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Volumn 17, Issue 19, 2011, Pages 5256-5260

New cathepsin inhibitors to explore the fluorophilic properties of the S2 pocket of cathepsin B: Design, synthesis, and biological evaluation

(12) Fustero, Santos a,b Rodrigo, Vanessa b Sánchez Rosellõ, María b Del Pozo, Carlos a Timoneda, Joaquín a Frizler, Maxim c,d Sisay, Mihiret T c Bajorath, Jürgen c Calle, Luis P e Cañada, F Javier e Jiménez Barbero, Jesãs e Gütschow, Michael c,d

a UNIVERSITY OF VALENCIA (Spain)

b CENTRO DE INVESTIGACIÓN PRÍNCIPE FELIPE (Spain)

c UNIVERSITY OF BONN (Germany)

d NRW International Graduate Research School Biotech (Germany)

e CENTRO DE INVESTIGACIONES BIOLÓGICAS (Spain)

Author keywords

fluorinated ligands; hydrolases; inhibitors; peptides; stereoselectivity

Indexed keywords

BIOLOGICAL EVALUATION; CATHEPSIN B; CYCLOALIPHATIC; DIFLUORINATED; DIPEPTIDE; FLUORINATED LIGANDS; FLUORINE ATOMS; INHIBITORS; NMR STUDIES; PROTEIN STRUCTURES;

AMINO ACIDS; CYANIDES; ENZYMES; FLUORINE; HYDROLASES; MOLECULAR ORIENTATION; PEPTIDES; STEREOSELECTIVITY;

LIGANDS;

CATHEPSIN B; DIPEPTIDE; FLUORINATED HYDROCARBON; NITRILE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; HUMAN; STEREOISOMERISM; SYNTHESIS;

CATHEPSIN B; COMBINATORIAL CHEMISTRY TECHNIQUES; DIPEPTIDES; DRUG DESIGN; HUMANS; HYDROCARBONS, FLUORINATED; MOLECULAR STRUCTURE; NITRILES; STEREOISOMERISM;

EID: 79955005064 PISSN: 09476539 EISSN: 15213765 Source Type: Journal
DOI: 10.1002/chem.201100113 Document Type: Article

Times cited : (13)

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