Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic

Journal of Virology

Volumn 70, Issue 3, 1996, Pages 1475-1480

  Nath, Avindra ^a,b   Psooy, Karen ^a   Martin, Carol ^a   Knudsen, Bodo ^a   Magnuson, David S K ^a   Haughey, Norman ^a   Geiger, Jonathan D ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; EPITOPE; EXCITATORY AMINO ACID RECEPTOR; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN SLICE; CALCIUM CELL LEVEL; CONTROLLED STUDY; FETUS; HIPPOCAMPUS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NERVE CELL EXCITABILITY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030068995     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.3.1475-1480.1996     Document Type: Article

References (42)

1. Akiyama, S. K., K. Nagata, and M. Yamada. 1990 Cell surface receptors for extracellular matrix components. Biochim. Biophys. Acta 1031:91-110.
2. Barillari, G., R. Gendelman, R. C. Gallo, and B. Ensoli. 1993. The Tat protein of human immunodeficiency virus, type 1, a growth factor for AIDS sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc. Natl. Acad. Sci USA 90:7941-7945.
3. Bayer, P., M. Kraft, A. Ejchart, M. Westendrop, R. Frank, and P. Rosch. 1995 Structural studies of HIV-1 Tat protein. J. Mol. Biol 247:529-535.
4. Ensolt, B., L. Buonaguro, G. Barillari, V. Fiorelli, R. Gendelman, R. A. Morgan, P. Wingfield, and R. C. Gallo. 1993 Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation J. Virol. 67:277-287.
5. Frankel, A., and C. O. Pabo. 1988. Cellular uptake of the Tat protein from human immunodeficiency virus Cell 55:1189-1193.
6. Furer, M., V. Hartloper, J. Wilkins, and A. Nath. Lymphocyte emperipolesis in human glial cells. Cell Adhes. Commun. 1:223-237.
7. Ghosh, A., and M. E. Greenberg. 1995. Calcium signaling in neurons: molecular mechanisms and cellular consequences. Science 268:239-247.
8. Giulian, D., E. Wendt, K. Vaca, and C. A. Coonan. 1993. The envelope glycoprotein of HIV-1 stimulates release of neurotoxins from monocytes. Proc. Natl. Acad. Sci. USA 90:2769-2773.
9. 2+ indicators with greatly improved fluorescence properties. J. Biol Chem. 260:3440-3450.
10. Harrison, M. J. G., and J. McArthur. 1995. HIV associated dementia complex, p. 31-64. In M J. G. Harrison and J. McArthur (ed.), AIDS and neurology Churchill Livingstone, New York.
11. Haughey, N., A. Nath, and J. D. Geiger. 1995. HIV-1 regulatory protein Tat and Tat fragments induced calcium in human brain cells Can. J. Inf. Dis. 6(Suppl. B):14.
12. Haughey, N., A. Nath, and J. D. Geiger. Unpublished observations.
13. Hayman, M., G. Arbuthnott, G. Harkiss, H. Brace, P. Filippi, V. Philippon, D. Thomson, R. Vigne, and A. Wright. 1993. Neurotoxicity of peptide analogues of the transactivating protein tat from maedi-visna virus and human immunodeficiency virus. Neuroscience 53:1-6.
14. Howcroft, T. K., K. Strebel, M. A. Martin, and D. S. Singer. 1993. Repression of MHC class I gene promoter activity by two-exon tat of HIV. Science 260:1320-1322
15. Janssen, E. S., O. C. Wanyanwu, R. M. Selik, and J. K. Stehr-Green. 1992. Epidemiology of human immunodeficiency encephalopathy in the United States. Neurology 42:1472-1476.
16. Jeypaul, J., M. R. Reddy, and S. A. Khan. 1990. Activity of synthetic Tat peptides in human immunodeficiency virus type 1 long terminal repeat-promoted transcription in a cell-free system. Proc. Natl Acad. Sci. USA 87:7030-7034.
17. Kolson, D. E., J. Buchhalter, R. Collman, B. Hellmig, C. F. Farrell, C. Debouk, and F. Gonzalez-Scrano. 1993. HIV-1 Tat alters normal organization of neurons and astrocytes in primary rodent brain cell cultures: RGD sequence dependence AIDS Res. Hum. Retroviruses 9:677-685
18. Koenig, S., H. Gendelman, J. M. Orenstein, M. C. Dal-Canto, G. H. Pezeshkpour, M. Yungbluth, F. Janotta, A. Aksamit, M. A. Martin, and A. S. Fauci. 1986. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233:1089-1093.
19. Kure, K., W. Lyman, K. Weidenheim, and D. Dickson. 1990. Cellular localization of HIV antigen in subacute AIDS encephalitis using an improved double labelling immunohistochemical method. Am. J. Pathol. 136:1085-1092
20. Lipton, S. A. 1993. Human immunodeficiency virus-infected macrophages, gp120, and N-methyl-D-aspartate receptor-mediated neurotoxicity. Ann. Neurol. 33:227-228.
