A twin study of the common vulnerability between heightened sensitivity to hypercapnia and panic disorder

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 147, Issue 5, 2008, Pages 586-593

  Battaglia, Marco ^a,b,c   Pesenti Gritti, Paola ^a   Spatola, Chiara A M ^a   Ogliari, Anna ^a   Tambs, Kristian ^d  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SCIENTIFIC INSTITUTE   (Italy)

^c UNIVERSITÉ LAVAL   (Canada)

^d NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

Author keywords

Bivariate studies; Carbon dioxide; Covariation; Panic; Twin

Indexed keywords

ADULT; ANXIETY DISORDER; ARTICLE; CORRELATION ANALYSIS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE PREDISPOSITION; ENVIRONMENTAL FACTOR; FEMALE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HYPERCAPNIA; MAJOR CLINICAL STUDY; MALE; PANIC; PHENOTYPE; PRIORITY JOURNAL; SELF REPORT; TWINS;

ADULT; CARBON DIOXIDE; DISEASES IN TWINS; FEMALE; HUMANS; HYPERCAPNIA; MALE; MODELS, GENETIC; PANIC DISORDER; QUESTIONNAIRES; RANDOM ALLOCATION;

EID: 47049106163     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30647     Document Type: Article

References (46)

1. Akaike H. 1987. Factor analysis and AIC. Psychometrika 52:317-332.
2. Battaglia M, Ogliari A. 2005. Anxiety and panic: From human studies to animal research and back. Neurosci Biobehav Rev 29:169-179.
3. 2 challenge test in panic disorder: Optimization by receiver operating characteristics (ROC) analysis. J Psychiatr Res 29:111-119.
4. Battaglia M, Bertella S, Ogliari A, Bellodi L, Smeraldi E. 2001. Modulation by muscarinic antagonists of the response to carbon dioxide challenge in panic disorder. Arch Gen Psychiatry 58:114-119.
5. Battaglia M, Ogliari A, Harris J, Spatola CA, Pesenti-Gritti P, Reichborn-Kjennerud T, Torgersen S, Kringlen E, Tambs K. 2007. A genetic study of the acute anxious response to carbon dioxide stimulation in man. J Psychiatr Res 41:906-917.
6. 2 as a trait of familial panic disorder. Biol Psychiatry 49:582-587.
7. 2 inhalation in subjects at high-risk for panic disorder. J Affect Disord 92:63-70.
8. De Geus EJ, Boomsma DI. 2001. A genetic neuroscience approach to human cognition. Eur Psychologist 6:241-253.
9. Eley TC, Gregory AM, Clark DM, Ehlers A. 2007. Feeling anxious: A twin study of panic/somatic symptoms, anxiety sensitivity and heart-beat perception in children. J Child Psychol Psychiatry (in press).
10. Felsenfeld S, Kirk KM, Zhu G, Statham DJ, Neale MC, Martin NG. 2000. A study of the genetic and environmental etiology of stuttering in a selected twin sample. Behav Genet 30:359-366.
11. Fyer AJ, Weissman MM. 1999. Genetic linkage study of panic: Clinical methodology and description of pedigrees. Am J Med Genet 88:173-181.
12. Gregory AM, Rijsdijk FV, Dahl RE, McGuffin P, Eley TC. 2006. Associations between sleep problems, anxiety, and depression in twins at 8 years of age. Pediatrics 118:1124-1132.
13. Gregory AM, Caspi A, Moffit T, Koenen K, Eley TC, Poulton R. 2007. Juvenile mental health histories of adults with anxiety disorders. Am J Psychiatry 164:301-308.
14. Griez E, de Loof C, Pols H, Zandbergen J, Lousberg H. 1990a. Specific sensitivity of patients with panic attacks to carbon dioxide inhalation. Psychiatry Res 31:193-199.
15. 2 as a marker of severe anxiety in panic disorder. Am J Psychiatry 147:796-797.
16. Harris JR, Magnus P, Tambs K. 2002. The Norwegian Institute of Public Health Twin Panel: A description of the sample and program of research. Twin Res 5:415-423.
17. Harris JR, Magnus P, Tambs K. 2006. The Norwegian Institute of Public Health twin program of research: An update. Twin Res Hum Genet 9:858-864.
18. Jöreskog KG, Sörbom D. 1999. PRELIS 2.30. Chicago: Scientific Software International, Inc.
19. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. 1993. Panic disorder in women: A population-based twin study. Psychol Med 23: 397-406.
20. Kendler KS, Gardner CO, Prescott CA. 2001. Panic syndromes in a population-based sample of male and female twins. Psychol Med 31:989-1000.
