-
1
-
-
0028135079
-
Altering mice by homologous recombination using embryonic stem cells
-
Bronson SK, Smithies O, (1994) Altering mice by homologous recombination using embryonic stem cells. J Biol Chem 269: 27155-27158.
-
(1994)
J Biol Chem
, vol.269
, pp. 27155-27158
-
-
Bronson, S.K.1
Smithies, O.2
-
2
-
-
0017670013
-
Structural gene identification and making by DNA:mRNA hybrid-arrested cell-free translation
-
Paterson BM, Roberts BE, Kuff EL, (1977) Structural gene identification and making by DNA:mRNA hybrid-arrested cell-free translation. Proc Natl Acad Sci USA 74: 4370-4374.
-
(1977)
Proc Natl Acad Sci USA
, vol.74
, pp. 4370-4374
-
-
Paterson, B.M.1
Roberts, B.E.2
Kuff, E.L.3
-
3
-
-
0344363037
-
A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA)
-
Mizuno T, Chou MY, Inouye M, (1984) A unique mechanism regulating gene expression: translational inhibition by a complementary RNA transcript (micRNA). Proc Natl Acad Sci USA 81: 1966-1970.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 1966-1970
-
-
Mizuno, T.1
Chou, M.Y.2
Inouye, M.3
-
4
-
-
0021229867
-
Inhibition of thymidine kinase gene expression by anti-sense RNA: a molecular approach to genetic analysis
-
Izant JG, Weintraub H, (1984) Inhibition of thymidine kinase gene expression by anti-sense RNA: a molecular approach to genetic analysis. Cell 36: 1007-1015.
-
(1984)
Cell
, vol.36
, pp. 1007-1015
-
-
Izant, J.G.1
Weintraub, H.2
-
5
-
-
0026337408
-
Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes
-
Pieken WA, Olsen DB, Benseler F, Aurup H, Eckstein F, (1991) Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes. Science 253: 314-317.
-
(1991)
Science
, vol.253
, pp. 314-317
-
-
Pieken, W.A.1
Olsen, D.B.2
Benseler, F.3
Aurup, H.4
Eckstein, F.5
-
6
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, et al. (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391: 806-811.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
-
7
-
-
0032443021
-
Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
-
Kennerdell JR, Carthew RW, (1998) Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95: 1017-1026.
-
(1998)
Cell
, vol.95
, pp. 1017-1026
-
-
Kennerdell, J.R.1
Carthew, R.W.2
-
8
-
-
0041582974
-
Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
-
Zamecnik PC, Stephenson ML, (1978) Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc Nat Acad Sci USA 75: 280-288.
-
(1978)
Proc Nat Acad Sci USA
, vol.75
, pp. 280-288
-
-
Zamecnik, P.C.1
Stephenson, M.L.2
-
10
-
-
0032853334
-
Antisense oligonucleotides as therapeutic agents
-
Galderisi U, Cascino A, Giordano A, (1990) Antisense oligonucleotides as therapeutic agents. J Cell Physiol 181: 251-257.
-
(1990)
J Cell Physiol
, vol.181
, pp. 251-257
-
-
Galderisi, U.1
Cascino, A.2
Giordano, A.3
-
11
-
-
0031935087
-
Antisense oligonucleotide therapeutics for human leukemia
-
Gewirtz AM, (1998) Antisense oligonucleotide therapeutics for human leukemia. Curr Opin Hematol 5: 59-71.
-
(1998)
Curr Opin Hematol
, vol.5
, pp. 59-71
-
-
Gewirtz, A.M.1
-
12
-
-
0028815149
-
Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix
-
Guvakova MA, Yakubov LA, Vlodavsky I, Tonkinson JL, Stein CA, (1995) Phosphorothioate oligodeoxynucleotides bind to basic fibroblast growth factor, inhibit its binding to cell surface receptors, and remove it from low affinity binding sites on extracellular matrix. J Biol Chem 270: 2620-2627.
-
(1995)
J Biol Chem
, vol.270
, pp. 2620-2627
-
-
Guvakova, M.A.1
Yakubov, L.A.2
Vlodavsky, I.3
Tonkinson, J.L.4
Stein, C.A.5
-
13
-
-
0026573769
-
Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: implications for antisense technology
-
Gao WY, Han FS, Storm C, (1992) Phosphorothioate oligonucleotides are inhibitors of human DNA polymerases and RNase H: implications for antisense technology. Mol Pharmacol 41: 223-229.
