Synthesis and evaluation of antiinflammatory activity of substituted chalcone derivatives

Medicinal Chemistry Research

Volumn 19, Issue 4, 2010, Pages 403-412

  Zhang, Xue Wu ^a   Zhao, Dong Hai ^b   Quan, Ying Chun ^a   Sun, Liang Peng ^a   Yin, Xiu Mei ^a   Guan, Li Ping ^a  

^a YANBIAN UNIVERSITY   (China)

^b JILIN MEDICAL COLLEGE   (China)

Author keywords

Antiinflammatory; Chalcone derivatives; Ibuprofen; Synthesis

Indexed keywords

1 (2,4 DIHYDROXYPHENYL) 3 (4 DIMETHYLAMINO)PHENYL)PROP 2 EN 1 ONE; 3 (4 CHLOROPHENYL) 1 (2,4 DIHYDROXYPHENYL)PROP 2 EN 1 ONE; CHALCONE DERIVATIVE; IBUPROFEN; UNCLASSIFIED DRUG; XYLENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; EDEMA; IN VIVO STUDY; MOUSE; NONHUMAN; OTITIS; STRUCTURE ACTIVITY RELATION;

EID: 77954085989     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-009-9202-z     Document Type: Article

References (18)

1. JF Ballesteros MJ Sanz A Ubeda MA Miranda S Iborra M Payá MJ Alcaraz 1995 Synthesis and pharmacological evaluation of 2'-hydroxychalcones and flavones as inhibitors of inflammatory mediators generation J Med Chem 38 2794 2797 10.1021/jm00014a032 10.1021/jm00014a032 1:CAS:528:DyaK2MXms1Gnsrc%3D 7629818
2. AA Bekhit NS Habib A Din A Bekhit 2001 Synthesis and antimicrobial evaluation of chalcone and syndrome derivatives of 4(3H)-quinazolinone Boll Chim Farm 140 297 301 1:CAS:528:DC%2BD3MXot1CrsLo%3D 11680081
3. Fan NT (1992) Organic synthesis dictionary (in Chinese). Beijing University of Engineering Press, Beijing, p 519
4. LP Guan JX Nan XJ Jin QH Jin KC Kwak KY Chai ZS Quan 2005 Protective effects of chalcone derivatives for acute liver Arch Pharm Res 28 81 86 10.1007/BF02975140 10.1007/BF02975140 1:CAS:528:DC%2BD2MXht12htrY%3D 15742813 (Pubitemid 44698770)
5. J Hallas J Lauritsen HD Villadsen LF Gram 1995 Nonsteroidal anti-inflammatory drugs and upper gastrointestinal bleeding, identifying high-risk groups by excess risk estimates Scand J Gastroenterol 30 438 444 10.3109/00365529509093304 1:STN:280:DyaK2MzmsFOlsg%3D%3D 7638569
6. HK Hiseh TH Lee JP Wang JJ Wang CN Lin 1998 Synthesis and antiinflammatory effects of chalcones and related compounds Pharm Res 15 39 46 10.1023/A:1011940401754 10.1023/A:1011940401754 (Pubitemid 28080864)
7. SK Kumar E Hager C Pettit H Gurulingppa NE Davidson SR Khan 2003 Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents J Med Chem 46 2813 2815 10.1021/jm030213+ 10.1021/jm030213+ 1:CAS:528:DC%2BD3sXktFSqsrs%3D 12825923 (Pubitemid 36775907)
8. SH Lee GS Seo JY Kim XY Lin H-D Kim DH Sohn 2006 Heme oxygenase 1 mediates antiinflammatory effects of 2',4',6'-tris(methoxymethoxy)chalcone Eur J Pharm 532 178 186 10.1016/j.ejphar.2006.01.005 10.1016/j.ejphar.2006.01.005 1:CAS:528:DC%2BD28XhvVWltr8%3D
9. M Liu P Wilairat ML Go 2001 Antimalarial alkoxylated and hydroxylated chalcones [corrected]: structure-activity relationship analysis J Med Chem 44 4443 4452 10.1021/jm0101747 10.1021/jm0101747 1:CAS:528:DC%2BD3MXnvVGnurc%3D 11728189 (Pubitemid 33131668)
10. SN Lopez MV Castelli SA Zacchino JN Dominguez G Lobo J Chrris-Charriss JC Cortes JC Ribas C Devia AM Rodriguez RD Enrizz 2001 In vitro antifungal evaluation and structure-activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties against polymers of the fungal cell wall Bioorg Med Chem 9 1999 2013 10.1016/S0968-0896(01) 00116-X 10.1016/S0968-0896(01)00116-X 1:CAS:528:DC%2BD3MXlvFWiur0%3D 11504637 (Pubitemid 32739188)
11. D McCarthy 1998 Nonsteroidal antiinflammatory drug-related gastrointestinal toxicity: definition and epidemiology Am J Med 105 5A 3S 9S 10.1016/S0002-9343(98)00274-5 10.1016/S0002-9343(98)00274-5 1:CAS:528: DyaK1MXitFChsw%3D%3D 9855169 (Pubitemid 28553709)
12. +-ATPase by the antiulcer agent, sofalcone Biochem Pharmacol 42 1447 1451 10.1016/0006-2952(91)90458-H 10.1016/0006-2952(91)90458-H 1:CAS:528:DyaK3MXmsVOrsL0%3D 1656986
13. JB Raskin 1999 Gastrointestinal effects of nonsteroidal antiinflammatory therapy Am J Med 106 5B 3S 12S 10.1016/S0002-9343(99)00112-6 10.1016/S0002-9343(99)00112-6 1:CAS:528:DyaK1MXjvFOnsrc%3D 10390123 (Pubitemid 29268659)
14. S Sogawa Y Nihro H Ueda A Izumi T Miki H Matsumoto T Satoh 1993 3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors J Med Chem 36 3904 3909 10.1021/jm00076a019 10.1021/jm00076a019 1:CAS:528:DyaK2cXhtleqt7g%3D 8254620 (Pubitemid 24006720)
15. JR Van RM Botting 1995 New insights into the mode of action of antiinflammatory drugs Inflamm Res 44 1 10 10.1007/BF01630479 10.1007/BF01630479
16. GS Viana MA Bandeira FJ Matos 2003 Analgesic and antiinflammatory effects of chalcones isolated from Myracrodruon urundeuva allemao Phytomedicine 10 189 196 10.1078/094471103321659924 10.1078/094471103321659924 1:CAS:528: DC%2BD3sXksFGktL0%3D 12725575 (Pubitemid 36433216)
17. SJ Won CT Liu LT Tsao JR Weng HH Ko JP Wanf CN Lin 2005 Synthetic chalcones as potential antiinflammatory and cancer chemopreventive agents Eur J Med Chem 40 103 112 10.1016/j.ejmech.2004.09.006 10.1016/j.ejmech.2004.09.006 1:CAS:528:DC%2BD2MXjtF2jtA%3D%3D 15642415 (Pubitemid 40092383)
18. JH Wu XH Wang YH Yi KH Lee 2003 Anti-AIDS agents 54: a potent anti-HIV chalcone and flavonoids from genus Desmos Bioorg Med Chem Lett 13 1813 1815 10.1016/S0960-894X(03)00197-5 10.1016/S0960-894X(03)00197-5 1:CAS:528: DC%2BD3sXjt1Kjtr0%3D 12729671 (Pubitemid 36561171)