Loss of p21Sdi1 expression in senescent cells after DNA damage accompanied with increase of miR-93 expression and reduced p53 interaction with p21Sdi1 gene promoter

Biochemical and Biophysical Research Communications

Volumn 407, Issue 2, 2011, Pages 406-411

  Choi, Ok Ran ^a   Lim, In Kyoung ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Doxorubicin; HDF; MiR 93; P21sdi1 cip1 waf1; P53; Senescence

Indexed keywords

ACTIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; DOXORUBICIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROCASPASE 3; PROTEIN P21; PROTEIN P53;

ADULT; AGED; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DIPLOIDY; DNA DAMAGE; FIBROBLAST; GENE EXPRESSION; GENE INDUCTION; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SENESCENCE; X RAY;

ADULT; AGED; CELL AGING; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHILD, PRESCHOOL; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA DAMAGE; FIBROBLASTS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; PROMOTER REGIONS, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; YOUNG ADULT;

EID: 79953716302     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.03.038     Document Type: Article

References (32)

1. Campisi J. Suppressing cancer: the importance of being senescent. Science 2005, 309:886-887.
2. Di Micco R., Fumagalli M., d'Adda di Fagagna F. Breaking news: high-speed race ends in arrest - how oncogenes induce senescence. Trends Cell Biol. 2007, 17:529-536.
3. DePinho R.A. The age of cancer. Nature 2000, 408:248-254.
4. Hara E., Tsurui H., Shinozaki A., Nakada S., Oda K. Cooperative effect of antisense-Rb and antisense-p53 oligomers on the extension of life span in human diploid fibroblasts, TIG-1. Biochem. Biophys. Res. Commun. 1991, 179:528-534.
5. Shay J.W., Pereira-Smith O.M., Wright W.E. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 1991, 196:33-39.
6. Vaziri H., Benchimol S. Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase. Oncogene 1999, 18:7676-7680.
7. el-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parsons R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B. WAF1, a potential mediator of p53 tumor suppression. Cell 1993, 75:817-825.
8. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 1993, 75:805-816.
9. Noda A., Ning Y., Venable S.F., Pereira-Smith O.M., Smith J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell. Res. 1994, 211:90-98.
10. Voorhoeve P.M., le Sage C., Schrier M., Gillis A.J., Stoop H., Nagel R., Liu Y.P., van Duijse J., Drost J., Griekspoor A., Zlotorynski E., Yabuta N., De Vita G., Nojima H., Looijenga L.H., Agami R. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006, 124:1169-1181.
11. Wei W., Jobling W.A., Chen W., Hahn W.C., Sedivy J.M. Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts. Mol. Cell. Biol. 2003, 23:2859-2870.
12. Chang B.D., Swift M.E., Shen M., Fang J., Broude E.V., Roninson I.B. Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent. Proc. Natl. Acad. Sci. USA 2002, 99:389-394.
13. Jackson J.G., Pereira-Smith O.M. P53 is preferentially recruited to the promoters of growth arrest genes p21 and GADD45 during replicative senescence of normal human fibroblasts. Cancer Res. 2006, 66:8356-8360.
14. Smogorzewska A., De Lange T. Different telomere damage signaling pathways in human and mouse cells. EMBO J. 2002, 21:4338-4348.
15. Kim H.S., Lim I.K. Phosphorylated extracellular signal-regulated protein kinases 1 and 2 phosphorylate Sp1 on serine 59 and regulate cellular senescence via transcription of p21Sdi1/Cip1/Waf1. J. Biol. Chem. 2009, 284:15475-15486.
16. Mao Z., Bozzella M., Seluanov A., Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst.) 2008, 7:1765-1771.
17. Mao Z., Bozzella M., Seluanov A., Gorbunova V. DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells. Cell Cycle 2008, 7:2902-2906.
18. Seluanov A., Danek J., Hause N., Gorbunova V. Changes in the level and distribution of Ku proteins during cellular senescence. DNA Repair (Amst.) 2007, 6:1740-1748.
19. Seluanov A., Mittelman D., Pereira-Smith O.M., Wilson J.H., Gorbunova V. DNA end joining becomes less efficient and more error-prone during cellular senescence. Proc. Natl. Acad. Sci. USA 2004, 101:7624-7629.
20. Kwak I.H., Kim H.S., Choi O.R., Ryu M.S., Lim I.K. Nuclear accumulation of globular actin as a cellular senescence marker. Cancer Res. 2004, 64:572-580.
21. Lim I.K., Won Hong K., Kwak I.H., Yoon G., Park S.C. Cytoplasmic retention of p-Erk1/2 and nuclear accumulation of actin proteins during cellular senescence in human diploid fibroblasts. Mech. Ageing Dev. 2000, 119:113-130.
22. Kim H.S., Song M.C., Kwak I.H., Park T.J., Lim I.K. Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence. J. Biol. Chem. 2003, 278:37497-37510.
23. Kaproth-Joslin K.A., Li X., Reks S.E., Kelley G.G. Phospholipase C delta 1 regulates cell proliferation and cell-cycle progression from G1- to S-phase by control of cyclin E-CDK2 activity. Biochem. J. 2008, 415:439-448.
24. Saramaki A., Banwell C.M., Campbell M.J., Carlberg C. Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor. Nucleic Acids Res. 2006, 34:543-554.
25. Ivanovska I., Ball A.S., Diaz R.L., Magnus J.F., Kibukawa M., Schelter J.M., Kobayashi S.V., Lim L., Burchard J., Jackson A.L., Linsley P.S., Cleary M.A. MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol. Cell. Biol. 2008, 28:2167-2174.
26. Freund A., Orjalo A.V., Desprez P.Y., Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol. Med. 2010, 16:238-246.
27. Coppe J.P., Patil C.K., Rodier F., Sun Y., Munoz D.P., Goldstein J., Nelson P.S., Desprez P.Y., Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008, 6:2853-2868.
28. Borgdorff V., Lleonart M.E., Bishop C.L., Fessart D., Bergin A.H., Overhoff M.G., Beach D.H. Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21(Waf1/Cip1). Oncogene 2010, 29:2262-2271.
29. Petrocca F., Visone R., Onelli M.R., Shah M.H., Nicoloso M.S., de Martino I., Iliopoulos D., Pilozzi E., Liu C.G., Negrini M., Cavazzini L., Volinia S., Alder H., Ruco L.P., Baldassarre G., Croce C.M., Vecchione A. E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell 2008, 13:272-286.
30. Wong T.S., Liu X.B., Wong B.Y., Ng R.W., Yuen A.P., Wei W.I. Mature miR-184 as potential oncogenic microRNA of squamous cell carcinoma of tongue. Clin. Cancer Res. 2008, 14:2588-2592.
31. Huang Q., Gumireddy K., Schrier M., le Sage C., Nagel R., Nair S., Egan D.A., Li A., Huang G., Klein-Szanto A.J., Gimotty P.A., Katsaros D., Coukos G., Zhang L., Pure E., Agami R. The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. Nat. Cell Biol. 2008, 10:202-210.
32. Rodier F., Coppe J.P., Patil C.K., Hoeijmakers W.A., Munoz D.P., Raza S.R., Freund A., Campeau E., Davalos A.R., Campisi J. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat. Cell Biol. 2009, 11:973-979.