Atypical N-terminal extensions confer novel regulatory properties on GTP cyclohydrolase isoforms in Drosophila melanogaster

Journal of Biological Chemistry

Volumn 281, Issue 44, 2006, Pages 33302-33312

  Funderburk, Christopher D ^a,b   Bowling, Kevin M ^a   Xu, Dong ^a,c   Huang, Zhinong ^a,d   O'Donnell, Janis M ^a  

^a UNIVERSITY OF ALABAMA   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; DISEASES; ENZYME INHIBITION; NEUROLOGY; NITROGEN COMPOUNDS;

COFACTOR POOLS; HEREDITARY DISEASES; NITRIC OXIDES; PHOSPHORYLATION;

ENZYMES;

GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; SERINE; 2,4 DIAMINOHYPOXANTHINE; 2,4-DIAMINOHYPOXANTHINE; BORANE DERIVATIVE; HYPOXANTHINE DERIVATIVE; ISOENZYME; PROTEIN KINASE B; RECOMBINANT PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME REGULATION; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS;

DROSOPHILA MELANOGASTER; MAMMALIA;

ANIMALS; BOROHYDRIDES; DROSOPHILA MELANOGASTER; GTP CYCLOHYDROLASE; HYPOXANTHINES; ISOENZYMES; KINETICS; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECOMBINANT PROTEINS;

EID: 33845929993     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602196200     Document Type: Article

References (56)

