Synthesis of some chalcones and pyrazolines carrying morpholinophenyl moiety as potential anti-inflammatory agents

Archiv der Pharmazie

Volumn 344, Issue 4, 2011, Pages 242-247

  Khalil, Omneya M ^a  

^a CAIRO UNIVERSITY   (Egypt)

Author keywords

Anti inflammatory activity; Chalcones; Pyrazolines

Indexed keywords

1 (4 MORPHOLINOPHENYL) 3 (2 THIENYL) 2 PROPEN 1 ONE; 3 (2 METHOXYPHENYL) 1 (4 MORPHOLINOPHENYL) 2 PROPEN 1 ONE; 3 (3,4 DIMETHOXYPHENYL) 1 (4 MORPHOLINOPHENYL) 2 PROPEN 1 ONE; 3 (3,4,5 TRIMETHOXYPHENYL) 1 (4 MORPHOLINOPHENYL) 2 PROPEN 1 ONE; 3 (3,5 DIMETHOXYPHENYL) 1 (4 MORPHOLINOPHENYL) 2 PROPEN 1 ONE; 3 (4 BROMOPHENYL) 1 (4 MORPHOLINOPHENYL) 2 PROPEN 1 ONE; 3 (4 MORPHOLINOPHENYL) 4,5 DIHYDRO 5 (2 THIENYL) 1H PYRAZOLE; 5 (2 METHOXYPHENYL) 4,5 DIHYDRO 3 (4 MORPHOLINOPHENYL) 1H PYRAZOLE; 5 (3,4 DIMETHOXYPHENYL) 4,5 DIHYDRO 3 (4 MORPHOLINOPHENYL) 1H PYRAZOLE; 5 (3,4,5 TRIMETHOXYPHENYL) 4,5 DIHYDRO 3 (4 MORPHOLINOPHENYL) 1H PYRAZOLE; 5 (3,5 DIMETHOXYPHENYL) 4,5 DIHYDRO 3 (4 MORPHOLINOPHENYL) 1H PYRAZOLE; 5 (4 BROMOPHENYL) 4,5 DIHYDRO 3 (4 MORPHOLINOPHENYL) 1H PYRAZOLE; 5 ARYL 3 (4 MORPHOLINOPHENYL) 4,5 DIHYDRO 1H PYRAZOLE; ANTIINFLAMMATORY AGENT; CARRAGEENAN; CHALCONE DERIVATIVE; INDOMETACIN; MORPHOLINE DERIVATIVE; PYRAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; EDEMA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHALCONES; CYCLIZATION; DISEASE MODELS, ANIMAL; EDEMA; MALE; MOLECULAR STRUCTURE; MORPHOLINES; PYRAZOLES; RATS;

EID: 79953795483     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.201000245     Document Type: Article

References (31)