-
(1992)
Mol Pharmacol
, vol.41
, pp. 223-229
-
-
Gao, W.Y.1
Han, F.S.2
Storm, C.3
-
14
-
-
0027364174
-
PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules
-
Egholm M, Buchardt O, Christensen L, Behrens C, Freier SM, et al. (1993) PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature 365: 566-568.
-
(1993)
Nature
, vol.365
, pp. 566-568
-
-
Egholm, M.1
Buchardt, O.2
Christensen, L.3
Behrens, C.4
Freier, S.M.5
-
15
-
-
0028675028
-
A DNA enzyme that cleaves RNA
-
Breaker RR, Joyce GF, (1994) A DNA enzyme that cleaves RNA. Chem Biol 1: 223-229.
-
(1994)
Chem Biol
, vol.1
, pp. 223-229
-
-
Breaker, R.R.1
Joyce, G.F.2
-
17
-
-
0034671699
-
Making catalytic DNAs
-
Breaker RR, (2000) Making catalytic DNAs. Science 290: 2095-2096.
-
(2000)
Science
, vol.290
, pp. 2095-2096
-
-
Breaker, R.R.1
-
18
-
-
0033832018
-
Catalytic nucleic acids: from lab to applications
-
Sun L-Q, Cairns MJ, Saravolac EG, (2000) Catalytic nucleic acids: from lab to applications. Pharmacol Rev 52: 325-347.
-
(2000)
Pharmacol Rev
, vol.52
, pp. 325-347
-
-
Sun, L.-Q.1
Cairns, M.J.2
Saravolac, E.G.3
-
19
-
-
77957362844
-
DNA as a versatile chemical component for catalysis, encoding, and stereocontrol
-
Silverman SK, (2010) DNA as a versatile chemical component for catalysis, encoding, and stereocontrol. Angew Chem Int Ed Engl 49: 7180-7201.
-
(2010)
Angew Chem Int Ed Engl
, vol.49
, pp. 7180-7201
-
-
Silverman, S.K.1
-
20
-
-
0032558463
-
Mechanism and utility of an RNA-cleaving DNA enzyme
-
Santoro SW, Joyce GF, (1998) Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry 37: 13330-13342.
-
(1998)
Biochemistry
, vol.37
, pp. 13330-13342
-
-
Santoro, S.W.1
Joyce, G.F.2
-
21
-
-
0036510780
-
Comparative study of DNA enzyme and ribozymes against the same full-length messenger RNA of the vanilloid receptor subtype I. J Biol
-
Kurreck J, Birgit B, Jahnel R, Erdmann VA, (2002) Comparative study of DNA enzyme and ribozymes against the same full-length messenger RNA of the vanilloid receptor subtype I. J Biol Chem 277: 7099-7107.
-
(2002)
Chem
, vol.277
, pp. 7099-7107
-
-
Kurreck, J.1
Birgit, B.2
Jahnel, R.3
Erdmann, V.A.4
-
22
-
-
0032912701
-
Target site selection for an RNA-cleaving catalytic DNA
-
Cairns MJ, Hopkins TM, Witherington C, Wang L, Sun L-Q, (1999) Target site selection for an RNA-cleaving catalytic DNA. Nat Biotechnol 17: 480-486.
-
(1999)
Nat Biotechnol
, vol.17
, pp. 480-486
-
-
Cairns, M.J.1
Hopkins, T.M.2
Witherington, C.3
Wang, L.4
Sun, L.-Q.5
-
24
-
-
0027419756
-
Peptide nucleic acids (PNAs): potential antisense and anti-gene agents
-
Nielsen PE, Egholm M, Berg RH, Burchardt O, (1993) Peptide nucleic acids (PNAs): potential antisense and anti-gene agents. Anticancer Drug Res 8: 53-63.
