphisms of EGFR predict clinical outcome in advanced non-small-cell lung cancer patients treated with Gefitinib
    • Ma F, Sun T, Shi Y, Yu D, Tan W, Yang M, Wu C, Chu D, Sun Y, Xu B, Lin D. Polymorphisms of EGFR predict clinical outcome in advanced non-small-cell lung cancer patients treated with Gefitinib. Lung Cancer 66(1), 114-119 (2009)
    • (2009) Lung Cancer , vol.66 , Issue.1 , pp. 114-119
    • Ma, F.1    Sun, T.2    Shi, Y.3    Yu, D.4    Tan, W.5    Yang, M.6    Wu, C.7    Chu, D.8    Sun, Y.9    Xu, B.10    Lin, D.11
  • 66
    • 43249115083 scopus 로고    scopus 로고
    • Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias
    • DOI 10.1038/sj.bjc.6604212, PII 6604212
    • Kim MS, Jeong EG, Yoo NJ, Lee SH. Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias. Br J Cancer 98, 1533-1535 (2008) (Pubitemid 351652321)
    • (2008) British Journal of Cancer , vol.98 , Issue.9 , pp. 1533-1535
    • Kim, M.S.1    Jeong, E.G.2    Yoo, N.J.3    Lee, S.H.4
  • 68
    • 0842310838 scopus 로고    scopus 로고
    • Convergent evidence for impaired AKT1-GSK3β signaling in schizophrenia
    • DOI 10.1038/ng1296
    • Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nat Genet 36, 131-137 (2004) (Pubitemid 38174370)
    • (2004) Nature Genetics , vol.36 , Issue.2 , pp. 131-137
    • Emamian, E.S.1    Hall, D.2    Birnbaum, M.J.3    Karayiorgou, M.4    Gogos, J.A.5
  • 69
    • 60849109531 scopus 로고    scopus 로고
    • Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcome in esophageal cancer patients treated with chemotherapy
    • Hildebrandt MA, Yang H, Hung MC, Izzo JG, Huang M, Lin J, Ajani JA, Wu X. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcome in esophageal cancer patients treated with chemotherapy. J Clin Oncol 27, 857-871 (2009)
    • (2009) J Clin Oncol , vol.27 , pp. 857-871
    • Hildebrandt, M.A.1    Yang, H.2    Hung, M.C.3    Izzo, J.G.4    Huang, M.5    Lin, J.6    Ajani, J.A.7    Wu, X.8
  • 70
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: Is there a silver lining?
    • DOI 10.1200/JCO.2005.00.6916
    • Perez-Soler R, Saltz L. Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining? J Clin Oncol 23, 5235-5246 (2005) (Pubitemid 46224035)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.22 , pp. 5235-5246
    • Perez-Soler, R.1    Saltz, L.2
  • 73
    • 34250749285 scopus 로고    scopus 로고
    • Epidermal growth factor receptor R497K polymorphism is a favorable prognostic factor for patients with colorectal carcinoma
    • DOI 10.1158/1078-0432.CCR-06-2601
    • Wang WS, Chen PM, Chiou TJ, Liu JH, Lin JK, Lin TC, Wang HS, Su Y. Epidermal growth factor receptor R497K polymorphism is a favourable prognostic factor for patients with colorectal carcinoma. Clin Cancer Res 13, 3597-3604 (2007) (Pubitemid 46955121)
    • (2007) Clinical Cancer Research , vol.13 , Issue.12 , pp. 3597-3604
    • Wang, W.-S.1    Chen, P.-M.2    Chiou, T.-J.3    Liu, J.-H.4    Lin, J.-K.5    Lin, T.-C.6    Wang, H.-S.7    Su, Y.8
  • 75
    • 33750975065 scopus 로고    scopus 로고
    • The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis
    • DOI 10.1016/j.drup.2006.09.001, PII S1368764606000628
    • Assaraf YG. The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Drug Resist Updat 9, 227-246 (2006) (Pubitemid 44750843)
    • (2006) Drug Resistance Updates , vol.9 , Issue.4-5 , pp. 227-246
    • Assaraf, Y.G.1
  • 76
    • 40349098162 scopus 로고    scopus 로고
    • Drug transporters: Recent advances concerning BCRP and tyrosine kinase inhibitors
    • DOI 10.1038/sj.bjc.6604213, PII 6604213
    • Lemos C, Jansen G, Peters GJ. Drug transporters: recent advances concerning BCRP and tyrosine kinase inhibitors. Br J Cancer 98, 857-862 (2008) (Pubitemid 351341599)
    • (2008) British Journal of Cancer , vol.98 , Issue.5 , pp. 857-862
    • Lemos, C.1    Jansen, G.2    Peters, G.J.3
  • 78
    • 34548240764 scopus 로고    scopus 로고
    • Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients
    • Li J, Cusatis G, Brahmer J, Sparreboom A, Robey RW, Bates SE, Hidalgo M, Baker SD. Association of variant ABCG2 and the pharmacokinetics of epidermal growth factor receptor tyrosine kinase inhibitors in cancer patients. Cancer Biol Ther 6, 432-438 (2007) (Pubitemid 47328313)
    • (2007) Cancer Biology and Therapy , vol.6 , Issue.3 , pp. 432-438
    • Li, J.1    Cusatis, G.2    Brahmer, J.3    Sparreboom, A.4    Robey, R.W.5    Bates, S.E.6    Hidalgo, M.7    Baker, S.D.8
  • 83
    • 34249723218 scopus 로고    scopus 로고
    • Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer
    • DOI 10.1038/sj.onc.1210381, PII 1210381
    • Galizia G, Lieto E, De Vita F, Orditura M, Castellano P, Troiani T, Imperatore V, Ciardiello F. Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer. Oncogene 26(25), 3654-3660 (2007) (Pubitemid 46842715)
    • (2007) Oncogene , vol.26 , Issue.25 , pp. 3654-3660
    • Galizia, G.1    Lieto, E.2    De Vita, F.3    Orditura, M.4    Castellano, P.5    Troiani, T.6    Imperatore, V.7    Ciardiello, F.8
  • 88
    • 33747045242 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) induces apoptosis in a transfected cell line expressing EGF receptor on its membrane
    • DOI 10.1016/j.cellbi.2006.04.004, PII S106569950600093X
    • Zhao X, Dai W, Zhu H, Zhang Y, Cao L, Ye Q, Lei P, Shen G. Epidermal growth factor (EGF) induces apoptosisin a transfected cell line expressing EGF receptor on its membrane. Cell Biol Int 30, 653-658 (2006) (Pubitemid 44209330)
    • (2006) Cell Biology International , vol.30 , Issue.8 , pp. 653-658
    • Zhao, X.1    Dai, W.2    Zhu, H.3    Zhang, Y.4    Cao, L.5    Ye, Q.6    Lei, P.7    Shen, G.8
  • 92
    • 0029776415 scopus 로고    scopus 로고
    • 1 arrest in prostatic cancer cell line DU145
    • Peng D, Fan Z, Lu Y, DeBlasio T, Scher H, Mendelsohn J. Anti-epidermal growth factor receptor monoclonal antibody 225 up-regulates p27KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res 56(16), 3666-3669 (1996) (Pubitemid 26272010)
    • (1996) Cancer Research , vol.56 , Issue.16 , pp. 3666-3669
    • Peng, D.1    Fan, Z.2    Lu, Y.3    DeBlasio, T.4    Scher, H.5    Mendelsohn, J.6
  • 93
    • 2542425542 scopus 로고    scopus 로고
    • Gene expression profiling in non-small cell lung cancer: From molecular mechanisms to clinical application
    • DOI 10.1158/1078-0432.CCR-03-0503
    • Petty RD, Nicolson MC, Kerr KM, Collie-Duguid E, Murray GI. Gene expression profiling in non-small cell lung cancer: from molecular mechanisms to clinical application. Clin Cancer Res 10, 3237-3248 (2004) (Pubitemid 38685427)
    • (2004) Clinical Cancer Research , vol.10 , Issue.10 , pp. 3237-3248
    • Petty, R.D.1    Nicolson, M.C.2    Kerr, K.M.3    Collie-Duguid, E.4    Murray, G.I.5
  • 94
    • 0642373290 scopus 로고    scopus 로고
    • Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    • DOI 10.1200/JCO.2003.05.013
    • Weng WK, Levy R. Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol 21, 3940-3947 (2003) (Pubitemid 46606207)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.21 , pp. 3940-3947
    • Weng, W.-K.1    Levy, R.2
  • 95
    • 69049115069 scopus 로고    scopus 로고
    • Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells
    • López-Albaitero A, Lee SC, Morgan S, Grandis JR, Gooding WE, Ferrone S, Ferris RL. Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells. Cancer Immunol 58, 1853-1864 (2009)
    • (2009) Cancer Immunol , vol.58 , pp. 1853-1864
    • López-Albaitero, A.1    Lee, S.C.2    Morgan, S.3    Grandis, J.R.4    Gooding, W.E.5    Ferrone, S.6    Ferris, R.L.7
  • 96
    • 74949098030 scopus 로고    scopus 로고
    • Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment
    • Klinghammer K, Knödler M, Schmittel A, Budach V, Keilholz U, Tinhofer I. Association of epidermal growth factor receptor polymorphism, skin toxicity, and outcome in patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment. Clin Cancer Res 16, 304-310 (2010)
    • (2010) Clin Cancer Res , vol.16 , pp. 304-310
    • Klinghammer, K.1    Knödler, M.2    Schmittel, A.3    Budach, V.4    Keilholz, U.5    Tinhofer, I.6


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