Animal models of human anxiety disorders: Reappraisal from a developmental psychopathology vantage point

Pediatric Research

Volumn 69, Issue 5 PART 2, 2011, Pages

  Lampis, Valentina ^a   Maziade, Michel ^b   Battaglia, Marco ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANXIETY DISORDER; ARTICLE; EPIGENETICS; GENOTYPE ENVIRONMENT INTERACTION; MEDICAL RESEARCH; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEOMICS; TECHNIQUE;

ANIMALS; ANXIETY; DISEASE MODELS, ANIMAL; HUMANS; NEUROPSYCHOLOGICAL TESTS;

EID: 79954586127     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e318212b42e     Document Type: Article

References (81)

1. Kendler KS, Hettema JM, Butera F, Gardner CO, Prescott CA 2003 Life event dimensions of loss, humiliation, entrapment, and danger in the prediction of onsets of major depression and generalized anxiety. Arch Gen Psychiatry 60:789-796 (Pubitemid 36960910)
2. Spatola CA, Fagnani C, Pesenti-Gritti P, Ogliari A, Stazi MA, Battaglia M 2007 A general population twin study of the CBCL/6-18 DSM-oriented scales. J Am Acad Child Adolesc Psychiatry 46:619-627 (Pubitemid 46642579)
3. Ogliari A, Spatola CA, Pesenti-Gritti P, Medda E, Penna L, Stazi MA, Battaglia M, Fagnani C 2010 The role of genes and environment in shaping co-occurrence of DSM-IV defined anxiety dimensions among Italian twins aged 8-17. J Anxiety Disord 24:433-439
4. Leonardo ED, Hen R 2006 Genetics of affective and anxiety disorders. Annu Rev Psychol 57:117-137 (Pubitemid 43237229)
5. Phelps EA, LeDoux JE 2005 Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 48:175-187 (Pubitemid 41476352)
6. Battaglia M, Ogliari A, Zanoni A, Citterio A, Pozzoli U, Giorda R, Maffei C, Marino C 2005 Influence of the serotonin transporter promoter gene and shyness on children's cerebral responses to facial expressions. Arch Gen Psychiatry 62:85-94 (Pubitemid 40096074)
7. Smoller JW, Paulus MP, Fagerness JA, Purcell S, Yamaki LH, Hirshfeld-Becker D, Biederman J, Rosenbaum JF, Gelernter J, Stein MB 2008 Influence of RGS2 on anxiety-related temperament, personality, and brain function. Arch Gen Psychiatry 65:298-308 (Pubitemid 351342446)
8. Plomin R, Davis OS 2009 The future of genetics in psychology and psychiatry: microarrays, genome-wide association, and non-coding RNA. J Child Psychol Psychiatry 50:63-71
9. Goh C, Agius M 2010 The stress-vulnerability model how does stress impact on mental illness at the level of the brain and what are the consequences? Psychiatr Danub 22:198-202
10. Kalueff AV, Wheaton M, Murphy DL 2007 What's wrong with my mouse model? Advances and strategies in animal modeling of anxiety and depression. Behav Brain Res 179:1-18 (Pubitemid 46441486)
11. Lister RG 1990 Ethologically-based animal models of anxiety disorders. Pharmacol Ther 46:321-340 (Pubitemid 20108519)
12. Belzung C, Griebel G 2001 Measuring normal and pathological anxiety-like behav-iour in mice: a review. Behav Brain Res 125:141-149 (Pubitemid 33000452)
13. Kendler KS, Myers J, Prescott CA 2002 The etiology of phobias: an evaluation of the stress-diathesis model. Arch Gen Psychiatry 59:242-248 (Pubitemid 34212501)
14. Walitza S, Wendland JR, Gruenblatt E, Warnke A, Sontag TA, Tucha O, Lange KW 2010 Genetics of early-onset obsessive-compulsive disorder. Eur Child Adolesc Psychiatry 19:227-235
15. Faraone SV, Mick E 2010 Molecular genetics of attention deficit hyperactivity disorder. Psychiatr Clin North Am 33:159-180
16. Maron E, Hettema JM, Shlik J 2010 Advances in molecular genetics of panic disorder. Mol Psychiatry 15:681-701
17. Ramboz S, Oosting R, Amara DA, Kung HF, Blier P, Mendelsohn M, Mann JJ, Brunner D, Hen R 1998 Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc Natl Acad Sci USA 95:14476-14481 (Pubitemid 28549392)
18. Holmes A, Lit Q, Murphy DL, Gold E, Crawley JN 2003 Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic back-ground. Genes Brain Behav 2:365-380 (Pubitemid 37463201)
