Endotoxin-induced mortality is related to increased oxidative stress and end-organ dysfunction, not refractory hypotension, in heme oxygenase-1-deficient mice

Circulation

Volumn 102, Issue 24, 2000, Pages 3015-3022

  Wiesel, Philippe ^a,c   Patel, Anand P ^a,c   DiFonzo, Nicole ^c   Marria, Pooja B ^c   Sim, Chäng U ^c   Pellacani, Andrea ^a,b,c   Maemura, Koji ^a,c   LeBlanc, Brian W ^c   Marino, Kathryn ^c   Doerschuk, Claire M ^c,d   Yet, Shaw Fang ^a,b,c   Lee, Mu En ^a,b,c   Perrella, Mark A ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endotoxin; Perfusion; Shock; Vasoconstriction

Indexed keywords

BILIRUBIN; CARBON MONOXIDE; ENDOTHELIN 1; ENDOTOXIN; HEME OXYGENASE; IRON; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VESSEL TONE; ENDOTOXEMIA; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME DEGRADATION; ENZYME INDUCTION; FEMALE; HYPERTENSION; KIDNEY DISEASE; LIPID PEROXIDATION; LIVER DYSFUNCTION; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SEPTIC SHOCK;

EID: 0034642320     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.24.3015     Document Type: Article

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