Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids

Molecular Pharmacology

Volumn 71, Issue 1, 2007, Pages 132-144

  Cuzzocrea, Salvatore ^a,b   Bruscoli, Stefano ^c   Crisafulli, Concetta ^a   Mazzon, Emanuela ^a,b   Agostini, Massimiliano ^c   Muià, Carmelo ^a   Esposito, Emanuela ^d   Di Virgilio, Rosa ^c   Meli, Rosaria ^d   Vegeto, Elisabetta ^e   Maggi, Adriana ^e   Riccardi, Carlo ^c  

^a UNIVERSITY OF MESSINA   (Italy)

^b IRCCS CENTRO NEUROLESI BONINO PULEJO   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

^d UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^e UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ANTAGONIST; FULVESTRANT; GLUCOCORTICOID RECEPTOR; TAMOXIFEN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; FEMALE; LIPID PEROXIDATION; NONHUMAN; PLEURISY; PNEUMONIA; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DEXAMETHASONE; DINOPROSTONE; DNA PRIMERS; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; GLUCOCORTICOIDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR CROSS-TALK; RECEPTORS, ESTROGEN; RECEPTORS, GLUCOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33845897370     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.029629     Document Type: Article

References (46)

1. Almawi WY, Beyhum HN, Rahme AA, and Rieder MJ (1996) Regulation of cytokine and cytokine receptor expression by glucocorticoids. J Leukoc Biol 60:563-572.
2. Barnes PJ and Adcock I (1993) Anti-inflammatory actions of steroids: molecular mechanisms. Trends Pharmacol Sci 14:436-441.
3. Batuman OA, Ferrero A, Cupp C, Jimenez SA, and Khalili K (1995) Differential regulation of transforming growth factor beta-1 gene expression by glucocorticoids in human T and glial cells. J Immunol 155:4397-4405.
4. Christman JW, Lancaster LH, and Blackwell TS (1998) Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med 24:1131-1138.
5. Cupps TR, Edgar LC, and Fauci AS (1982) Corticosteroid-induced modulation of immunoglobulin secretion by human B lymphocytes: potentiation of background mitogenic signals. J Immunopharmacol 4:255-263.
6. Cuzzocrea S, Mazzon E, Bevilaqua C, Costantino G, Britti D, Mazzullo G, De Sarro A, and Caputi AP (2000a) Cloricromene, a coumarine derivative, protects against collagen-induced arthritis in Lewis rats. Br J Pharmacol 131:1399-1407.
7. Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Ciccolo A, Centorrino T, De Sarro A, and Caputi AP (2001a) Protective effects of N-acetylcysteine on lung injury and red blood cell modification induced by carrageenan in the rat. FASEB J 15:1187-1200.
8. Cuzzocrea S, Mazzon E, Sautebin L, Serraino I, Dugo L, Calabro G, Caputi AP, and Maggi A (2001b) The protective role of endogenous estrogens in carrageenan-induced lung injury in the rat. Mol Med 7:478-487.
9. Cuzzocrea S, Riley DP, Caputi AP, and Salvemini D (2001c) Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev 53:135-159.
10. Cuzzocrea S, Santagati S, Sautebin L, Mazzon E, Calabro G, Serraino I, Caputi AP, and Maggi A (2000b) 17beta-estradiol antiinflammatory activity in carrageenan-induced pleurisy. Endocrinology 141:1455-1463.
11. Cuzzocrea S, Tan DX, Costantino G, Mazzon E, Caputi AP, and Reiter RJ (1999) The protective role of endogenous melatonin in carrageenan-induced pleurisy in the rat. FASEB J 13:1930-1938.
12. D'Adamio F, Zollo O, Moraca R, Ayroldi E, Bruscoli S, Bartoli A, Cannarile L, Migliorati G, and Riccardi C (1997) A new DEX-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity 7:803-812.
13. Dostert A and Heinzel T (2004) Negative glucocorticoid receptor response elements and their role in glucocorticoid action. Curr Pharm Des 10:2807-2816.
14. Eiserich JP, Cross CE, Jones AD, Halliwell B, and van der Vliet A (1996) Formation of nitrating and chlorinating species by reaction of nitrite with hypochlorous acid. A novel mechanism for nitric oxide-mediated protein modification. J Biol Chem 271:19199-19208.
15. Flower RJ and Rothwell NJ (1994) Lipocortin-1: cellular mechanisms and clinical relevance. Trends Pharmacol Sci 15:71-76.
16. Fushimi T, Shimura S, Suzuki S, Saitoh H, Okayama H, and Shirato K (1998) Suppression of gene expression and production of interleukin 13 by DEX in human peripheral blood mononuclear cells. Tohoku J Exp Med 185:157-160.
17. Gallagher JC, Fowler SE, Detter JR, and Sherman SS (2001) Combination treatment with estrogen and calcitriol in the prevention of age-related bone loss. J Clin Endocrinol Metab 86:3618-3628.
18. Ghisletti S, Meda C, Maggi A, and Vegeto E (2005) 17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization. Mol Cell Biol 25:2957-2968.