19. Sodhi MS, Sanders-Bush E 2004 Serotonin and brain development. Int Rev Neurobiol 59:111-174 (Pubitemid 39752414)
20. Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Wein-berger DR 2005 A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry 62:146-152 (Pubitemid 40189130)
21. Lesch KP 2007 Linking emotion to the social brain. The role of the serotonin transporter in human social behaviour. EMBO Rep 8:S24-S29
22. Uher R, McGuffin P 2009 The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: update free. Mol Psychiatry 15:18-22, 2009
23. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE 2010 Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167:509-527
24. Nobile M, Rusconi M, Bellina M, Marino C, Giorda R, Carlet O, Vanzin L, Molteni M, Battaglia M 2009 The influence of family structure, the TPH2 G-703T and the 5-HTTLPR serotonergic genes upon affective problems in children aged 10-14 years. J Child Psychol Psychiatry 50:317-325
25. Holmes A, Murphy DL, Crawley JN 2003 Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol Psychiatry 54:953-959 (Pubitemid 37415031)
26. Holmes A, Yang RJ, Lesch KP, Crawley JN, Murphy DL 2003 Mice lacking the serotonin transporter exhibit 5-HT(1A) receptor-mediated abnormalities in tests for anxiety-like behavior. Neuropsychopharmacology 28:2077-2088 (Pubitemid 37468176)
27. Hendricks TJ, Fyodorov DV, Wegman LJ, Lelutiu NB, Pehek EA, Yamamoto B, Silver J, Weeber EJ, Sweatt JD, Deneris ES 2003 Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron 37:233-247 (Pubitemid 36143819)
28. Plomin R, Crabbe J DNA. Psychol Bull 126:806-828, 2000
29. Rutter ML 1996 Developmental psychopathology: concepts and prospects. In: Lenzenweger MF, Haugaard JJ (eds) Frontiers of Developmental Psychopathology. Oxford University Press, New York, pp 209-237
30. Nagy A 2000 Cre recombinase: the universal reagent for genome tailoring. Genesis 26:99-109 (Pubitemid 30158089)
31. Liu P, Jenkins NA, Copeland NG 2003 A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 13:476-484 (Pubitemid 36395405)
32. Jiang X, Xu K, Hoberman J, Tian F, Marko AJ, Waheed JF, Harris CR, Marini AM, Enoch MA, Lipsky RH 2005 BDNF variation and mood disorders: a novel func-tional promoter polymorphism and Val66Met are associated with anxiety but have opposing effects. Neuropsychopharmacology 30:1353-1361 (Pubitemid 40848089)
33. Lang UE, Hellweg R, Kalus P, Bajbouj M, Lenzen KP, Sander T, Kunz D, Gallinat J 2005 Association of a functional BDNF polymorphism and anxiety-related per-sonality traits. Psychopharmacology (Berl) 180:95-99 (Pubitemid 40897075)
34. Chen ZY, Jing D, Bath KG, Ieraci A, Khan T, Siao CJ, Herrera DG, Toth M, Yang C, McEwen BS, Hempstead BL, Lee FS 2006 Genetic variant BDNF (Val66Met) polymorphism alters anxiety-related behavior. Science 314:140-143 (Pubitemid 44547760)
35. Elzinga BM, Molendijk ML, Oude Voshaar RC, Bus BA, Prickaerts J, Spinhoven P, Penninx BJ 2011 The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val(66)Met. Psychopharmacology (Berl) 214:319-328
36. Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R 2004 Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet 36:1197-1202 (Pubitemid 41288969)
37. Leygraf A, Hohoff C, Freitag C, Willis-Owen SA, Krakowitzky P, Fritze J, Franke P, Bandelow B, Fimmers R, Flint J, Deckert J 2006 Rgs 2 gene polymorphisms as modulators of anxiety in humans? J Neural Transm 113:1921-1925 (Pubitemid 44749634)
38. Fullerton JM, Willis-Owen SA, Yalcin B, Shifman S, Copley RR, Miller SR, Bhomra A, Davidson S, Oliver PL, Mott R, Flint J 2008 Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus. Biol Psychiatry 63:874-883
39. Oliveira-Dos-Santos AJ, Matsumoto G, Snow BE 2000 Regulation of T cell activation, anxiety, and male aggression by RGS2. Proc Natl Acad Sci USA 97:12272-12277
40. Kendler KS, Greenspan RJ 2006 The nature of genetic influences on behavior: lessons from "simpler" organisms. Am J Psychiatry 163:1683-1694 (Pubitemid 44522473)
