CITED2 is activated in ulcerative colitis and induces p53-dependent apoptosis in response to butyric acid

Journal of Gastroenterology

Volumn 46, Issue 3, 2011, Pages 339-349

  Yoshida, Tsutomu ^a   Sekine, Tsukasa ^a   Aisaki, Ken Ichi ^b   Mikami, Tetuo ^a   Kanno, Jun ^b   Okayasu, Isao ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Apoptosis; Butyric acid; CBP p300; CITED2; Inflammation; p53; Ulcerative colitis

Indexed keywords

BUTYRIC ACID; COMPLEMENTARY DNA; HISTONE ACETYLTRANSFERASE PCAF; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 1; PROTEIN CITED2; PROTEIN P300; PROTEIN P53; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ACETYLATION; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; COLON MUCOSA; CONTROLLED STUDY; DOWN REGULATION; FUSOBACTERIUM VARIUM; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH EROSION; TRANSCRIPTION REGULATION; ULCERATIVE COLITIS; UPREGULATION;

APOPTOSIS; BUTYRIC ACID; CELL LINE, TUMOR; COLITIS, ULCERATIVE; COLON; GENES, P53; HUMANS; INTESTINAL MUCOSA; REPRESSOR PROTEINS; RNA, MESSENGER; TRANS-ACTIVATORS; UP-REGULATION;

EID: 79954417473     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0355-9     Document Type: Article

References (41)