19. Hoyos S, Granell S, Heredia N, Bulbena O, Closa D, Fernandez-Cruz L (2005) Influence of portal blood on the development of systemic inflammation associated with experimental acute pancreatitis. Surgery 137:186-191.
20. Iuvone T, Van Osselaer N, D'Acquisto F, Carnuccio R, Herman AG (1997) Differential effect of L-NAME and S-methyl-isothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat. Br J Pharmacol 121:1637-1644.
21. Jun SS, Chen Z, Pace MC, Shaul PW (1999) Glucocorticoids downregulate cyclooxygenase-1 gene expression and prostacyclin synthesis in fetal pulmonary artery endothelium. Circ Res 84:193-200.
22. Kadl A, Leitinger N (2005) The role of endothelial cells in the resolution of acute inflammation. Antioxid Redox Signal 7:1744-1754.
23. Kunicka JE, Talle MA, Denhardt GH, Brown M, Prince LA, and Goldstein G (1993) Immunosuppression by glucocorticoids: inhibition of production of multiple lymphokines by in vivo administration of DEX. Cell Immunol 149:39-49.
24. Klock G, Strahle U, and Schutz G (1987) Oestrogen and glucocorticoid responsive elements are closely related but distinct. Nature (Lond) 329:734-736.
25. Mader S, Kumar V, de Verneuil H, and Chambon P (1989) Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element. Nature (Lond) 338:271-274.
26. Miyasaka K and Mikami T (1982) Comparison of the anti-inflammatory effects of DEX, indomethacin and BW755C on carrageenin-induced pleurisy in rats. Eur J Pharmacol 77:229-236.
27. Molero L, Garcia-Duran M, Diaz-Recasens J, Rico L, Casado S, and Lopez-Farre A (2002) Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men: regulation by estrogen. Cardiovasc Res 56:43-51.
28. Mukherjee D (2002) Selective cyclooxygenase-2 (COX-2) inhibitors and potential risk of cardiovascular events. Biochem Pharmacol 63:817-821.
29. Mullane KM, Kraemer R, and Smith B (1985) Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-167.
30. Nakatsugi S, Terada N, Yoshimura T, Horie Y, and Furukawa M (1996) Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress-induced gastric lesions in rats. Prostaglandins Leukot Essent Fatty Acids 55:395-402.
31. Nantel F, Denis D, Gordon R, Northey A, Cirino M, Metters KM, and Chan CC (1999) Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. Br J Pharmacol 128:853-859.
32. Ohkawa H, Ohishi N, and Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358.
33. Ozawa H (2005) Steroid Hormones, their receptors and neuroendocrine system. J Nippon Med Sch 72:316-325.
34. Posadas I, Bucci M, Roviezzo F, Rossi A, Parente L, Sautebin L, and Cirino G (2004) Carrageenan-induced mouse paw oedema is biphasic, age-weight dependent and displays differential nitric oxide cyclooxygenase-2 expression. Br J Pharmacol 142:331-338.
35. Rackoff PJ and Rosen CJ (1998) Pathogenesis and treatment of glucocorticoid-induced osteoporosis. Drugs Aging 12:477-484.
36. Riccardi C, Bruscoli S, and Migliorati G (2002) Molecular mechanisms of immunomodulatory activity of glucocorticoids. Pharmacol Res 45:361-368.
37. Salvemini D, Wang ZQ, Bourdon DM, Stern MK, Currie MG, and Manning PT (1996) Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edema. Eur J Pharmacol 303:217-220.
38. Schramm R and Thorlacius H (2004) Neutrophil recruitment in mast cell-dependent inflammation: inhibitory mechanisms of glucocorticoids. Inflamm Res 53:644-652.
39. Sengupta S and Wasylyk B (2001) Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2. Genes Dev 15:2367-2380.
40. Sutherland RL, Prall OW, Watts CK, and Musgrove EA (1998) Estrogen and progestin regulation of cell cycle progression. J Mammary Gland Biol Neoplasia 3:63-72.
41. Szabo C (1997) Role of poly(ADP-ribose) synthetase activation in the suppression of cellular energetics in response to nitric oxide and peroxynitrite. Biochem Soc Trans 25:919-924.
42. Uht RM, Anderson CM, Webb P, and Kushner PJ (1997) Transcriptional activities of estrogen and GRare functionally integrated at the AP-1 response element. Endocrinology 138:2900-2908.
43. Vane J and Botting R (1987) Inflammation V and the mechanism of action of antiinflammatory drugs. FASEB 1:89-96.
44. Vegeto E, Belcredito S, Etteri S, Ghisletti S, Brusadelli A, Meda C, Krust A, Dupont S, Ciana P, Chambon P, et al. (2003) Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci USA 100:9614-9619.
45. Webb P, Lopez GN, Uht RM, and Kushner PJ (1995) Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens. Mol Endocrinol 9:443-456.
46. Zhou F, Bouillard B, Pharaboz-Joly MO, and Andre J (1989) Non-classical antiestrogenic actions of DEX in variant MCF-7 human breast cancer cells in culture. Mol Cell Endocrinol 66:189-197.