1. S. K. Awasthi, N. Mishra, B. Kumar, M. Sharma, A. Bhattacharya, L. C. Mishra, V. K. Bhasin, Med. Chem. Res. 2009, 18, 407-420.
2. V. Tomar, G. Bhattacharjee, Kamaluddin, S. Rajakumar, K. Srivastava, S. K. Puri, Eur. J. Med. Chem. 2010, 45, 745-751.
3. Z. Nowakowska, B. Kȩdzia, G. Schroeder, Eur. J. Med. Chem. 2008, 43, 707-713.
4. M. A. Alvarez, N. B. Debattista, N. B. Pappano, Folia Microbiol. 2008, 53, 23-28.
5. M. Gopalakrishnan, J. Thanusu, V. Kanagarajan, R. Govindaraju, Med. Chem. Res. 2009, 18, 341-350.
6. M. Goniotaki, S. Hatziantoniou, K. Dimas, M. Wagner, C. Demetzos, J. Pharm. Pharmacol. 2004, 56, 1217-1224.
7. A. Modzelewska, C. Pettit, G. Achanta, N. E. Davidson, P. Huang, S. R. Khan, Bioorg. Med. Chem. 2006, 14, 3491-3495.
8. R. N. Gacche, N. A. Dhole, S. G. Kamble, B. P. Bandgar, J. Enzym. Inhib. Med. Chem. 2008, 23, 28-31.
9. T. Hirano, J. Arimitsu, S. Higa, T. Naka, A. Ogata, Y. Shima, M. Fujimoto, T. Yamadori, T. Ohkawara, Y. Kuwabara, M. Kawai, I. Kawase, T. Tanaka, Int. Arch. Allergy Immunol. 2006, 140, 150-156.
10. M. Satyanarayana, P. Tiwari, B. K. Tripathi, A. K. Srivastava, R. Pratap, Bioorg. Med. Chem. 2004, 12, 883-889.
11. F. Jin, X. Y. Jin, Y. L. Jin, D. W. Sohn, S.-A. Kim, D. H. Sohn, Y. C. Kim, H. S. Kim, Arch. Pharm. Res. 2007, 30, 1359-136.
12. X.-W. Zhang, D.-H. Zhao, Y.-C. Quan, L.-P. Sun, X.-M. Yin, L.-P. Guan, Med. Chem. Res. 2010, 19, 403-412.
13. M. Abid, A. Azam, Bioorg. Med. Chem. Lett. 2006, 16, 2812-2816.
14. M. Abid, A. R. Bhat, F. Athar, A. Azam, Eur. J. Med. Chem. 2009, 44, 417-425.
15. B. F. Abdel-Wahab, H. A. Abdel-Aziz, E. M. Ahmed, Eur. J. Med. Chem. 2009, 44, 2632-2635.
16. A. Sahoo, S. Yabanoglu, B. N. Sinha, G. Ucar, A. Basu, V. Jayaprakash, Bioorg. Med. Chem. Lett. 2010, 20, 132-136.
17. M. Shaharyar, A. A. Siddiqui, M. A. Ali, D. Sriram, P. Yogeeswari, Bioorg. Med. Chem. Lett. 2006, 16, 3947-3949.
18. M. A. Ali, M. Shaharyar, A. A. Siddiqui, Eur. J. Med. Chem. 2007, 42, 268-275.
19. Y. R. Prasad, A. L. Rao, L. Prasoona, K. Murali, P. R. Kumar, Bioorg. Med. Chem. Lett. 2005, 15, 5030-5034.
20. S. Gok, M. M. Demet, A. Ozdemir, G. Turan-Zitouni, Med. Chem. Res. 2010, 19, 94-101.
21. Z. Ozdemir, H. B. Kandilci, B. Gumusel, U. Calis, A. A. Bilgin, Eur. J. Med. Chem. 2007, 42, 373-379.
22. I. G. Rathish, K. Javed, S. Ahmad, S. Bano, M. S. Alam, K. K. Pillai, S. Singh, V. Bagchi, Bioorg. Med. Chem. Lett. 2009, 19, 255-258.
23. N. Gökhan-Kelekçi, S. Yabanoǧlu, E. Küpeli, U. Salgin, Ö. Özgen, G. Uçar, E. Yeşilada, E. Kendi, A. Yeşilada, A. A. Bilgin, Bioorg. Med. Chem. 2007, 15, 5775-5786.
24. M. Verma, V. R. Gujrati, M. Sharma, A. K. Saxena, T. N. Bhalla, J. N. Sinha, K. P. Bhargava, K. Shanker, Pharmacol. Res. Commun. 1984, 16, 9-20.
25. R. S. Joshi, P. G. Mandhane, S. D. Diwakar, S. K. Dabhade, C. H. Gill, Bioorg. Med. Chem. Lett. 2010, 20, 3721-3725.
26. P. Panneerselvam, R. R. Nair, G. Vijayalakshmi, E. H. Subramanian, S. K. Sridhar, Eur. J. Med. Chem. 2005, 40, 225-229.
27. P. Panneerselvam, M. Gnanarupa Priya, N. R. Kumar, G. Saravanan, Indian J. Pharm. Sci. 2009, 71, 428-432.
28. T. P. Robinson, R. B. Hubbard, T. J. Ehlers, J. L. Arbiser, D. J. Goldsmith, J. P. Bowen, Bioorg. Med. Chem. 2005, 13, 4007-4013.
29. S. H. Jung, S. Y. Park, Y. Kim-Pak, H. K. Lee, K. S. Park, K. H. Shin, K. Ohuchi, H.-K. Shin, S. R. Keum, S. S. Lim, Chem. Pharm. Bull. 2006, 54, 368-371.
30. U. Bauer, B. J. Egner, I. Nilsson, M. Berghult, Tetrahedron Lett. 2000, 41, 2713-2717.
31. C. A. Winter, E. A. Fisley, G. W. Nuss, Proc. Soc. Exp. Biol. Med. 1962, 111, 544-547.