The sphingosine kinase 1 and S1P1 axis specifically counteracts LPS-induced IL-12p70 production in immune cells of the spleen

Molecular Immunology

Volumn 48, Issue 9-10, 2011, Pages 1139-1148

  Schröder, Matthias ^a   Richter, Cornelia ^a,b   Juan, Martina Herrero San ^a   Maltusch, Katrin ^a   Giegold, Oliver ^a   Quintini, Gianluca ^d   Pfeilschifter, Josef M ^a   Huwiler, Andrea ^c   Radeke, Heinfried H ^a  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^c UNIVERSITY OF BERN   (Switzerland)

^d Nycomed GmbH   (Germany)

Author keywords

IL 12; S1P1; Sphingosine 1 phosphate; Sphingosine kinase 1; Spleen

Indexed keywords

5 (4 PHENYL 5 TRIFLUOROMETHYL 2 THIENYL) 3 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOLE; FLT3 LIGAND; INTERLEUKIN 12P70; LIPOPOLYSACCHARIDE; MESSENGER RNA; PERTUSSIS TOXIN; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE KINASE 1;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVITY; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN CELL; TH1 CELL; TH17 CELL; TH2 CELL;

ANIMALS; ANTIGENS, CD8; BONE MARROW CELLS; CELL DIFFERENTIATION; DENDRITIC CELLS; ENZYME ASSAYS; FLOW CYTOMETRY; GENE DELETION; GENE EXPRESSION REGULATION; INDANS; INTERLEUKIN-12; INTERLEUKIN-12 RECEPTOR BETA 2 SUBUNIT; INTERLEUKIN-12 SUBUNIT P40; LIPOPOLYSACCHARIDES; LYMPHOCYTE ACTIVATION; LYSOPHOSPHOLIPIDS; MEMBRANE PROTEINS; MICE; OXADIAZOLES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RNA, MESSENGER; SPHINGOSINE; SPLEEN; THIOPHENES; TOLL-LIKE RECEPTORS;

MUS;

EID: 79954571282     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2011.02.007     Document Type: Article

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