-
(1993)
Anticancer Drug Res
, vol.8
, pp. 53-63
-
-
Nielsen, P.E.1
Egholm, M.2
Berg, R.H.3
Burchardt, O.4
-
25
-
-
0032527839
-
Effects of helical structures formed by the binding arms of DNAzymes and their substrates on catalytic activity
-
Ota N, Warashina M, Hirano K, Hatanaka K, Taira K, (1998) Effects of helical structures formed by the binding arms of DNAzymes and their substrates on catalytic activity. Nucleic Acids Res 26: 3385-3391.
-
(1998)
Nucleic Acids Res
, vol.26
, pp. 3385-3391
-
-
Ota, N.1
Warashina, M.2
Hirano, K.3
Hatanaka, K.4
Taira, K.5
-
26
-
-
58749104364
-
The promises and pitfalls of RNA-interference-based therapeutics
-
Castanotto D, Rossi JJ, (2009) The promises and pitfalls of RNA-interference-based therapeutics. Nature 457: 426-4.
-
(2009)
Nature
, vol.457
, pp. 426-424
-
-
Castanotto, D.1
Rossi, J.J.2
-
27
-
-
77957820261
-
RNAi and small interfering RNAs in human disease therapeutic applications
-
Lares MR, Rossi JJ, Ouellet DL, (2010) RNAi and small interfering RNAs in human disease therapeutic applications. Trends Biotechnol 28: 570-579.
-
(2010)
Trends Biotechnol
, vol.28
, pp. 570-579
-
-
Lares, M.R.1
Rossi, J.J.2
Ouellet, D.L.3
-
28
-
-
78650624101
-
RNA interference in the clinic: challenges and future directions
-
Pecot CV, Calin GA, Coleman RL, Lopez-Berestein G, Sood AK, (2011) RNA interference in the clinic: challenges and future directions. Nat Rev Cancer 11: 59-67.
-
(2011)
Nat Rev Cancer
, vol.11
, pp. 59-67
-
-
Pecot, C.V.1
Calin, G.A.2
Coleman, R.L.3
Lopez-Berestein, G.4
Sood, A.K.5
-
30
-
-
77953635299
-
Biochemical principles of small RNA pathways
-
Liu Q, Paroo Z, (2010) Biochemical principles of small RNA pathways. Annu Rev Biochem 79: 295-319.
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 295-319
-
-
Liu, Q.1
Paroo, Z.2
-
31
-
-
11144330098
-
Natural and engineered nucleic acids as tools to explore biology
-
Breaker RR, (2004) Natural and engineered nucleic acids as tools to explore biology. Nature 432: 838-845.
-
(2004)
Nature
, vol.432
, pp. 838-845
-
-
Breaker, R.R.1
-
32
-
-
78651319695
-
Natural and engineered nicking endonucleases-from cleavage mechanism to engineering of strand-specificity
-
Chan SH, Stoddard BL, Xu SY, (2011) Natural and engineered nicking endonucleases-from cleavage mechanism to engineering of strand-specificity. Nucleic Acids Res 39: 1-18.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 1-18
-
-
Chan, S.H.1
Stoddard, B.L.2
Xu, S.Y.3
-
33
-
-
77950819888
-
Expanding the catalytic repertoire of ribozymes and deoxyribozymes beyond RNA substrates
-
Franzen S, (2010) Expanding the catalytic repertoire of ribozymes and deoxyribozymes beyond RNA substrates. Curr Opin Mol Ther 12: 223-232.
-
(2010)
Curr Opin Mol Ther
, vol.12
, pp. 223-232
-
-
Franzen, S.1
-
34
-
-
0036811085
-
Cellular uptake, distribution and stability of 10-23 deoxyribozymes
-
Dass CR, Saravolac EG, Li Y, Sun L-Q, (2002) Cellular uptake, distribution and stability of 10-23 deoxyribozymes. Antisense Nucleic Acid Drug Dev 12: 289-299.
-
(2002)
Antisense Nucleic Acid Drug Dev
, vol.12
, pp. 289-299
-
-
Dass, C.R.1
Saravolac, E.G.2
Li, Y.3
Sun, L.-Q.4
-
35
-
-
0344442416
-
RNA cleaving ''10-23'' DNAzymes with enhanced stability and activity
-
Schubert S, Gul DC, Grunert HP, Zeichhardt H, Erdmann VA, et al. (2003) RNA cleaving ''10-23'' DNAzymes with enhanced stability and activity. Nucleic Acids Res 31: 5982-5992.