21. Mabrouk, K., J. Van Rietschoten, E. Vives, H. Darbon, H. Rochat, and J.-M. Sabatier. 1991. Lethal neurotoxicity of the basic domains of HIV and SIV Rev proteins. FEBS Lett. 289:13-17.
22. Magnuson, D. S. K., B. E. Knudsen, J. D. Geiger, R. M. Brownstone, and A. Nath. 1995. Human immunodeficiency virus type 1 Tat activates non-N-methyl-D-aspartatc excitatory amino acid receptors and causes neurotoxicity. Ann. Neurol. 37:373-380.
23. McArthur, J. C., D. R. Hoover, H. Bacellar, E. N. Miller, B. A. Cohen, J. T. Becker, N. M. Graham, J. H. McArthur, O. A. Selnes, and L. P. Jacobson. 1993. Dementia in AIDS patients. Neurology 43:2245-2252.
24. Myers, G., B. Korber, S. Wain-Hobson, R. F. Smith, and G. N. Pavlakis. 1993. Human retroviruses and AIDS. Los Alamos National Laboratory, Los Alamos, N M.
25. Navia, B. A., E.-S. Cho, C. K. Petito, and R. W. Price. 1986. The AIDS dementia complex. II. Neuropathology. Ann Neurol. 19:525-535
26. Navia, B. A., and R. W. Price. 1987. The acquired immunodeficiency virus syndrome complex as the presenting sole manifestation of HIV infection. Arch Neurol. 44:65-69.
27. Parmentier, H. K., D. F. van Wichen, F. H. J. Gmelig-Meyling, J. Goudsmit, and H.-J. Schuurman. 1992. Epitopes of human immunodeficiency virus regulatory proteins tat, nef and rev are expressed in normal human tissue. Am J Pathol. 141:1209-1216.
28. 2+ permeable kainate/AMPA receptors more abundant in immature brain? Neurosci Lett 144:65-69.
29. Ranki, A., M. Nyberg, V. Ovod, M. Haltia, I. Elovaara, R. Rayninko, H. Haapasalo, and K. Krohn. 1995. Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS 9:1001-1008.
30. Sabatier, J.-M., E. Vives, K. Mabrouk, A. Benjouad, H. Rochat, A. Duval, B. Hue, and E. Bahraoui. 1991 Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1. J. Virol. 65:961-967
31. Saito, Y., L. Sharer, L. Epstein, J. Michaels, M. Mintz, M. Louder, K. Goulding, T. A. Cvetkovich, and B. M. Blumberg. 1994. Overexpression of Nef as a marker for restricted HIV-1 infection of astrocytes in postmortem pediatric central nervous system tissues. Neurology 44:474-481.
32. Sharer, L. R. 1992 Pathology of HIV-1 infection of the central nervous system. A review J. Neuropathol. Exp. Neurol. 51:3-11.
33. Sticht, H., D. Willbold, P. Bayer, A. Ejchart, F. Herman, R. Rosin-Arbesfeld, A. Gazit, A. Yaniv, R. Frank, and P. Rosch. 1993. Equine infectious anemia virus Tat is a predominantly helical protein. Eur. J. Biochem. 218:973-976.
34. Tardieu, M., C. Hery, S. Peudenier, O. Boespflug, and L. Montagnier. 1992 Human immunodeficiency virus type 1-infected cells can destroy human neural cells after cell-to-cell adhesion. Ann Neurol. 32:11-17.
35. Tornatore, C., R. Chandra, J. Berger, and E. O. Major. 1994. HIV infection of subcortical astrocytes in the pediatric central nervous system Neurology 44:481-487.
36. Vazeux, R., C. Lacroix-Ciarudo, S. Blanche, M.-C. Crumont, D. Henin, F. Gray, L. Boccon-Gibod, and M. Tardieu. 1992 Low levels of human immunodeficiency virus replication in the brain tissue of children with severe acquired immunodeficiency syndrome encephalopathy. Am. J. Pathol. 140: 137-144.
37. Visidi, R., K. Mayur, H. Lederman, and A. Frenkel. 1989. Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1 Sci-ence 246:1606-1608.
38. 5, integrin to the basic domain of the HIV Tat protein and vitronectin. J Cell Biol. 121:461-468.
39. Weeks, B. S., K. Desai, P. M. Loewenstein, M. E. Klotman, P. E. Klotman, M. Green, and H. K. Kleinman. 1993. Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein. J. Biol. Chem. 268:5279-5284.
40. Weeks, B. S., D. M. Lieberman, B. Johnson, E. Roque, M. Green, P. Lowenstein, E. H. Oldfield, and H. K. Kleinman. 1995. Neurotoxicity of the human immunodeficiency virus type 1 Tat transactivator to PC12 cells requires the Tat amino acid 49-58 basic domain. J. Neurosci. Res. 42:34-40.
41. Werner, T., S. Ferroni, T. Saermark, R. Brack-Werner, R. B. Banati, R. Mager, L. Steinaa, G. W. Kreutzberg, and V. Erfle. 1991 HIV-1 Nef protein exhibits structural and functional similarity to scorpion peptides interacting with potassium channels. AIDS 5:1301-1308.
42. Wiley, C., R. Shirer, J. Nelson, P. Lampert, and M. Oldstone. 1986. Cellular localization of human immunodeficiency virus infection within the brains of acquired immunodeficiency syndrome patients. Proc. Natl. Acad. Sci USA 83:7089-7093.