N-Chlorosuccinimide is a convenient oxidant for the synthesis of 2,4-disubstituted 1,2,4-thiadiazolidine-3,5-diones

Tetrahedron Letters

Volumn 50, Issue 3, 2009, Pages 257-259

  Nasim, Shama ^a   Crooks, Peter A ^a  

^a University of Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 THIADIAZOLE DERIVATIVE; 1,2,4 THIADIAZOLIDINE 3,5 DIONE; CHLOROSUCCINIMIDE; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIPOLAR DISORDER; DRUG INDICATION; DRUG STRUCTURE; DRUG SYNTHESIS; GAS CHROMATOGRAPHY; LEUKEMIA; MASS SPECTROMETRY; MITSUNOBU REACTION; NON INSULIN DEPENDENT DIABETES MELLITUS; REACTION OPTIMIZATION;

EID: 57149128849     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2008.10.136     Document Type: Article

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12. 3 (10 mL/mmol) and NCS (4 mmol) was added in one portion. After stirring at rt for 12 h under argon and subsequently for 10 min in air, the reaction mixture was diluted with diethylether and filtered through a sintered glass funnel to remove unreacted NCS and the precipitated succinimide. The filtrate was concentrated under reduced pressure and subjected to column chromatography over silica gel, eluted with 15-20% diethylether-hexanes to isolate the pure product.
13. 2S) C, H, N.
14. 2S) C, H, N.
15. 2S) C, H, N.