Regulation of transforming growth factor-β1-dependent integrin β6 expression by p38 mitogen-activated protein kinase in bile duct epithelial cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 2, 2011, Pages 471-478

  Sullivan, Bradley P ^a   Kassel, Karen M ^a   Manley, Sharon ^a   Baker, Alyson K ^a   Luyendyk, James P ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA6 INTEGRIN; CYCLOHEXIMIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BILE DUCT; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME INHIBITION; EPITHELIUM CELL; GENE CONSTRUCT; GENE EXPRESSION REGULATION; GENETIC TRANSFORMATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; SIGNAL TRANSDUCTION;

BILE DUCTS; BLOTTING, WESTERN; CELL LINE; CYTOSOL; DENSITOMETRY; DNA, COMPLEMENTARY; EPITHELIAL CELLS; HUMANS; IMMUNOPRECIPITATION; INTEGRIN BETA CHAINS; LUCIFERASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79954989615     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.177337     Document Type: Article

References (40)

1. Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, and Cohen P (2007) The selectivity of protein kinase inhibitors: A further update. Biochem J 408:297-315.
2. Bataller R and Brenner DA (2005) Liver fibrosis. J Clin Invest 115:209-218. (Pubitemid 40385459)
3. Breuss JM, Gallo J, DeLisser HM, Klimanskaya IV, Folkesson HG, Pittet JF, Nishimura SL, Aldape K, Landers DV, and Carpenter W (1995) Expression of the β6 integrin subunit in development, neoplasia and tissue repair suggests a role in epithelial remodeling. J Cell Sci 108:2241-2251.
4. Brown PH, Alani R, Preis LH, Szabo E, and Birrer MJ (1993) Suppression of oncogene-induced transformation by a deletion mutant of c-jun. Oncogene 8:877-886. (Pubitemid 23087418)
5. Brown PH, Chen TK, and Birrer MJ (1994) Mechanism of action of a dominantnegative mutant of c-Jun. Oncogene 9:791-799. (Pubitemid 24065917)
6. Coussens LM, Yokoyama K, and Chiu R (1994) Transforming growth factor β1-mediated induction of junB is selectively inhibited by expression of Ad.12-E1A. J Cell Physiol 160:435-444. (Pubitemid 24288901)
7. Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SM, Lawler J, Hynes RO, Boivin GP, and Bouck N (1998) Thrombospondin-1 is a major activator of TGF-β1 in vivo. Cell 93:1159-1170. (Pubitemid 28307421)
8. Derynck R and Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425:577-584. (Pubitemid 37280136)
9. Edlund S, Bu S, Schuster N, Aspenström P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH, and Landström M (2003) Transforming growth factor-β1 (TGF-β)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-β-activated kinase 1 and mitogen-activated protein kinase kinase 3. Biol Cell. 14:529-544. (Pubitemid 36237014)
10. Hahm K, Lukashev ME, Luo Y, Yang WJ, Dolinski BM, Weinreb PH, Simon KJ, Chun Wang L, Leone DR, Lobb RR, et al. (2007) αvβ6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol 170:110-125. (Pubitemid 47342405)
11. Holmes A, Abraham DJ, Sa S, Shiwen X, Black CM, and Leask A (2001) CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem 276:10594-10601. (Pubitemid 38089227)
12. Humar M, Loop T, Schmidt R, Hoetzel A, Roesslein M, Andriopoulos N, Pahl HL, Geiger KK, and Pannen BH (2007) The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun. Int J Biochem Cell Biol 39:2278-2288. (Pubitemid 47484282)
13. Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, and O'Keefe RJ (2003) ATF-2 cooperates with Smad3 to mediate TGF-β effects on chondrocyte maturation. Exp Cell Res 288:198-207. (Pubitemid 36871009)
14. Javelaud D and Mauviel A (2005) Crosstalk mechanisms between the mitogenactivated protein kinase pathways and Smad signaling downstream of TGF-β: Implications for carcinogenesis. Oncogene 24:5742-5750. (Pubitemid 43086134)
15. Jenkins RG, Su X, Su G, Scotton CJ, Camerer E, Laurent GJ, Davis GE, Chambers RC, Matthay MA, and Sheppard D (2006) Ligation of protease-activated receptor 1 enhances αvβ6 integrin-dependent TGF-β activation and promotes acute lung injury. J Clin Invest 116:1606-1614.
16. Kumar S, McDonnell PC, Gum RJ, Hand AT, Lee JC, and Young PR (1997) Novel homologues of CSBP/p38 MAP kinase: Activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun 235: 533-538. (Pubitemid 27326515)
17. Laiho M, Rönnstrand L, Heino J, Decaprio JA, Ludlow JW, Livingston DM, and Massagué J (1991) Control of junB and extracellular matrix protein expression by transforming growth factor-β1 is independent of simian virus 40 T antigensensitive growth-sensitive growth-inhibitory events. Mol Cell Biol 11:972-978. (Pubitemid 21895447)
