Control of PKA stability and signalling by the RING ligase praja2

Nature Cell Biology

Volumn 13, Issue 4, 2011, Pages 412-424

  Lignitto, Luca ^a   Carlucci, Annalisa ^a   Sepe, Maria ^a   Stefan, Eduard ^b   Cuomo, Ornella ^a   Nisticó, Robert ^c,d   Scorziello, Antonella ^a   Savoia, Claudia ^a   Garbi, Corrado ^a   Annunziato, Lucio ^a   Feliciello, Antonio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF INNSBRUCK   (Austria)

^c UNIVERSITY OF CALABRIA   (Italy)

^d IRCCS FONDAZIONE SANTA LUCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEASOME; PROTEIN PRAJA2; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COMPARTMENTALIZATION; CELL NUCLEUS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STABILITY; ENZYME SUBSTRATE; FEMALE; HUMAN; HUMAN CELL; LONG TERM MEMORY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; SIGNAL TRANSDUCTION; UBIQUITINATION;

A KINASE ANCHOR PROTEINS; ANIMALS; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; ENZYME ACTIVATION; ENZYME STABILITY; HEK293 CELLS; HUMANS; LONG-TERM POTENTIATION; MICE; NEUROBLASTOMA; NEURONS; PROTEIN SUBUNITS; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES; UBIQUITIN-PROTEIN LIGASES;

MAMMALIA;

EID: 79953296182     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb2209     Document Type: Article

References (48)

