The BH3-mimetic ABT-737 targets the apoptotic machinery in cholangiocarcinoma cell lines resulting in synergistic interactions with zoledronic acid

Cancer Chemotherapy and Pharmacology

Volumn 67, Issue 3, 2011, Pages 557-567

  Romani, Antonello A ^a   Desenzani, Silvia ^a   Morganti, Marina M ^a   Baroni, Maria Cristina ^a   Borghetti, Angelo F ^a   Soliani, Paolo ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

ABT 737; Apoptosis; BCL 2; Cholangiocarcinoma; Zoledronic acid

Indexed keywords

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; CASPASE 3; HEAT SHOCK PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; ZOLEDRONIC ACID; ABT-737; ANTINEOPLASTIC AGENT; BIPHENYL DERIVATIVE; BISPHOSPHONIC ACID DERIVATIVE; IMIDAZOLE DERIVATIVE; NITROPHENOL; PIPERAZINE DERIVATIVE; SULFONAMIDE;

APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CELL SURVIVAL; COLONY FORMING CELL; CYTOSTASIS; DRUG MEGADOSE; DRUG POTENTIATION; DRUG TARGETING; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; TARGET CELL DESTRUCTION; BILE DUCT TUMOR; CELL CYCLE S PHASE; DRUG DELIVERY SYSTEM; DRUG EFFECT; GENE EXPRESSION REGULATION; INTRAHEPATIC BILE DUCT; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; CHOLANGIOCARCINOMA; DIPHOSPHONATES; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; NITROPHENOLS; PIPERAZINES; S PHASE; SULFONAMIDES;

EID: 79953774340     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-010-1345-6     Document Type: Article

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