Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3938-3946

  Homes, Taryn P ^a   Mattner, Filomena ^b   Keller, Paul A ^a   Katsifis, Andrew ^b  

^a UNIVERSITY OF WOLLONGONG   (Australia)

^b AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

Author keywords

N,N Dialkyl 2 phenylindol 3 ylglyoxylamides; Peripheral benzodiazepine binding sites; Radioiodination; SPECT

Indexed keywords

AMIDE; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR; BROMINE; DIETHYLAMINE; FLUMAZENIL; IODINE; IODINE 123; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N,N DIETHYL [5 CHLORO 2 (4 IODOPHENYL)INDOL 3 YL]GLYOXYLAMIDE; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; DRUG BINDING; DRUG BINDING SITE; IMAGING; IN VITRO STUDY; INFLAMMATION; ISOTOPE LABELING; KIDNEY CELL; MALE; MITOCHONDRIAL MEMBRANE; NERVE DEGENERATION; NONHUMAN; PHOTON EMISSION TOMOGRAPHY; RAT; RECEPTOR AFFINITY; SYNTHESIS; TUMOR;

AMIDES; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CEREBRAL CORTEX; FLUMAZENIL; GLYOXYLATES; INDOLES; INTRACELLULAR MEMBRANES; ISOQUINOLINES; KIDNEY; LIGANDS; MALE; MITOCHONDRIA; MOLECULAR STRUCTURE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 33646034594     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.039     Document Type: Article

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