1. N Arai H Mitomi Y Ohtani M Igarashi A Kakita I Okayasu 1999 Enhanced epithelial cell turnover associated with p53 accumulation and high p21WAF1/CIP1 expression in ulcerative colitis Mod Pathol 12 604 611 10392637 1:STN:280:DyaK1MzhvFyjug%3D%3D (Pubitemid 29279714)
2. J Mitsuhashi T Mikami K Saigenji I Okayasu 2005 Significant correlation of morphological remodeling in ulcerative colitis with disease duration and between elevated p53 and p21 expression in rectal mucosa and neoplastic development Pathol Int 55 113 121 15743319 10.1111/j.1440-1827.2005.01802.x (Pubitemid 40477222)
3. I Okayasu S Hatakeyama M Yamada T Ohkusa Y Inagaki R Nakaya 1990 A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice Gastroenterology 98 694 702 1688816 1:STN:280: DyaK3c7ivVSnuw%3D%3D (Pubitemid 20069706)
4. I Okayasu T Ohkusa K Kajiura J Kanno S Sakamoto 1996 Promotion of colorectal neoplasia in experimental murine ulcerative colitis Gut 39 87 92 8881816 10.1136/gut.39.1.87 1:STN:280:DyaK2s%2Fjs1Wlug%3D%3D (Pubitemid 26239112)
5. I Okayasu M Yamada T Mikami T Yoshida J Kanno T Ohkusa 2002 Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model J Gastroenterol Hepatol 17 1078 1083 12201867 10.1046/j.1440-1746.2002. 02853.x (Pubitemid 35013962)
6. R Kuhn J Lohler D Rennick K Rajewsky W Muller 1993 Interleukin-10- deficient mice develop chronic enterocolitis Cell 75 263 274 8402911 10.1016/0092-8674(93)80068-P 1:STN:280:DyaK2c%2Fgs1Gmug%3D%3D (Pubitemid 23320290)
7. RK Sellon S Tonkonogy M Schultz LA Dieleman W Grenther E Balish, et al. 1998 Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice Infect Immun 66 5224 5231 9784526 1:CAS:528:DyaK1cXntFWmsLk%3D (Pubitemid 29044613)
8. A Shkoda PA Ruiz H Daniel SC Kim G Rogler RB Sartor, et al. 2007 Interleukin-10 blocked endoplasmic reticulum stress in intestinal epithelial cells: impact on chronic inflammation Gastroenterology 132 190 207 17241871 10.1053/j.gastro.2006.10.030 1:CAS:528:DC%2BD2sXit1aqsb0%3D (Pubitemid 46108743)
9. T Ohkusa N Sato T Ogihara K Morita M Ogawa I Okayasu 2002 Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody J Gastroenterol Hepatol 17 849 853 12164960 10.1046/j.1440-1746.2002.02834.x
10. T Ohkusa T Yoshida N Sato S Watanabe H Tajiri I Okayasu 2009 Commensal bacteria can enter colonic epithelial cells and induce proinflammatory cytokine secretion: a possible pathogenic mechanism of ulcerative colitis J Med Microbiol 58 535 545 19369513 10.1099/jmm.0.005801-0 1:CAS:528:DC%2BD1MXmt1Wks7w%3D
11. T Ohkusa I Okayasu T Ogihara K Morita M Ogawa N Sato 2003 Induction of experimental ulcerative colitis by Fusobacterium varium isolated from colonic mucosa of patients with ulcerative colitis Gut 52 79 83 12477765 10.1136/gut.52.1.79 1:STN:280:DC%2BD3s%2FgsVCluw%3D%3D (Pubitemid 36020770)
12. T Yoshida S Haga Y Numata K Yamashita T Mikami T Ogawa, et al. 2006 Disruption of the p53-p53r2 DNA repair system in ulcerative colitis contributes to colon tumorigenesis Int J Cancer 118 1395 1403 16206288 10.1002/ijc.21538 1:CAS:528:DC%2BD28XhslCqsrg%3D
13. T Ohkusa T Nomura T Terai H Miwa O Kobayashi M Hojo, et al. 2005 Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: a randomized, controlled pilot trial with long-term follow-up Scand J Gastroenterol 40 1334 1342 16334443 10.1080/00365520510023648 1:CAS:528:DC%2BD2MXhtFCjtrnK (Pubitemid 41658733)
14. T Nomura T Ohkusa I Okayasu T Yoshida M Sakamoto H Hayashi, et al. 2005 Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy Aliment Pharmacol Ther 21 1017 1027 15813838 10.1111/j.1365-2036.2005.02428.x 1:CAS:528:DC%2BD2MXktlegur4%3D (Pubitemid 40529736)
15. Ohkusa T, Kato K, Terao S, Chiba T, Mabe K, Murakami K, et al. Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial. Am J Gastroenterol. 2010;105:1820-9.
16. K Yamashita S Yasuda T Kuba Y Otani M Fujiwara I Okayasu 2004 Unique characteristics of rectal carcinoma cell lines derived from invasive carcinomas in ulcerative colitis patients Cancer Sci 95 211 217 15016319 10.1111/j.1349-7006.2004.tb02205.x 1:CAS:528:DC%2BD2cXjs1ymurs%3D (Pubitemid 38489086)
17. Kanno J, Aisaki K, Igarashi K, Nakatsu N, Ono A, Kodama Y, et al. "Per cell" normalization method for mRNA measurement by quantitative PCR and microarrays. BMC Genomics. 2006;7:64.
18. MK Leung T Jones CL Michels DM Livingston S Bhattacharya 1999 Molecular cloning and chromosomal localization of the human CITED2 gene encoding p35srj/Mrg1 Genomics 61 307 313 10552932 10.1006/geno.1999.5970 1:CAS:528:DyaK1MXntFWqsL0%3D
19. T Sanosaka M Namihira H Asano J Kohyama K Aisaki K Igarashi, et al. 2008 Identification of genes that restrict astrocyte differentiation of midgestational neural precursor cells Neuroscience 155 780 788 18640244 10.1016/j.neuroscience.2008.06.039 1:CAS:528:DC%2BD1cXhtVSgtbbK