-
(2003)
Nucleic Acids Res
, vol.31
, pp. 5982-5992
-
-
Schubert, S.1
Gul, D.C.2
Grunert, H.P.3
Zeichhardt, H.4
Erdmann, V.A.5
-
36
-
-
0029041941
-
The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis
-
Werner M, Uhlenbeck OC, (1995) The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis. Nucleic Acids Res 23: 2092-2096.
-
(1995)
Nucleic Acids Res
, vol.23
, pp. 2092-2096
-
-
Werner, M.1
Uhlenbeck, O.C.2
-
37
-
-
77954387386
-
A complex RNA-cleaving DNAzyme that can efficiently cleave a pyrimidine-pyrimidine junction
-
Lam JC, Withers JB, Li Y, (2010) A complex RNA-cleaving DNAzyme that can efficiently cleave a pyrimidine-pyrimidine junction. Journal of molecular biology 23;400 (4): 689-701.
-
(2010)
Journal of Molecular Biology 23
, vol.400
, Issue.4
, pp. 689-701
-
-
Lam, J.C.1
Withers, J.B.2
Li, Y.3
-
38
-
-
77957321136
-
Broad-spectrum and virus-specific nucleic acid-based antivirals against influenza
-
(Schol Ed)
-
Wong JP, Christopher ME, Salazar AM, Sun LQ, Viswanathan S, et al. (2010) Broad-spectrum and virus-specific nucleic acid-based antivirals against influenza. Front Biosci (Schol Ed) 2: 791-800.
-
(2010)
Front Biosci
, vol.2
, pp. 791-800
-
-
Wong, J.P.1
Christopher, M.E.2
Salazar, A.M.3
Sun, L.Q.4
Viswanathan, S.5
-
39
-
-
59649104166
-
DNAzyme-mediated catalysis with only guanosine and cytidine nucleotides
-
Schlosser K, Li Y, (2009) DNAzyme-mediated catalysis with only guanosine and cytidine nucleotides. Nucleic Acids Res 37 (2): 413-420.
-
(2009)
Nucleic Acids Res
, vol.37
, Issue.2
, pp. 413-420
-
-
Schlosser, K.1
Li, Y.2
-
40
-
-
77956107906
-
The application of ribozymes and DNAzymes in muscle and brain
-
Mastroyiannopoulos NP, Uney JB, Phylactou LA, (2010) The application of ribozymes and DNAzymes in muscle and brain. Molecules 15: 5460-5472.
-
(2010)
Molecules
, vol.15
, pp. 5460-5472
-
-
Mastroyiannopoulos, N.P.1
Uney, J.B.2
Phylactou, L.A.3
-
41
-
-
0027092897
-
Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides
-
Bennett CF, Chiang MY, Chan H, Shoemaker JE, Mirabelli CK, (1992) Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol Pharmacol 41: 1023-1033.
-
(1992)
Mol Pharmacol
, vol.41
, pp. 1023-1033
-
-
Bennett, C.F.1
Chiang, M.Y.2
Chan, H.3
Shoemaker, J.E.4
Mirabelli, C.K.5
-
42
-
-
10044261960
-
Ribozyme- and deoxyribozyme-strategies for medical applications
-
Schubert S, Kurreck J, (2004) Ribozyme- and deoxyribozyme-strategies for medical applications. Curr Drug Targets 5: 667-81.
-
(2004)
Curr Drug Targets
, vol.5
, pp. 667-681
-
-
Schubert, S.1
Kurreck, J.2
-
43
-
-
51849115599
-
The Use of 10-23 DNAzyme to Selectively Destroy the Allele of mRNA with a Unique Purine-Pyrimidine Dinucleotide
-
Tong-Hong Wang, Wan-Ting Li, Szu-Hsien Yu, Lo-Chun Au, (2008) The Use of 10-23 DNAzyme to Selectively Destroy the Allele of mRNA with a Unique Purine-Pyrimidine Dinucleotide. Oligonucleotides 18 (3): 295-300.
-
(2008)
Oligonucleotides
, vol.18
, Issue.3
, pp. 295-300
-
-
Tong-Hong, W.1
Wan-Ting, L.2
Szu-Hsien, Y.3
Lo-Chun, A.4
|