DNA methylation and the expression of IL-4 and IFN-γ promoter genes in patients with bronchial asthma

Journal of Clinical Immunology

Volumn 28, Issue 2, 2008, Pages 139-146

  Kwon, Nam Hee ^a   Kim, Jin Seuk ^b   Lee, Jin Young ^a   Oh, Mi Jung ^a   Choi, Dong Chull ^a  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Samsung Medical Center   (South Korea)

Author keywords

Bronchial asthma; IFN ; IL 4; Methylation

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4; PHYTOHEMAGGLUTININ;

ADULT; ALLERGIC ASTHMA; ARTICLE; CASE REPORT; CD4+ T LYMPHOCYTE; CLINICAL FEATURE; CONTROLLED STUDY; CORRELATION ANALYSIS; CPG ISLAND; DERMATOPHAGOIDES FARINAE; DERMATOPHAGOIDES PTERONYSSINUS; DNA METHYLATION; DNA SEQUENCE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL;

ADULT; ANTIGENS, DERMATOPHAGOIDES; ASTHMA; CD4-POSITIVE T-LYMPHOCYTES; DNA METHYLATION; FEMALE; GENE EXPRESSION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MALE; PHYTOHEMAGGLUTININS; PROMOTER REGIONS (GENETICS);

EID: 40149105740     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-007-9148-1     Document Type: Article

References (27)

1. Agnello D, Lankford CS, Bream J, Morinobu A, Gadina M, O'Shea JJ, et al. Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J Clin Immunol. 2003;23:147-61.
2. Smart JM, Kemp AS. Increased Th1 and Th2 allergen-induced cytokine responses in children with atopic disease. Clin Exp Allergy. 2002;32:796-802.
3. Robinson DS. The Th1 and Th2 concept in atopic allergic disease. Chem Immunol. 2000;78:50-61.
4. Robinson DS. Th-2 cytokines in allergic disease. Br Med Bull. 2000;56:956-68.
5. Kimura M, Tsuruta S, Yoshida T. Unique profile of IL-4 and IFN-gamma production by peripheral blood mononuclear cells in infants with atopic dermatitis. J Allergy Clin Immunol. 1998;102:238-44.
6. Maggi E, Parronchi P, Manetti R, Simonelli C, Piccinni MP, Rugiu FS, et al. Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol. 1992;148:2142-7.
7. Smart JM, Horak E, Kemp AS, Robertson CF, Tang ML. Polyclonal and allergen-induced cytokine responses in adults with asthma: resolution of asthma is associated with normalization of IFN-gamma responses. J Allergy Clin Immunol. 2002;110:450-6.
8. Rudin A, Macaubas C, Wee C, Holt BJ, Slya PD, Holt PG. "Bystander" amplification of PBMC cytokine responses to seasonal allergen in polysensitized atopic children. Allergy. 2001;56:1042-8.
9. Nurse B, Puterman AS, Haus M, Berman D, Weinberg EG, Potter PC. PBMCs from both atopic asthmatic and nonatopic children show a TH2 cytokine response to house dust mite allergen. J Allergy Clin Immunol. 2000;106:84-91.
10. Wilson CB, Makar KW, Shnyreva M, Fitzpatrick DR. DNA methylation and the expanding epigenetics of T cell lineage commitment. Semin Immunol. 2005;17:105-19.
11. Fitzpatrick DR, Wilson CB. Methylation and demethylation in the regulation of genes, cells, and responses in the immune system. Clin Immunol. 2003;109:37-45.
12. Smale ST, Fisher AG. Chromatin structure and gene regulation in the immune system. Annu Rev Immunol. 2002;20:427-62.
13. Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet. 2002;3:662-73.
14. Young HA, Ghosh P, Ye J, Lederer J, Lichtman A, Gerard JR, et al. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene. J Immunol. 1994;153:3603-10.
15. White GP, Watt PM, Holt BJ, Holt PG. Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells. J Immunol. 2002;168:2820-7.
16. Yano S, Ghosh P, Kusaba H, Buchholz M, Longo DL. Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J Immunol. 2003;171:2510-6.
17. Agarwal S, Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity. 1998;9:765-75.
18. Santangelo S, Cousins DJ, Winkelmann NE, Staynov DZ. DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation. J Immunol. 2002;169:1893-903.
19. Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity. 2001;14:205-15.
20. Ansel KM, Lee DU, Rao A. An epigenetic view of helper T cell differentiation. Nat Immunol. 2003;4:616-23.
21. Makar KW, Perez-Melgosa M, Shnyreva M, Weaver WM, Fitzpatrick DR, Wilson CB. Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cells. Nat Immunol. 2003;4:1183-90.
22. Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol. 2002;2:933-44.
23. Lee DU, Agarwal S, Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity. 2002;16:649-60.
24. Fields PE, Lee GR, Kim ST, Bartsevich VV, Flavell RA. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity. 2004;21:865-76.
25. Falek PR, Ben-Sasson SZ, Ariel M. Correlation between DNA methylation and murine IFN-gamma and IL-4 expression. Cytokine. 2000;12:198-206.
26. Winders BR, Schwartz RH, Bruniquel D. A distinct region of the murine IFN-gamma promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells. J Immunol. 2004;173:7377-84.
27. Makar KW, Wilson CB. DNA methylation is a nonredundant repressor of the Th2 effector program. J Immunol. 2004;173:4402-6.