41. Flint J, Shifman S 2008 Animal models of psychiatric disease. Curr Opin Genet Dev 18:235-240
42. Kessler RC, Davis CG, Kendler KS 1997 Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey. Psychol Med 27:1101-1119 (Pubitemid 27401833)
43. McCutcheon VV, Heath AC, Nelson EC, Bucholz KK, Madden PA, Martin NG 2009 Accumulation of trauma over time and risk for depression in a twin sample. Psychol Med 39:431-441
44. Battaglia M, Pesenti-Gritti P, Medland SE, Ogliari A, Tambs K, Spatola CA 2009 A genetically informed study of the association between childhood separation anxiety, sensitivity to CO2, panic disorder, and the effect of childhood parental loss. Arch Gen Psychiatry 66:64-71
45. Hovens JG, Wiersma JE, Giltay EJ, van Oppen P, Spinhoven P, Penninx BW, Zitman FG 2010 Childhood life events and childhood trauma in adult patients with depressive, anxiety and comorbid disorders vs. controls. Acta Psychiatr Scand 122:66-74
46. Ogliari A, Tambs K, Harris JR, Scaini S, Maffei C, Reichborn-Kjennerud T, Battaglia M 2010 The relationships between adverse events, early antecedents, and carbon dioxide reactivity as an intermediate phenotype of panic disorder: a general population study. Psychother Psychosom 79:48-55
47. De Bellis MD, Kuchibhatla M 2006 Cerebellar volumes in pediatric maltreatment-related posttraumatic stress disorder. Biol Psychiatry 60:697-703 (Pubitemid 44427773)
48. Spinelli S, Chefer S, Suomi SJ, Higley JD, Barr CS, Stein E 2009 Early-life stress induces long-term morphologic changes in primate brain. Arch Gen Psychiatry 66:658-665
49. Shonkoff JP, Boyce WT, McEwen BS 2009 Neuroscience, molecular biology, and the childhood roots of health disparities: building a new framework for health promotion and disease prevention. JAMA 301:2252-2259
50. Levine S, Alpert M, Lewis GW 1957 Infantile experience and the maturation of the pituitary adrenal axis. Science 126:1347
51. Anisman H, Zaharia MD, Meaney MJ, Merali Z 1998 Do early-life events perma-nently alter behavioral and hormonal responses to stressors? Int J Dev Neurosci. 16:149-164 (Pubitemid 28427081)
52. Meaney MJ, Aitken DH, Bodnoff SR, Iny LJ, Sapolsky RM 1985 The effects of postnatal handling on the development of the glucocorticoid receptor systems and stress recovery in the rat Prog Neuropsychopharmacol Biol Psychiatry 9:731-734 (Pubitemid 16154173)
53. Plotsky PM, Meaney MJ 1993 Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Brain Res Mol Brain Res 18:195-200
54. McIntosh J, Anisman H, Merali Z 1999 Short-and long-periods ofneonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects. Brain Res Dev Brain Res 113:97-106 (Pubitemid 29125276)
55. Priebe K, Romeo RD, Francis DD, Sisti HM, Mueller A, McEwen BS, Brake WG 2006 Maternal influences on adult stress and anxiety-like behavior in C57BL/6J and BALB/cJ mice: a cross-fostering study. Dev Psychobiol 47:398-407; (Pubitemid 43081900)
56. Erratum in: Dev Psychobiol 48:95-96
57. Branchi I, D'Andrea I, Cirulli F, Lipp HP, Alleva E 2010 Shaping brain develop-ment: mouse communal nesting blunts adult neuroendocrine and behavioral response to social stress and modifies chronic antidepressant treatment outcome. Psychoneu-roendocrinology 35:743-751
58. D'Amato FR, Zanettini C, Sgobio C, Sarli C, Carone V, Moles A, Ammassari-Teule M 2010 Intensification of maternal care by double-mothering boosts cognitive function and hippocampal morphology in the adult offspring. Hippocampus 20:19-23
59. Li YQ, Wang XY, Zhai HF, Zheng YQ, Zhang XY, Kosten T, Lu L 2008 Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats. Psychopharmacology (Berl) 199:245-253
60. Mueller BR, Bale TL 2008 Sex-specific programming of offspring emotionality after stress early in pregnancy. J Neurosci 28:9055-9065
61. Lee JH, Kim HJ, Kim JG, Ryu V, Kim BT, Kang DW, Jahng JW 2007 Depressive behaviors and decreased expression of serotonin reuptake transporter in rats that experienced neonatal maternal separation. Neurosci Res 58:32-39 (Pubitemid 46678488)
