Epigenetic screening in product safety assessment: Are we there yet?

Toxicology Mechanisms and Methods

Volumn 21, Issue 4, 2011, Pages 298-311

  Rasoulpour, Reza J ^a   Lebaron, Matthew J ^a   Ellis Hutchings, Robert G ^a   Klapacz, Joanna ^a   Gollapudi, B Bhaskar ^a  

^a DOW CHEMICAL COMPANY   (United States)

Author keywords

chemical safety; Epigenetics; regulatory testing; risk assessment

Indexed keywords

5 METHYLCYTOSINE; ANDROGEN; ANDROSTENEDIONE; ANTIBODY; AROMATASE; AXIN; BISULFITE; CLASTOGEN; CYTOSINE; ENDOCRINE DISRUPTOR; ESTRADIOL; ESTROGEN RECEPTOR; ESTRONE; GREEN FLUORESCENT PROTEIN; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MICRORNA; OLIGOMER; RESTRICTION ENDONUCLEASE; TESTOSTERONE; THYMIDINE KINASE; UNTRANSLATED RNA; URACIL;

ACCESSORY SEX GLAND; AMES TEST; AMPHIBIAN METAMORPHOSIS ASSAY; ANEUPLOIDY; BACTERIAL MUTATION; BACTERIUM CULTURE; BINDING ASSAY; CELL ASSAY; CELL CYCLE ARREST; CELL DEATH; CELL SURVIVAL; CHROMATIN STRUCTURE; CHROMOSOME ABERRATION; CHROMOSOME ADDITION; CHROMOSOME ANALYSIS; CHROMOSOME BREAKAGE; CHROMOSOME DAMAGE; CHROMOSOME DELETION; CHROMOSOME SUBSTITUTION; CYTOSOL; CYTOTOXICITY; DEAMINATION; DNA DETERMINATION; DNA METHYLATION; DNA MODIFICATION; DNA SCREENING; DNA SEQUENCE; EMBRYONIC STEM CELL; ENDOCRINE DISRUPTOR SCREENING PROGRAM; ENZYME ACTIVITY; ENZYME INACTIVATION; EPA 21 DAY FISH REPRODUCTION ASSAY; EPIGENETICS; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GENE LOCUS; GENE MUTATION; GENETIC SCREENING; GENETIC TRANSCRIPTION; GENOME IMPRINTING; GENOTOXICITY; HERSHBERGER ASSAY; HETEROZYGOSITY; HISTONE MODIFICATION; HORMONE DETERMINATION; HORMONE INHIBITION; HORMONE RELEASE; HOUSEKEEPING GENE; IN VITRO STUDY; IN VIVO STUDY; LYMPHOMA; MAMMAL CELL; METAPHASE; MICROARRAY ANALYSIS; MICRONUCLEUS; MICRONUCLEUS TEST; MITOSIS SPINDLE; MUTAGENIC ACTIVITY; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEOSOME; NUCLEOTIDE SEQUENCE; ONCOGENE; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE; PRIORITY JOURNAL; PRODUCT SAFETY; PROTEOMICS; PUBERTAL ASSAY; PUBERTY; RETROPOSON; REVIEW; RISK ASSESSMENT; RNA ANALYSIS; SCREENING TEST; STEROIDOGENESIS; TOXICITY TESTING; TRANSACTIVATION; UTEROTROPHIC ASSAY; UTERUS; X CHROMOSOME; ZEBRA FISH;

ANIMAL TESTING ALTERNATIVES; ANIMALS; DNA METHYLATION; DRUG TOXICITY; ENDOCRINE DISRUPTORS; EPIGENESIS, GENETIC; GENETIC MARKERS; GENOMIC IMPRINTING; HISTONES; HUMANS; RISK ASSESSMENT; TOXICITY TESTS; TOXICOLOGY;

EID: 79954517922     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2011.557883     Document Type: Review

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