11-Deoxycortisol impedes GABAergic neurotransmission and induces drug-resistant status epilepticus in mice

Neuropharmacology

Volumn 60, Issue 7-8, 2011, Pages 1098-1108

  Kaminski, Rafal M ^a   Fu, Zhanyan ^b   Venkatesan, Kumar ^c   Mazzuferi, Manuela ^a   Leclercq, Karine ^a   Seutin, Vincent ^c   Vicini, Stefano ^b  

^a UCB PHARMA   (Belgium)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

4 Aminopyridine; Cortisol; GABA; Hippocampus; Neurosteroids; Seizures

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CARBAMAZEPINE; CORTODOXONE; DIAZEPAM; ETIRACETAM; PHENYTOIN; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; DRUG MEGADOSE; EPILEPTIC STATE; GABAERGIC TRANSMISSION; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIAL; LOW DRUG DOSE; MALE; MOUSE; NERVE CELL CULTURE; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; SEIZURE; ANTICONVULSANT THERAPY; DISEASE ACTIVITY; DISEASE EXACERBATION; DISEASE MODEL; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; ELECTROENCEPHALOGRAM; EPILEPTIC DISCHARGE; NERVE CELL MEMBRANE POTENTIAL; NEUROPATHOLOGY; NEUROPROTECTION; TREATMENT OUTCOME;

ANIMALS; ANTICONVULSANTS; CEREBELLUM; CORTODOXONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; ELECTROENCEPHALOGRAPHY; EPILEPSY; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIALS; MALE; MICE; MICE, INBRED C57BL; PIRACETAM; RECEPTORS, GABA-A; STATUS EPILEPTICUS;

EID: 79954585122     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.09.021     Document Type: Article

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