62. Millstein RA, Holmes A 2007 Effects of repeated maternal separation on anxiety-and depression-related phenotypes in different mouse strains. Neurosci Biobehav Rev 31:3-17 (Pubitemid 44880075)
63. Moffett MC, Vicentic A, Kozel M, Plotsky P, Francis DD, Kuhar MJ 2007 Maternal separation alters drug intake patterns in adulthood in rats. Biochem Pharmacol 73:321-330 (Pubitemid 44958363)
64. D'Amato FR, Cabib S, Ventura R, Orsini C 1998 Long-term effects of postnatal manipulation on emotionality are prevented by maternal anxiolytic treatment in mice. Dev Psychobiol 32:225-234 (Pubitemid 28460234)
65. Stamatakis A, Pondiki S, Kitraki E, Diamantopoulou A, Panagiotaropoulos T, Raftogianni A, Stylianopoulou F 2008 Effect of neonatal handling on adult rat spatial learning and memory following acute stress. Stress 11:148-159 (Pubitemid 351323431)
66. Denenberg VH 1999 Commentary: is maternal stimulation the mediator of the handling effect in infancy? Dev Psychobiol 34:1-3 (Pubitemid 29025007)
67. Champagne FA, Francis DD, Mar A, Meaney MJ 2003 Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiol Behav 79:359-371 (Pubitemid 37098279)
68. Meaney MJ, Szyf M 2005 Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome. Dialogues Clin Neurosci 7:103-123 (Pubitemid 40961531)
69. Francis DD, Diorio J, Plotsky PM, Meaney MJ 2002 Environmental enrichment reverses the effects of maternal separation on stress reactivity. J Neurosci 22:7840-7843 (Pubitemid 35379088)
70. Laviola G, Hannan AJ, Macrì S, Solinas M, Jaber M 2008 Effects of enriched environment on animal models of neurodegenerative diseases and psychiatric dis-orders. Neurobiol Dis 31:159-168
71. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ 2004 Epigenetic programming by maternal behavior. Nat Neurosci 7:847-854 (Pubitemid 38989508)
72. Bandelow B, Alvarez Tichauer G, Späth C, Broocks A, Hajak G, Bleich S, Rüther E 2001 Separation anxiety and actual separation experiences during childhood in patients with panic disorder. Can J Psychiatry 46:948-952 (Pubitemid 34121558)
73. Gottesman II, Gould TD 2003 The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636-645 (Pubitemid 41079594)
74. Spatola CA, Scaini S, Pesenti-Gritti P, Medland SE, Moruzzi S, Ogliari A Thumbs C Battaglia M 2011 Gene-Environment Interactions in Panic Disorder and CO2 Sensitivity: Effects of Life Events Occurring Early in Life. Am J Med Genet B Neuropsychiatr Genet 156:79-88
75. Battaglia M, Ogliari A 2005 Anxiety and panic: from human studies to animal research and back. Neurosci Biobehav Rev 29:169-179 (Pubitemid 40094586)
76. Klein RG 1995 Is panic disorder associated with childhood separation anxiety disorder? Clin Neuropharmacol 18:S7-S14 (Pubitemid 26073110)
77. Battaglia M, Bertella S, Politi E, Bernardeschi L, Perna G, Gabriele A, Bellodi L 1995 Age at onset of panic disorder: influence of familial liability to the disease and of childhood separation anxiety disorder. Am J Psychiatry 152:1362-1364
78. Pine DS, Klein RG, Coplan JD, Papp LA, Hoven CW, Martinez J, Kovalenko P, Mandell DJ, Moreau D, Klein DF, Gorman JM 2000 Differential carbon dioxide sensitivity in childhood anxiety disorders and nonill comparison group. Arch Gen Psychiatry 57:960-967
79. Battaglia M, Pesenti-Gritti P, Spatola CA, Ogliari A, Tambs K 2008 A twin study of the common vulnerability between heightened sensitivity to hypercapnia and panic disorder. Am J Med Genet B Neuropsychiatr Genet 147B:586-593 (Pubitemid 351965478)
80. Genest SE, Gulemetova R, Laforest S, Drolet G, Kinkead R 2004 Neonatal maternal separation and sex-specific plasticity of the hypoxic ventilatory response in awake rat J Physiol 554:543-557 (Pubitemid 38181362)
81. Genest SE, Gulemetova R, Laforest S, Drolet G, Kinkead R 2007 Neonatal maternal separation induces sex-specific augmentation of the hypercapnic ventilatory re-sponse in awake rat J Appl Physiol 102:1416-1421 (Pubitemid 46571036)