Tetramethylpyrazine inhibits hypoxia-induced pulmonary vascular leakage in rats via the ROS-HIF-VEGF pathway

Pharmacology

Volumn 87, Issue 5-6, 2011, Pages 265-273

  Zhang, Le ^a   Deng, Mengyang ^a   Zhou, Shiwen ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hypoxia; Hypoxia inducible factor 1 ; Pulmonary vascular leakage; Reactive oxygen species; Tetramethylpyrazine; Vascular endothelial growth factor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; REACTIVE OXYGEN METABOLITE; TETRAMETHYLPYRAZINE; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PERMEABILIZATION; CONTROLLED STUDY; DOWN REGULATION; HYPOBARISM; HYPOXIA; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PULMONARY VASCULAR DISEASE; PULMONARY VASCULAR LEAKAGE; RAT;

ANIMALS; CAPILLARY PERMEABILITY; CELL HYPOXIA; CELLS, CULTURED; ENDOTHELIAL CELLS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG; MALE; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 79953903076     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000326082     Document Type: Article

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