Inhibitors of Helicobacter pylori protease HtrA found by 'virtual ligand' screening combat bacterial invasion of epithelia

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Löwer, Martin ^a   Geppert, Tim ^c   Schneider, Petra ^c   Hoy, Benjamin ^b   Wessler, Silja ^b   Schneider, Gisbert ^c  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF SALZBURG   (Austria)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN; SERINE PROTEINASE; SERINE PROTEINASE HIGH TEMPERATURE REQUIREMENT A; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; UVOMORULIN; BACTERIAL PROTEIN; PEPTIDE HYDROLASE; PROTEINASE INHIBITOR;

ARTICLE; BACTERIUM ADHERENCE; BINDING SITE; CELL INVASION; COMPUTER ANALYSIS; CONTROLLED STUDY; DRUG SCREENING; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; INTESTINE EPITHELIUM CELL; LIGAND BINDING; MOLECULAR DOCKING; NONHUMAN; PHARMACOPHORE; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY; WOUND HEALING; ALGORITHM; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; METABOLISM; PHYSIOLOGY; STRUCTURE ACTIVITY RELATION; THEORETICAL MODEL; TUMOR CELL LINE;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

ALGORITHMS; BACTERIAL PROTEINS; CELL LINE, TUMOR; HELICOBACTER PYLORI; HUMANS; MODELS, THEORETICAL; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953305875     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017986     Document Type: Article

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