Antihypercholesterolemia property and fatty acid composition of mardi-produced virgin coconut oils

African Journal of Pharmacy and Pharmacology

Volumn 4, Issue 9, 2010, Pages 636-644

  Zakaria, Z A ^a   Ahmad, Z ^a   Somchit, M N ^a   Arifah, A K ^a   Khairi, H M ^a   Sulaiman, M R ^a   Teh, L K ^b   Salleh, M Z ^b   Long, K ^c  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^c MALAYSIAN AGRICULTURAL RESEARCH AND DEVELOPMENT INSTITUTE MARDI   (Malaysia)

Author keywords

Antihypercholesterolemia; Atorvastatin; Virgin coconut oil

Indexed keywords

ATORVASTATIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; VIRGIN COCONUT OIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DETERMINATION; DRUG MECHANISM; DRUG RESPONSE; HYPERCHOLESTEROLEMIA; LIPID COMPOSITION; MALE; NONHUMAN; RABBIT; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 78649887519     PISSN: None     EISSN: 19960816     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Romero-Corral A, Somers VK, Korinek J, Sierra-Johnson J, Thomas RJ, Allison TG, Lopez-Jimenez F (2006). Update in prevention of atherosclerotic heart disease. Management of major cardiovascular risk factors. Rev. Invest. Clin., 58: 237-244.
2. Duff GL, Macmillian GC (1951). Pathology of atherosclerosis. Am. J. Med., 11: 92-108.
3. Goldstein JL, Ho YK, Basu SK, Brown MS (1979). Binding site macrophage that indicate uptake and degradation of acetylated low density lipoprotein and producing massive cholesterol deposit. Proc. Natl. Acad. Sci., 76: 333-337.
4. Moosmann B, Behl C (2004). Selenoprotein synthesis and side-effects of statins. Lancet, 363: 892-894.
5. Sajjadi SE, Movahedian A, Yektaian A (1998). Antihyperlipidemic effect of hydro alcoholic extract and polyphenolic fraction from Dracocephalum kotchyi. Bios. Pharm. Acta Helv., 73: 167-170.
6. Movahedian A, Sadeghi H, Ghannadi A, Gharavi M, Azarpajooh S (2006). Hypolipidemic activity of Allium porrum L. in cholesterol-fed rabbits. J. Med. Food, 9: 98-101.
7. Prasad K (2005). Hypercholesterolemic and antiatherosclerotic effect of flax lignin complex isolated from flaxseed. Atherosclerosis, 179: 269- 275.
8. Che Man YB, Marina AM (2006). Medium chain triacylglycerol. In: Shahidi F (ed) nutriaceutical and specialty lipids and their co-products. Taylor & Francis, Boca Raton, pp. 27-56.
9. Marina AM, Che Man YB, Nazimah AH (2009). Chemical properties of virgin coconut oil. J. Am. Oil Chem. Soc., 86: 301-307.
10. Nevin KG, Rajamohan T (2004). Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation. Clin. Biochem., 37: 830-835.
11. Nevin KG, Rajamohan T (2005). Virgin coconut oil supplemented diet increases the antioxidant status in rats. Food Chem., 99: 260-266.
12. Nevin KG, Rajamohan T (2007). Influence of virgin coconut oil on blood coagulation factors, lipid levels and LDL oxidation in cholesterol fed Sprague-Dawley rats. Eur. e-J. Clin. Nutr. Metabol., e1-e8.
13. Zimmermann M (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110.
14. Zuraini A, Ros Aziah MR, Arifah AK, Sulaiman MR, Somchit MN (2006). Aqueous extracts on Andographis paniculata improves lipid profiles of rats fed with high cholesterol diet. Int. J. Pharmacol., 2: 45-49.
15. Butte W (1983). Rapid method for the determination of fatty acid profiles from fats and oils using trimethylsulfonium hydroxide for transesterification. J. Chromatogr., 261: 142-145.
16. Eder K, Brandsch C (2002). Effect of fatty acid composition of rapeseed oil on plasma lipids, fatty acid composition of tissues and susceptibility of low-density lipoprotein to lipid peroxidation in cholesterol-fed hamsters. Eur. J. Lipid Sci. Technol., 104: 3-13.
17. Yokozawa T, Ishida A, Cho EJ, Nakagawa T (2003). The effects of Coptids Rhizoma extract on hypercholeterolemic animal model. Phytomedicine, 10: 17-22.
18. Kritchevsky D, Tepper SA, Bisec G, Klurfeld DM (1983). Influence of cocoa butter on cholesterol metabolism in rats: Comparison with corn oil, coconut oil and palm oil. Nutr. Res., 3: 229-236.
19. Kritchevsky D (1985). Lipid metabolism and coronary heart disease. In: Dietary fiber-depleted foods and disease (Trowell, H.) Press, London, UK.
20. Eckarstein V, Noter JR, Assmann G (2002). High density lipoproteins and atherosclerosis. Role of cholesterol efflux and reverse cholesterol transport. Arterioscler Thromb Vasc. Biol., 21: 13-27.
21. Tebib K, Besancon P, Rovanet JM (1994). Dietary grape seed tannins effect lipoproteins lipoprotein lipase and tissue lipids in rats fed hypercholesterolemic diets. J. Nutr., 124: 2451-2547.
22. Cox C, Mann J, Sutherland W, Chisholm A, Skeaff M (1995). Effects of coconut oil, butter and safflower oil on lipids and lipoproteins in persons with moderately elevated cholesterol levels. J. Lipid Res., 36: 1787-1795.
23. Zakaria ZA, Sulaiman MR, Goh YM, Mat Jais AM, Somchit MN (2007). Determination of the amino acid and fatty acid compositions of the aqueous extract of Channa striatus (Haruan) that exhibits antinociceptive activity. Clin. Exp. Pharmacol. Physiol., 34: 198-204.