Ginkgo biloba extract prevents high altitude pulmonary edema in rats

High Altitude Medicine and Biology

Volumn 5, Issue 4, 2004, Pages 429-434

  Berg, John T ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

Alternative medicine; Altitude sickness; Bronchoalveolar lavage; Hypoxia; Lung injury; Protein

Indexed keywords

GINKGO BILOBA EXTRACT; GINKOBA; PHARMATHON; PLASMA PROTEIN; WATER;

ACUTE DISEASE; ALTITUDE DISEASE; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DISEASE SEVERITY; DRY WEIGHT; HYPOXIA; LUNG EDEMA; LUNG INJURY; LUNG LAVAGE; LUNG WEIGHT; MALE; NONHUMAN; PLEURA EFFUSION; PLEURA FLUID; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SEA LEVEL; STANDARDIZATION;

ALTITUDE; ALTITUDE SICKNESS; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; GINKGO BILOBA; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PULMONARY EDEMA; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS;

EID: 14644425330     PISSN: 15270297     EISSN: None     Source Type: Journal    
DOI: 10.1089/ham.2004.5.429     Document Type: Article

References (20)

1. Berg J.T., Breen E.C., Fu Z, Mathieu-Costello O, and West J.B. (1998). Alveolar hypoxia increases gene expression of extracellular matrix proteins and platelet-derived growth factor-B in lung parenchyma. Am. J. Respir. Crit. Care Med. 158:1920-1928.
2. Berg J.T., Ramanathan S., and Swenson E.R. (2004). Inhibitors of hypoxic pulmonary vasoconstriction prevent HAPE in rats. Wilderness Environ. Med. 15:32-37.
3. Carpenter T.C., Reeves J.T., and Durmowicz A.G. (1998). Viral respiratory infection increases susceptibility of young rats to hypoxia-induced pulmonary edema. J. Appl. Physiol. 84(3):1048-1054.
4. Cheng D., Chen W., Yang X., Xiao X, and Xu D. (1996). Effects of ginkgo plus on hypoxic pulmonary hypertension in rats. Hua Xi Yi Ke Da Xue Bao. 27(4):415-417.
5. Fujita Y., Mori I., and Kitano S. (1983). Color reaction between pyrogallol red-molybdenum (VI) complex and protein. Bunseki Kagaku. 32:E379-386.
6. Gertsch J.H., Seto T.B., Mor J., and Onopa J. (2002). Ginkgo biloba for the prevention of severe acute mountain sickness (AMS) starting one day before rapid ascent. High Alt. Med. Biol. 3(1):29-37.
7. Gertsch J.H., Basnyat B., Johnson E.W., Onopa J., and Holck P.S. (2004). Randomised, double blind, placebo controlled comparison of G. biloba and acetazolamide for prevention of acute mountain sickness among Himalayan trekkers: the prevention of high altitude illness trial (PHATT). BMJ. Doi: 10.1136/bmj.38043. 501690.7C (published 11 March 2004).
8. Hultrgen H.N., Lopez C.E., Lundberg E., and Miller H. (1965). Physiologic studies of pulmonary edema at high altitude. Circulation 29:393-408.
9. Janssens D., Michiels C., Delaive E., Eliaers F., Drieu K., and Remacle J. (1995). Protection of hypoxia-induced ATP decrease in endothelial cells by Ginkgo biloba extract and bilobalide. Biochem. Pharmacol. 50(7):991-999.
10. Leadbetter G., Maakestad K., Olson S., and Hackett P.H. (2001). Ginkgo biloba reduces incidence and severity of acute mountain sickness. High Alt. Med. Biol. 2(1):110.
11. Louajri A., Harraga S., Godot V., Toubin G., Kantelip J.P., and Magnin P. (2001). The effect of Ginkgo biloba extract on free radical production in hypoxic rats. Biol. Pharm. Bull. 24(6):710-712.
12. Maggiorini M. (2003). Cardio-pulmonary interactions at high altitude. Pulmonary hypertension as a common denominator. Adv. Exp. Med. Biol. 543:177-189.
13. Mahady G.B. (2002). Ginkgo biloba for the prevention and treatment of cardiovascular disease: a review of the literature. J. Cardiovasc. Nurs. 16(4):21-32.
14. Omura A., Roy R., and Jennings T. (2000). Inhaled nitric oxide improves survival in the rat model of high-altitude pulmonary edema. Wilderness Environ. Med. 11:251-256.
15. Ono S., Westcott J.Y., Chang S.-W., and Voelkel N.F. (1993). Endotoxin priming followed by high altitude causes pulmonary edema in rats. J. Appl. Physiol. 74(4): 1534-1542.
16. Pittler M.H., and Ernst E. (2000). Ginkgo biloba extract for the treatment of intermittent claudication: a meta-analysis of randomized trials. Am. J. Med. 108:276-281.
17. Roncin J.P., Schwartz F., and D'Arbigny P. (1996). EGb 761 in control of acute mountain sickness and vascular reactivity to cold exposure. Aviat. Space Environ. Med. 67(5):445-452.
18. Smith R.M. (1988). Pulmonary oxygen toxicity in rats: Prevention by pyrogenic diphosphoryl lipid A and potentiation by nontoxic monophosphoryl lipid A and lipid X. Res. Commun. Chem. Pathol. Pharmacol. 62:221-234.
19. Stalzner T.J., O'Brien R.F., Sato K., and Weil J.V. (1988). Hypoxia-induced increases in pulmonary transvascular protein escape in rats. J. Clin. Invest. 82:1840-1847.
20. Yang H., Xu Y., and Zhang Z. (2000). The effect of Ginkgo biloba on hypoxic pulmonary hypertension and the role of protein kinase C. Zhonghua Jie He He Hu Xi Za Zhi. 23(10):602-605.