1. Nagatsu, T., Levitt, M., and Udenfriend, S. (1964) J. Biol. Chem. 139, 2910-2917
2. Lovenberg, W., Jequier, E., and Sjoerdsma, A. (1967) Science 155, 217-219
3. Kaufman, S. (1963) Proc. Natl. Acad. Sci. U. S. A. 50, 1085-1093
4. Tiets, A., Lindberg, M., and Kennedy, E. (1964) J. Biol. Chem. 239, 4081-4090
5. Kaufman, S., Pollock, R. J., Summer, G. K., Das, A. K., and Hajra, A. K. (1990) Biochim. Biophys. Acta 1040, 19-27
6. Tayeh, M. A., and Marletta, M. A. (1989) J. Biol. Chem. 264, 19654-19658
7. Kwon, N. S., Nathan, C. F., and Stuehr, D. J. (1989) J. Biol. Chem. 264, 20496-20501
8. Brown, G. M. (1985) in Folates and Pterins (Blakely, R. J., and Benkovic, S. J., eds) pp. 115-154, John Wiley and Sons, New York
9. Ichinose, H., Ohye, T., Takahashi, E., Seki, N., Hori, T., Segawa, M., Nomura, Y., Endo, K., Tanaka, H., Tsuji, S., Fujita, K., and Nagatsu, T. (1994) Nat. Genet. 8, 236-242
10. Nagatsu, T., and Ichinose, H. (1997) J. Neurol. Transm. Suppl. 49, 203-209
11. Hirano, M., Yangihara, T., and Ueno, S. (1998) Ann. Neurol. 44, 365-371
12. Thöny, B., and Blau, N. (1997) Hum. Mutat. 10, 11-20
13. Curtius, H. C., Niederwieser, A., Levine, R., and Muldner, H. (1984) Adv. Neurol. 40, 463-466
14. Barford, P. A., Blair, J. A., Eggar, C., Hamon, C., Morar, C., and Whitburn, S. B. (1984) J. Neurol. Neurosurg. Psychiatry 47, 736-738
15. Bottiglieri, T., Hyland, K., Laundy, M., Godfrey, P., Carney, M. W., Toone, B. K., and Reynolds, E. H. (1992) Psychol. Med. 22, 871-876
16. Shinozaki, K., Nishio, Y., Yoshida, Y., Koya, D., Ayajiki, K., Masada, M., Kashiwagi, A., and Okamura, T. (2005) J. Cardiovasc. Pharmacol. 46, 505-512
17. Kase, H., Hashikabe, Y., Uchida, K., Nakanishi, N., and Hattori, Y. (2005) J. Hypertens. 23, 1375-1382
18. Higashi, Y., Sasaki, S., Nakagawa, K., Kimura, M., Noma, K., Hara, K., Jitsuiki, D., Goto, C., Oshima, T., Chayama, K., and Yoshizumi, M. (2006) Atherosclerosis 186, 390-395
19. Harada, T., Kagamiyama, H., and Hatakeyama, K. (1993) Science 260, 1507-1510
20. Milstein, S., Jaffe, H., Kowlessur, D., and Bonner, T. I. (1996) J. Biol. Chem. 271, 19743-19751
21. Maita, N., Okada, K., Hirotsu, S., Hatakeyama, K., and Hakoshima, T. (2001) Acta Crystallogr. Sect. D Biol. Crystallogr. 57, 1153-1156
22. Bader, G., Schiffmann, S., Herrmann, A., Fischer, M., Gütlich, M., Auerbach, G., Ploom, T., Bacher, A., Huber, R., and Lemm, T. (2001) J. Mol. Biol. 312, 1051-1057
23. Maita, N., Hatakeyama, K., Okada, K., and Hakoshima, T. (2004) J. Biol. Chem. 279, 51534-51540
24. Mitchell, B. M., Dorrance, A. M., and Webb, R. C. (2003) Am. J. Physiol. 285, H2165-H2170
25. Mitchell, B. M., Dorrance, A. M., and Webb, R. C. (2004) J. Cardiovasc. Pharmacol. 43, 758-763
26. Xie, L., Smith, J. A., and Gross, S. S. (1998) J. Biol. Chem. 273, 21091-21098
27. Kolinsky, M. A., and Gross, S. S. (2004) J. Biol. Chem. 279, 40677-40682
28. Suzuki, S., Watanabe, Y., Tsubokura, S., Kagamiyama, H., and Hayaishi, O. (1988) Brain Res. 446, 1-10
29. Cotton, R. G. (1986) J. Inherit. Metab. Dis. 9, 4-14
30. Gütlich, M., Jaeger, E., Rücknagel, K. P., Werner, T., Rödl, W., Ziegler, I., and Bacher, A. (1994) Biochem. J. 302, 215-221
31. Hwu, W. L., Yeh, H. Y., Fang, S. W., Chiang, H. S., Chiou, Y. W., and Lee, Y. M. (2003) Biochem. Biophys. Res. Commun. 306, 937-942
32. Hesslinger, C., Kremmer, E., Hültner, L., Ueffing, M., and Ziegler, I. (1998) J. Biol. Chem. 273, 21616-21622
33. Lapize, C., Plüss, C., Werner, E. R., Huwiler, A., and Pfeilschifter, J. (1998) Biochem. Biophys. Res. Commun. 251, 802-805
34. Weisberg, E. P., and O'Donnell, J. M. (1986) J. Biol. Chem. 261, 1453-1458
35. Mackay, W. J., and O'Donnell, J. M. (1983) Genetics 105, 35-53
36. Mackay, W. J., Reynolds, E. R., and O'Donnell, J. M. (1985) Genetics 111, 885-904
37. Reynolds, R. E., and O'Donnell, J. M. (1988) Genetics 119, 609-617
38. McLean, J. R., Krishnakumar, S., and O'Donnell, J. M. (1993) J. Biol. Chem. 268, 27191-27197
39. Chen, X., Reynolds, E. R., Ranganayakulu, G., and O'Donnell, J. M. (1994) J. Cell Sci. 107, 3501-3513
40. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
41. Edgar, R. C. (2004) Nucleic Acids Res. 32, 1792-1797
42. Clamp, M., Cuff, J., Searle, S. M., and Barton, G. J. (2004) Bioinformatics 12, 426-427
43. Henikoff, S., and Henikoff, J. G. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 10915-10919
44. Kolinsky, M. A., and Gross, S. S. (2004) in Pterins, Folates and Neurotransmitters in Molecular Medicine (Blau, N., and Thöny, B., eds) pp. 22-27, SPS Publications, Heilbronn, Germany
45. Viveros, O. H., Lee, C. L., Abou-Donia, M. M., Nixon, J. C., and Nichol, C. A. (1981) Science 213, 349-350
46. Hatakeyama, K., Inoue, Y., Harada, T., and Kagamiyama, H. (1991) J. Biol. Chem. 266, 765-769
47. Togari, A., Ichinose, H., Matsumoto, S., Fujita, K., and Nagatsu, T. (1992) Biochem. Biophys. Res. Commun. 187, 359-365
48. Schoedon, G., Redweik, U., and Curtius, H. C. (1989) Eur. J. Biochem. 178, 627-634
49. Hatakeyama, K., Harada, T., Suzuki, S., Watanabe, Y., and Kagamiyama, H. (1989) J. Biol. Chem. 264, 21660-21664
50. Auerbach, G., Herrmann, A., Bracher, A., Bader, G., Gütlich, M., Fisher, M., Neukamm, M., Garrido-Franco, M., Richardson, J., Nar, H., Huber, R., and Bacher, A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 13567-13572
51. Futahashi, R., and Fujiwara, H. (2006) Insect Biochem. Mol. Biol. 36, 63-70
52. Blom, N., Gammeltoft, S., and Brunak, S. (1999) J. Mol. Biol. 294, 1351-1362
53. Kapatos, G., and Hirayama, K. (1992) J. Neurochem. 59, 2048-2055
54. Kure, S., Hou, D., Ohura, T., Iwamoto, H., Suzuki, S., Sugiyama, N., Sakamoto, O., Fujii, K., Matsubara, Y., and Narisawa, K. (1999) J. Pediatr. 135, 375-378
55. Meininger, C. J., Cai, S., Parker, J. L., Channon, K. M., Kelly, K. A., Becker, E. J., Wood, M. K., Wade, L. A., and Wu, G. (2004) FASEB J. 18, 1900-1902
56. Krishnakumar, S., Burton, D., Rasco, J., Chen, X., and O'Donnell, J. (2000) J. Neurogenet. 14, 1-23