The fate and toxicity of raman-active silica-gold nanoparticles in mice

Science Translational Medicine

Volumn 3, Issue 79, 2011, Pages

  Thakor, Avnesh S ^a,b   Luong, Richard ^c   Paulmurugan, Ramasamy ^a   Lin, Frank I ^a   Kempen, Paul ^d   Zavaleta, Cristina ^a   Chu, Pauline ^c   Massoud, Tarik F ^a,b   Sinclair, Robert ^d   Gambhir, Sanjiv S ^a,c,d  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c STANFORD UNIVERSITY   (United States)

^d Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; GOLD NANOPARTICLE; MACROGOL; SILICON DIOXIDE; GOLD; MACROGOL DERIVATIVE; METAL NANOPARTICLE;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR PARAMETERS; COLORECTAL CANCER; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; FEMALE; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MOUSE; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BINDING; RAMAN SPECTROMETRY; RETICULOENDOTHELIAL SYSTEM; TOXICITY TESTING; ANIMAL; CHEMISTRY; METABOLISM; METHODOLOGY;

ANIMALS; FEMALE; GOLD; MALE; METAL NANOPARTICLES; MICE; POLYETHYLENE GLYCOLS; SILICON DIOXIDE; SPECTRUM ANALYSIS, RAMAN;

EID: 79954995449     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3001963     Document Type: Article

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36. Acknowledgments: We thank I. Walton (Oxonica Inc.) for helpful advice. We also thank A. Patri and colleagues at the Nanocharacterization Lab (NCL), National Cancer Institute (NCI) at Frederick. Funding: Supported by the NCI Center for Cancer Nanotechnology Excellence (CCNE) U54 CA119367 (S.S.G.), NCI Network for Translational Research (NTR): Optical Imaging in Multimodality Platforms (S.S.G.), the NCI In Vivo Cellular and Molecular Imaging Centers (ICMIC) P50 CA114747 (S.S.G.), the Canary Foundation (S.S.G.), the American Cancer Society (A.S.T.), the European Association for Cancer Research (A.S.T.), Ben and Catherine Ivy Foundation (S.S.G.), the PEEL Medical Research Trust (A.S.T.), and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (A.S.T. and T.F.M.). Author contributions: A.S.T. designed and performed all experiments, analyzed all the data, and wrote the paper; R.L. performed histological experiments and data analysis; R.P. performed gene expression experiments and data analysis; F.I.L. performed ICP-MS experiments and data analysis; P.K. performed STEM experiments and data analysis; C.Z. designed and performed experiments; P.C. performed immunohistochemistry and TUNEL assay experiments; T.F.M. designed experiments and helped write the paper; R.S. performed STEM experiments; S.S.G. designed all experiments, analyzed all the data, and wrote the paper. Competing interests: The authors declare that they have no competing interests. Cabot Security Inc. (formerly Oxonica Inc.) sells the gold/silica nanoparticles used in this work and may restrict their applications. The authors have no financial interest/ties to this company. S.S.G. serves as an advisor to Nine Point Medical, which may eventually work on in vivo Raman imaging using the nanoparticles that are a subject of this work but currently have not licensed the particles or their in vivo use from Stanford University and Cabot Security.