Mechanism of action and structural requirements of constrained peptide inhibitors of RGS proteins

Chemical Biology and Drug Design

Volumn 67, Issue 4, 2006, Pages 266-274

  Roof, Rebecca A ^a   Jin, Yafei ^b   Roman, David L ^a   Sunahara, Roger K ^a   Ishii, Masaru ^c   Mosberg, Henry I ^b   Neubig, Richard R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

G protein; GTPase activating protein; Structure based drug design

Indexed keywords

ETHER DERIVATIVE; N ACETYLVALYLLYSINE[CYSTEINYLTHREONYLGLUTAMYLISOLEUCYLCYSTEINE] GLUTAMYLAMIDE; PEPTIDE; PROTEIN INHIBITOR; RGS PROTEIN; RGS4 PROTEIN; RGS7 PROTEIN; RGS8 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; HEART ATRIUM; HEART MUSCLE CELL; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINE; ANIMALS; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GLYCINE; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTPASE-ACTIVATING PROTEINS; HUMANS; KINETICS; MALE; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PEPTIDES, CYCLIC; RATS; RATS, INBRED WKY; RGS PROTEINS; SERINE; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 33645849558     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2006.00373.x     Document Type: Article

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