21. Kendler KS, Myers J, Torgersen S, Neale MC, Reichborn-Kjennerud T. 2007. The heritability of cluster A personality disorders assessed by both personal interview and questionnaire. Psychol Med 37:655-665.
22. Klein DF. 1993. False suffocation alarms, spontaneous panic, and related conditions. Arch Gen Psychiatry 50:306-317.
23. Martin NG, Wilson SR. 1982. Bias in the estimation of heritability from truncated samples of twins. Behav Genet 12:467-472.
24. Meshorer E, Soreq H. 2006. Virtues and woes of AChE alternative splicingin stress-related neuropathologies. Trends Neurosci 29:216-224.
25. Neale MC, Cardon LR. 1992. Methodology for genetic studies of twins and families. Dordrecht, The Netherlands: Kluwer Academic Publishers BV.
26. Neale MC, Eaves LJ, Kendler KS, Hewitt JK. 1989. Bias in correlations from selected samples of relatives: The effects of soft selection. Behav Genet 19:163-169.
27. Neale MC, Boker SM, Xie G, Maes HH. 2003. Mx: Statistical modeling. 6th edition. Richmond: Dept of Psychiatry, Medical College of Virginia, Commonwealth University.
28. Olsson M, Annerbrink K, Bengtsson F, Hedner J, Eriksson E. 2004. Paroxetine influences respiration in rats: Implications for the treatment of panic disorder. Eur Neuropsychopharmacol 14:29-37.
29. Pfohl B, Blum N, Zimmerman M. 1997. The structured interview for DSM-IV personality disorders - SIDP-IV. Iowa City: The Iowa University.
30. Pine DS, Cohen P, Gurley D, Brook J, Ma Y. 1998. The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry 55:56-64.
31. Pols H, Zandbergen J, de Loof C, Griez E. 1991. Attenuation of carbon dioxide-induced panic after clonazepam treatment. Acta Psychiatr Scand 84:585-586.
32. Posthuma D, Boomsma DI. 2005. Mx scripts library: Structural equation modelling scripts for twin and family data. Behav Genet 35:499-505.
33. Rassovsky Y, Kushner MG. 2003. Carbon dioxide in the study of panic disorder: Issues of definition, methodology, and outcome. J Anxiety Disord 17:1-32.
34. Robins LN, Wing J, Wittchen HU, Heizer JE, Babor TF, Burke J, Farmer A, Jablenski A, Pickens R, Regier DA, et al. 1988. The composite international diagnostic interview. An epidemiological instrument suitable for use in conjunction with different diagnostic systems and in different cultures. Arch Gen Psychiatry 45:1069-1077.
35. Roy-Byrne PP, Cowley DS. 1998. Search for pathophysiology of panic disorder. Lancet 352:1646-1647.
36. Severson CA, Wang W, Pieribone VA, Dohle CI, Richerson GB. 2003. Midbrain serotonergic neurons are central pH chemoreceptors. Nat Neurosci 6:1139-1140.
37. Sinha SS, Goetz RR, Klein DF. 2007. Physiological and behavioral effects of naloxone and lactate in normal volunteers with relevance to the pathophysiology of panic disorder. Psychiatr Res 149:309-314.
38. Sklan EH, Lowenthal A, Korner M, Ritov Y, Landers DM, Rankinen T, Bouchard C, Leon AS, Rice T, Rao DC, et al. 2004. Acetylcholinesterase/ paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. Proc Natl Acad Sci USA 101:5512-5517.
39. Slutske WS, Eisen S, True WR, Lyons MJ, Goldberg J, Tsuang MT. 2000. Common genetic vulnerability for pathological gambling and alcohol dependence in men. Arch Gen Psychiatry 57:666-673.
40. Smoller JW, Tsuang MT. 1998. Panic and phobic anxiety: Defining phenotypes for genetic studies. Am J Psychiatry 155:1152-1162.
41. Stein MB, Jang KL, Livesley WJ. 1999. Heritability of anxiety sensitivity: A twin study. Am J Psychiatry 156:246-251.
42. Szatmari P, Maziade M, Zwaigenbaum L, Merette C, Roy M-A, Joober R, Palmour R. 2007. Informative phenotypes for genetic studies of psychiatric disorders. Am J Med Genet Part B 144B:581-588.
43. 2 challenge in healthy first-degree relatives of patients with panic disorder. Biol Psychiatry 47:830-835.
44. Verburg K, Pols H, de Leeuw M, Griez E. 1998. Reliability of the 35% carbon dioxide panic provocation challenge. Psychiatr Res 78:207-214.
45. Wade T, Neale MC, Lake RI, Martin NG. 1999. A genetic analysis of the eating and attitudes associated with bulimia nervosa: Dealing with the problem of ascertainment in twin studies. Behav Genet 29: 1-10.
46. Wolpe J. 1973. The practice of behavior therapy. Elmsford, NY: Pergamon Press, Inc.