Glycolytic inhibition by mutation of pyruvate kinase gene increases oxidative stress and causes apoptosis of a pyruvate kinase deficient cell line

Experimental Hematology

Volumn 35, Issue 8, 2007, Pages 1190-1200

  Aisaki, Ken ichi ^a   Aizawa, Shin ^b   Fujii, Hisaichi ^c   Kanno, Jun ^a   Kanno, Hitoshi ^c,d  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; DEOXYGLUCOSE; DICHLORODIHYDROFLUORESCEIN DIACETATE; GENE PRODUCT; GLUTAREDOXIN; GLUTATHIONE; HYPOXIA INDUCIBLE FACTOR 1; LIPOCORTIN 5; PEROXIREDOXIN; PROTEIN BAD; PROTEIN BNIP3; PROTEIN BNIP31; PYRUVATE KINASE; REACTIVE OXYGEN METABOLITE; THIOREDOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ASSAY; ENZYME DEFICIENCY; ERYTHROLEUKEMIA CELL; FLOW CYTOMETRY; FLUORESCENCE; GENE MUTATION; GENETIC TRANSFECTION; GLYCOLYSIS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE;

ANIMALS; APOPTOSIS; CELL LINE; CELL LINE, TUMOR; ERYTHROCYTES; FLOW CYTOMETRY; GENETIC PREDISPOSITION TO DISEASE; GLYCOLYSIS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PYRUVATE KINASE;

EID: 34447651120     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2007.05.005     Document Type: Article

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