18. Levy L and Hill CS (2005) Smad4 dependency defines two classes of transforming growth factor (TGF-β) target genes and distinguishes TGF-β-induced epithelialmesenchymal transition from its antiproliferative and migratory responses. Mol Cell Biol 25:8108-8125. (Pubitemid 41263004)
19. 3 fibroblasts. Biochem Biophys Res Commun 151: 298-305.
20. Lu JP, Mao JQ, Li MS, Lu SL, Hu XQ, Zhu SN, and Nomura S (2003) In situ detection of TGF βs, TGF β receptor II mRNA and telomerase activity in rat cholangiocarcinogenesis. World J Gastroenterol 9:590-594. (Pubitemid 36372132)
21. Luo B, Tang L, Wang Z, Zhang J, Ling Y, Feng W, Sun JZ, Stockard CR, Frost AR, Chen YF, et al. (2005) Cholangiocyte endothelin 1 and transforming growth factor β1 production in rat experimental hepatopulmonary syndrome. Gastroenterology 129:682-695. (Pubitemid 41096652)
22. Marsh D, Dickinson S, Neill GW, Marshall JF, Hart IR, and Thomas GJ (2008) αvβ6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. Cancer Res 68:3295-3303.
23. Motulsky H (1995) Intuitive Biostatistics. Oxford University Press, New York.
24. Munger JS, Huang X, Kawakatsu H, Griffiths MJ, Dalton SL, Wu J, Pittet JF, Kaminski N, Garat C, Matthay MA, et al. (1999) The integrin αvβ6 binds and activates latent TGF β1: A mechanism for regulating pulmonary inflammation and fibrosis. Cell 96:319-328. (Pubitemid 29077586)
25. Ohshima T and Shimotohno K (2003) Transforming growth factor-β-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4. J Biol Chem 278:50833-50842. (Pubitemid 38020313)
26. Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, and Schuppan D (2008) Inhibition of integrin αvβ6 on cholangiocytes blocks transforming growth factor-β activation and retards biliary fibrosis progression. Gastroenterology 135:660-670.
27. Phanish MK, Wahab NA, Colville-Nash P, Hendry BM, and Dockrell ME (2006) The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFβ1 responses in human proximal-tubule epithelial cells. Biochem J 393:601-607. (Pubitemid 43099100)
28. Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, Kolb A, Friess H, and Schuppan D (2008) Integrin αvβ6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol 48:453-464.
29. Schnabl B, Kweon YO, Frederick JP, Wang XF, Rippe RA, and Brenner DA (2001) The role of Smad3 in mediating mouse hepatic stellate cell activation. Hepatology 34:89-100. (Pubitemid 32591487)
30. Sedlaczek N, Jia JD, Bauer M, Herbst H, Ruehl M, Hahn EG, and Schuppan D (2001) Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am J Pathol 158:1239-1244. (Pubitemid 32281287)
31. Selvamurugan N, Kwok S, and Partridge NC (2004) Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-β1-stimulated collagenase-3 expression in human breast cancer cells. J Biol Chem 279:27764-27773. (Pubitemid 38812618)
32. Shanware NP, Williams LM, Bowler MJ, and Tibbetts RS (2009) Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190. BMB Rep 42:142-147.
33. Shaulian E and Karin M (2001) AP-1 in cell proliferation and survival. Oncogene 20:2390-2400. (Pubitemid 32531297)
34. Sullivan BP, Weinreb PH, Violette SM, and Luyendyk JP (2010) The coagulation system contributes to αvβ6 integrin expression and liver fibrosis induced by cholestasis. Am J Pathol 177:2837-2849.
35. Verrecchia F, Vindevoghel L, Lechleider RJ, Uitto J, Roberts AB, and Mauviel A (2001) Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific manner. Oncogene 20:3332-3340. (Pubitemid 32588981)
36. Wang B, Dolinski BM, Kikuchi N, Leone DR, Peters MG, Weinreb PH, Violette SM, and Bissell DM (2007a) Role of αvβ6 integrin in acute biliary fibrosis. Hepatology 46:1404-1412. (Pubitemid 350155522)
37. Wang H, Zhang Y, and Heuckeroth RO (2007b) PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA. FEBS Lett 581:3098-3104. (Pubitemid 46899037)
38. Yamamura Y, Hua X, Bergelson S, and Lodish HF (2000) Critical role of Smads and AP-1 complex in transforming growth factor-β-dependent apoptosis. J Biol Chem 275:36295-36302.
39. Zhang Y, Feng X, We R, and Derynck R (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383:168-172. (Pubitemid 26303979)
40. Zhao J, Shi W, Wang YL, Chen H, Bringas P Jr, Datto MB, Frederick JP, Wang XF, and Warburton D (2002) Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol 282:L585-L593. (Pubitemid 34654664)