1. Taylor, S. S. et al. Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design. Biochim. Biophys. Acta 1784, 16-26 (2008).
2. Amieux, P. S. & McKnight, G. S. The essential role of RI in the maintenance of regulated PKA activity. Ann. NY Acad. Sci. 968, 75-95 (2002). (Pubitemid 34721873)
3. Feliciello, A., Gottesman, M. E. & Avvedimento, E. V. The biological functions of A-kinase anchor proteins. J. Mol. Biol. 308, 99-114 (2001). (Pubitemid 33043558)
4. Tasken, K. & Aandahl, E. M. Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol. Rev. 84, 137-167 (2004). (Pubitemid 38049878)
5. Beene, D. L. & Scott, J. D. A-kinase anchoring proteins take shape. Curr. Opin. Cell Biol. 19, 192-198 (2007). (Pubitemid 46394601)
6. Dell'Acqua, M. L. et al. Regulation of neuronal PKA signaling through AKAP targeting dynamics. Eur. J. Cell Biol. 85, 627-633 (2006). (Pubitemid 43863036)
7. Dessauer, C. W. Adenylyl cyclasea-kinase anchoring protein complexes: the next dimension in cAMP signaling. Mol. Pharmacol. 76, 935-941 (2009).
8. Zhong, H. et al. Subcellular dynamics of type II PKA in neurons. Neuron 62, 363-374 (2009).
9. Carlucci, A., Lignitto, L. & Feliciello, A. Control of mitochondria dynamics and oxidative metabolism by cAMP, AKAPs and the proteasome. Trends Cell Biol. 18, 604-613 (2008).
10. Tunquist, B. J. et al. Loss of AKAP150 perturbs distinct neuronal processes in mice. Proc. Natl Acad. Sci. USA 105, 12557-12562 (2008).
11. Feliciello, A., Li, Y., Avvedimento, E. V., Gottesman, M. E. & Rubin, C. S. A-kinase anchor protein 75 increases the rate and magnitude of cAMP signaling to the nucleus. Curr. Biol. 7, 1011-1014 (1997). (Pubitemid 28017082)
12. Harada, H. et al. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol. Cell 3, 413-422 (1999). (Pubitemid 29292598)
13. Feliciello, A., Gottesman, M. E. & Avvedimento, E. V. cAMP-PKA signaling to the mitochondria: protein scaffolds, mRNA and phosphatases. Cell Signal. 17, 279-287 (2005). (Pubitemid 39574689)
14. Gomez, L. L., Alam, S., Smith, K. E., Horne, E. & Dell'Acqua, M. L. Regulation of A-kinase anchoring protein 79/150-cAMP-dependent protein kinase postsynaptic targeting by NMDA receptor activation of calcineurin and remodeling of dendritic actin. J. Neurosci. 22, 7027-7044 (2002). (Pubitemid 35379160)
15. Houslay, M. D. Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown. Trends Biochem. Sci. 35, 91-100 (2010).
16. Willoughby, D., Wong, W., Schaack, J., Scott, J. D. & Cooper, D. M. An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics. EMBO J. 25, 2051-2061 (2006).
17. Smith, F. D. et al. AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat. Cell Biol. 12, 1242-1249 (2010).
18. Jurado, S., Biou, V. & Malenka, R. C. A calcineurin/AKAP complex is required for NMDA receptor-dependent long-term depression. Nat. Neurosci. 13, 1053-1055 (2010).
19. Mauban, J. R., O'Donnell, M., Warrier, S., Manni, S. & Bond, M. AKAPscaffolding proteins and regulation of cardiac physiology. Physiology (Bethesda) 24, 78-87 (2009).
20. Bhattacharyya, S., Biou, V., Xu, W., Schluter, O. & Malenka, R. C. A critical role for PSD-95/AKAP interactions in endocytosis of synaptic AMPA receptors. Nat. Neurosci. 12, 172-181 (2009).
21. Lim, C. J. et al. 4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat. Cell Biol. 9, 415-421 (2007). (Pubitemid 46511074)
22. Carlucci, A. et al. Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia. EMBO J. 27, 1073-1084 (2008). (Pubitemid 351508143)
23. Huang, Y. Y. & Kandel, E. R. Recruitment of long-lasting and protein kinase A-dependent long-term potentiation in the CA1 region of hippocampus requires repeated tetanization. Learn. Mem. 1, 74-82 (1994). (Pubitemid 2113963)
24. Chain, D. G. et al. Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron 22, 147-156 (1999). (Pubitemid 29070101)
25. Chain, D. G., Hegde, A. N., Yamamoto, N., Liu-Marsh, B. & Schwartz, J. H. Persistent activation of cAMP-dependent protein kinase by regulated proteolysis suggests a neuron-specic function of the ubiquitin system in Aplysia. J. Neurosci. 15, 7592-7603 (1995).
26. Chain, D. G., Schwartz, J. H. & Hegde, A. N. Ubiquitin-mediated proteolysis in learning and memory. Mol. Neurobiol. 20, 125-142 (1999). (Pubitemid 30637374)
27. Hegde, A. N. et al. Ubiquitin C-terminal hydrolase is an immediate-early gene essential for long-term facilitation in Aplysia. Cell 89, 115-126 (1997). (Pubitemid 27180591)