20. K Aisaki S Aizawa H Fujii J Kanno H Kanno 2007 Glycolytic inhibition by mutation of pyruvate kinase gene increases oxidative stress and causes apoptosis of a pyruvate kinase deficient cell line Exp Hematol 35 1190 1200 17662887 10.1016/j.exphem.2007.05.005 1:CAS:528:DC%2BD2sXotlShur8%3D (Pubitemid 47088780)
21. SG Matts 1961 The value of rectal biopsy in the diagnosis of ulcerative colitis Q J Med 30 393 407 14471445 1:STN:280:DyaF38%2Fnt12iug%3D%3D
22. FA Sinicrope M Lemoine L Xi PM Lynch KR Cleary Y Shen, et al. 1999 Reduced expression of cyclooxygenase 2 proteins in hereditary nonpolyposis colorectal cancers relative to sporadic cancers Gastroenterology 117 350 358 10419916 10.1053/gast.1999.0029900350 1:CAS:528:DyaK1MXltFKqtr8%3D (Pubitemid 29352943)
23. J Braganca JJ Eloranta SD Bamforth JC Ibbitt HC Hurst S Bhattacharya 2003 Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2 J Biol Chem 278 16021 16029 12586840 10.1074/jbc.M208144200 1:CAS:528:DC%2BD3sXjt1ehsbk%3D (Pubitemid 36799722)
24. JP Kruse W Gu 2009 Modes of p53 regulation Cell 137 609 622 19450511 10.1016/j.cell.2009.04.050 1:CAS:528:DC%2BD1MXosVCltrs%3D
25. SW Lowe HE Ruley T Jacks DE Housman 1993 p53-dependent apoptosis modulates the cytotoxicity of anticancer agents Cell 74 957 967 8402885 10.1016/0092-8674(93)90719-7 1:CAS:528:DyaK3sXlvFGhtLk%3D (Pubitemid 23289454)
26. KH Vousden C Prives 2009 Blinded by the light: the growing complexity of p53 Cell 137 413 431 19410540 10.1016/j.cell.2009.04.037 1:CAS:528: DC%2BD1MXlvFams74%3D
27. T Yoshida T Mikami H Mitomi I Okayasu 2003 Diverse p53 alterations in ulcerative colitis-associated low-grade dysplasia: full-length gene sequencing in microdissected single crypts J Pathol 199 166 175 12533829 10.1002/path.1264 1:CAS:528:DC%2BD3sXhs1ygu7c%3D (Pubitemid 36176022)
28. W Scheppach 1994 Effects of short chain fatty acids on gut morphology and function Gut 35 S35 S38 8125387 10.1136/gut.35.1-Suppl.S35 1:CAS:528: DyaK2cXjt1Wru7Y%3D
29. S Sperling CH Grimm I Dunkel S Mebus HP Sperling A Ebner, et al. 2005 Identification and functional analysis of CITED2 mutations in patients with congenital heart defects Hum Mutat 26 575 582 16287139 10.1002/humu.20262 1:CAS:528:DC%2BD28Xjs1CqtQ%3D%3D (Pubitemid 41780480)
30. X Qu E Lam YQ Doughman Y Chen YT Chou M Lam, et al. 2007 Cited2, a coactivator of HNF4alpha, is essential for liver development EMBO J 26 4445 4456 17932483 10.1038/sj.emboj.7601883 1:CAS:528:DC%2BD2sXht1emtbvP (Pubitemid 350036639)
31. S Bhattacharya CL Michels MK Leung ZP Arany AL Kung DM Livingston 1999 Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1 Genes Dev 13 64 75 9887100 10.1101/gad.13.1.64 1:CAS:528:DyaK1MXnvF2rtw%3D%3D (Pubitemid 29045116)
32. WJ Bakker IS Harris TW Mak 2007 FOXO3a is activated in response to hypoxic stress and inhibits HIF1-induced apoptosis via regulation of CITED2 Mol Cell 28 941 953 18158893 10.1016/j.molcel.2007.10.035 1:CAS:528: DC%2BD1cXksFyjug%3D%3D (Pubitemid 350297029)
33. H Suzuki A Tomida T Tsuruo 2001 Dephosphorylated hypoxia-inducible factor 1alpha as a mediator of p53-dependent apoptosis during hypoxia Oncogene 20 5779 5788 11593383 10.1038/sj.onc.1204742 1:CAS:528:DC%2BD3MXntlSgtr0%3D (Pubitemid 32937947)
34. AL Harris 2002 Hypoxia-a key regulatory factor in tumour growth Nat Rev Cancer 2 38 47 11902584 10.1038/nrc704 1:CAS:528:DC%2BD38XhvF2jtL4%3D (Pubitemid 37328806)
35. AE Greijer E van der Wall 2004 The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis J Clin Pathol 57 1009 1014 15452150 10.1136/jcp.2003.015032 1:CAS:528:DC%2BD2cXps1Kls78%3D (Pubitemid 39331346)
36. HM Sowter PJ Ratcliffe P Watson AH Greenberg AL Harris 2001 HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors Cancer Res 61 6669 6673 11559532 1:CAS:528: DC%2BD3MXntFaisrc%3D (Pubitemid 32896483)
37. CK Garcia X Li J Luna U Francke 1994 cDNA cloning of the human monocarboxylate transporter 1 and chromosomal localization of the SLC16A1 locus to 1p13.2-p12 Genomics 23 500 503 7835905 10.1006/geno.1994.1532 1:CAS:528:DyaK2MXhtFOisrY%3D (Pubitemid 24308277)
38. M Cuff J Dyer M Jones S Shirazi-Beechey 2005 The human colonic monocarboxylate transporter Isoform 1: its potential importance to colonic tissue homeostasis Gastroenterology 128 676 686 15765403 10.1053/j.gastro.2004. 12.003 1:CAS:528:DC%2BD2MXivFWntLs%3D (Pubitemid 40585370)
39. W Gu RG Roeder 1997 Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain Cell 90 595 606 9288740 10.1016/S0092-8674(00)80521-8 1:CAS:528:DyaK2sXlvFKmtLc%3D (Pubitemid 27357952)
40. T Yoshida N Matsumoto T Mikami I Okayasu 2004 Upregulation of p16(INK4A) and Bax in p53 wild/p53-overexpressing crypts in ulcerative colitis-associated tumours Br J Cancer 91 1081 1088 15292938 1:CAS:528:DC%2BD2cXot1CksLk%3D (Pubitemid 39336246)
41. T Ohkusa I Okayasu S Tokoi Y Ozaki 1993 Bacterial invasion into the colonic mucosa in ulcerative colitis J Gastroenterol Hepatol 8 116 118 8439657 10.1111/j.1440-1746.1993.tb01184.x 1:STN:280:DyaK3s7ns12lsA%3D%3D (Pubitemid 23092151)