A-kinase anchor protein 75 increases the rate and magnitude of cAMP signaling to the nucleus

Current Biology

Volumn 7, Issue 12, 1997, Pages 1011-1014

  Feliciello, Antonio ^a,b   Li, Ying ^a   Awedimento, Enrico V ^c,d   Gottesman, Max E ^b   Rubin, Charles S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d Dipto di Med Sperim e Clinica   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0031441961     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(06)00424-6     Document Type: Article

References (16)

1. Rubin CS: A-kinase anchor proteins and the intracellular targeting of signals carried by cyclic AMP. Biochim Biophys Acta 1994, 1224:467-479.
2. Scott JD, McCartney S: Localization of A-kinase through anchoring proteins. Mol Endocrionol 1994, 8:5-11.
3. Faux MC, Scott JD. Molecular glue: kinase anchoring and scaffold proteins. Cell 1996, 85:9-12.
4. Glantz SB, Arnat JA, Rubin CS: cAMP signaling in neurons: patterns of neuronal expression and intracellular localization for a novel protein, AKAP 150, that anchors the regulatory subunit of cAMP-dependent protein kinase IIβ. Mol Biol Cell 1992, 3:1215-1228.
5. Carr DW, Stofko-Hahn RE, Fraser IDC, Cone RD, Scott JD: Localization of cAMP-dependent protein kinase to postsynaptic densities by a kinase anchoring proteins. J Biol Chem 1992, 267:16816-16823.
6. Ndubuka C, Li Y, Rubin CS: Expression of A-kinase anchor protein 75 depletes type II cAMP-dependent protein kinases from the cytoplasm and sequesters the kinases in a particulate pool. J Biol Chem 1993, 268:7621-7624.
7. Li Y, Ndubuka C, Rubin CS: A-kinase anchor protein 75 targets regulatory (RII) subunits of cAMP-dependent protein kinase II to the cortical actin cytoskeleton in non-neuronal cells. J Biol Chem 1996, 271:16862-16869.
8. Rosenmund C, Carr DW, Bergeson SE, Nilaver G, Scott JD, Westbrook GL: Anchoring of protein kinase A is required for modulation of AMPA/ kainate receptors on hippocampal neurons. Nature 1994, 368:853-856.
9. 2+ channels in skeletal muscle cells requires anchored cAMP-dependent protein kinase. Proc Natl Acad Sci USA 1994, 91:11492-11496.
10. Montminy M. Transcriptional regulation by cyclic AMP. Annu Rev Biochem 1997, 66:807-822.
11. Hirsch AH, Glantz SB, Li Y, You Y, Rubin CS: Cloning and expression of an intronless gene for AKAP75, an anchor protein for the regulatory subunit of cAMP-dependent protein kinase IIβ. J Biol Chem 1992, 267:2131-2134.
12. Glantz SB, Li Y, Rubin CS: Characterization of distinct tethering and intracellular targeting domains in AKAP75, a protein that links cAMP-dependent protein kinase IIβ to the cytoskeleton. J Biol Chem 1993, 268:12796-12804.
13. Feliciello A, Giuliano P, Porcellini A, Garbi C, Obici S, Mele E, et al.: The v-Ki-Ras oncogene alters cAMP nuclear signaling by regulating the location and expression of cAMP-dependent protein kinase IIβ. J Biol Chem 1996, 271:25350-25359.
14. Cassano S, Gallo A, Buccigrossi V, Porcellini A, Cerillo R, Gottesman ME, Awedimento EV: Membrane localization of cAMP-dependent protein kinase amplifies cAMP signaling to the nucleus in PC12 cells. JBiol Chem 1996, 271:29870-29875.
15. Gius D, Cao XM, Rauscher FJ, Cohen DR, Curran T, Sukhatme VP: Transcriptional activation and repression by Fos are independent functions: the C terminus represses immediate-early gene expression via CArG elements. Mol Cell Biol 1990, 10:4243-4255.
16. Montminy MR, Bilezekjian LM: Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature 1987, 328:175-178.