28. Feliciello, A. et al. The localization and activity of cAMP-dependent protein kinase affect cell cycle progression in thyroid cells. J. Biol. Chem. 275, 303-311 (2000). (Pubitemid 30038986)
29. Yu, P., Chen, Y., Tagle, D. A. & Cai, T. PJA1, encoding a RING-H2nger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain. Genomics 79, 869-874 (2002). (Pubitemid 34595322)
30. Nakayama, M., Miyake, T., Gahara, Y., Ohara, O. & Kitamura, T. A novel RING-H2 motif protein downregulated by axotomy: its characteristic localization at the postsynaptic density of axosomatic synapse. J. Neurosci. 15, 5238-5248 (1995).
31. Rubino, H. M., Dammerman, M., Shat-Zagardo, B. & Erlichman, J. Localization and characterization of the binding site for the regulatory subunit of type II cAMP-dependent protein kinase on MAP2. Neuron 3, 631-638 (1989).
32. Bregman, D. B., Hirsch, A. H. & Rubin, C. S. Molecular characterization of bovine brain P75, a high afnity binding protein for the regulatory subunit of cAMP-dependent protein kinase II. J. Biol. Chem. 266, 7207-7213 (1991). (Pubitemid 21906353)
33. Glantz, S. B., Amat, J. A. & Rubin, C. S. cAMP signaling in neurons: patterns of neuronal expression and intracellular localization for a novel protein, AKAP 150, that anchors the regulatory subunit of cAMP-dependent protein kinase II. Mol. Biol. Cell 3, 1215-1228 (1992). (Pubitemid 23082983)
34. Zhou, Y. et al. Interactions between the NR2B receptor and CaMKII modulate synaptic plasticity and spatial learning. J. Neurosci. 27, 13843-13853 (2007). (Pubitemid 350278268)
35. Michnick, S. W., Ear, P. H., Manderson, E. N., Remy, I. & Stefan, E. Universal strategies in research and drug discovery based on protein-fragment complementation assays. Nat. Rev. Drug Discov. 6, 569-582 (2007). (Pubitemid 47019445)
36. Stefan, E. et al. Quantication of dynamic protein complexes using Renilla luciferase fragment complementation applied to protein kinase A activities in vivo. Proc. Natl Acad. Sci. USA 104, 16916-16921 (2007). (Pubitemid 350210965)
37. Lavoie, C. et al. 1= 2-adrenergic receptor heterodimerization regulates- 2-adrenergic receptor internalization and ERK signaling efcacy. J. Biol. Chem. 277, 35402-35410 (2002).
38. Lonze, B. E. & Ginty, D. D. Function and regulation of CREB family transcription factors in the nervous system. Neuron 35, 605-623 (2002). (Pubitemid 35229980)
39. Montminy, M. Transcriptional regulation by cyclic AMP. Annu. Rev. Biochem. 66, 807-822 (1997). (Pubitemid 27274675)
40. Malleret, G. et al. Bidirectional regulation of hippocampal long-term synaptic plasticity and its inuence on opposing forms of memory. J. Neurosci. 30, 3813-3825 (2010).
41. Armstrong, R., Wen, W., Meinkoth, J., Taylor, S. & Montminy, M. A refractory phase in cyclic AMP-responsive transcription requires down regulation of protein kinase A. Mol. Cell Biol. 15, 1826-1832 (1995).
42. Canettieri, G. et al. Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Nat. Struct. Biol. 10, 175-181 (2003).
43. Houslay, M. D., Baillie, G. S. & Maurice, D. H. cAMP-specic phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling. Circ. Res. 100, 950-966 (2007). (Pubitemid 46598920)
44. Davis, G. W., DiAntonio, A., Petersen, S. A. & Goodman, C. S. Postsynaptic PKA controls quantal size and reveals a retrograde signal that regulates presynaptic transmitter release in Drosophila. Neuron 20, 305-315 (1998). (Pubitemid 28125074)
45. Amieux, P. S. et al. Increased basal cAMP-dependent protein kinase activity inhibits the formation of mesoderm-derived structures in the developing mouse embryo. J. Biol. Chem. 277, 27294-27304 (2002). (Pubitemid 34951748)
46. Newhall, K. J., Cummings, D. E., Nolan, M. A. & McKnight, G. S. Deletion of the RII-subunit of protein kinase A decreases body weight and increases energy expenditure in the obese, leptin-de cient ob/ob mouse. Mol. Endocrinol. 19, 982-991 (2005). (Pubitemid 40397062)
47. Cummings, D. E. et al. Genetically lean mice result from targeted disruption of the RII subunit of protein kinase A. Nature 382, 622-626 (1996). (Pubitemid 26268953)
48. Hegde, A. N., Goldberg, A. L. & Schwartz, J. H. Regulatory subunits of cAMPdependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity. Proc. Natl Acad. Sci. USA 90, 7436-7440 (1993). (Pubitemid 23249964)