Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4 +CD25 +FoxP3 + regulatory T cells

British Journal of Pharmacology

Volumn 163, Issue 2, 2011, Pages 358-374

  Dutra, R C ^a   Cola, M ^a   Leite, D F P ^a   Bento, A F ^a   Claudino, R F ^a   Nascimento, A F Z ^a   Leal, P C ^a   Calixto, J B ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

CD4 +CD25 + T regulatory cells; cytokines; inflammatory bowel disease; matrix metalloproteinase 9; nuclear factor B; phosphoinositide 3 kinase ; trinitrobenzene sulphonic acid; vascular endothelial growth factor

Indexed keywords

5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; CD4 ANTIGEN; CXCL1 CHEMOKINE; DEXAMETHASONE; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; MYELOPEROXIDASE; TRANSCRIPTION FACTOR FOXP3; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CD4+ CD25+ FOXP3+ REGULATORY T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL STIMULATION; COLITIS; COLON INJURY; CONTROLLED STUDY; CYTOKINE RELEASE; DISTRIBUTION VOLUME; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; LAMINA PROPRIA; LYMPHOCYTE FUNCTION; MALE; MAXIMUM PLASMA CONCENTRATION; MEDIATOR RELEASE; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIGENS, CD4; APOPTOSIS; CELLS, CULTURED; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; COLITIS; COLON; CYTOKINES; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTESTINAL MUCOSA; MALE; MATRIX METALLOPROTEINASE 9; MICE; NEUTROPHIL INFILTRATION; NEUTROPHILS; NF-KAPPA B; QUINOXALINES; T-LYMPHOCYTES, REGULATORY; THIAZOLIDINEDIONES; TRINITROBENZENESULFONIC ACID; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79954479626     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01226.x     Document Type: Article

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