-
1
-
-
84942949401
-
Impotence. NIH Consensus Development Panel on Impotence
-
NIH Consensus Conference.
-
NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993;270:83-90.
-
(1993)
JAMA
, vol.270
, pp. 83-90
-
-
-
2
-
-
0032810944
-
The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences
-
Ayta IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999;84:50-6.
-
(1999)
BJU Int
, vol.84
, pp. 50-56
-
-
Ayta, I.A.1
McKinlay, J.B.2
Krane, R.J.3
-
3
-
-
74049102684
-
Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications
-
Eardley I, Lee JC, Shabsigh R, Dean J, Maggi M, Neuser D, Norenberg C. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med 2010;7(1 Pt 1):244-55.
-
(2010)
J Sex Med
, vol.7
, Issue.1 PART 1
, pp. 244-255
-
-
Eardley, I.1
Lee, J.C.2
Shabsigh, R.3
Dean, J.4
Maggi, M.5
Neuser, D.6
Norenberg, C.7
-
4
-
-
74049143429
-
Pharmacotherapy for erectile dysfunction
-
Eardley I, Donatucci C, Corbin J, El-Meliegy A, Hatzimouratidis K, McVary K, Munarriz R, Lee SW. Pharmacotherapy for erectile dysfunction. J Sex Med 2010;7(1 Pt 2):524-40.
-
(2010)
J Sex Med
, vol.7
, Issue.1 PART 2
, pp. 524-540
-
-
Eardley, I.1
Donatucci, C.2
Corbin, J.3
El-Meliegy, A.4
Hatzimouratidis, K.5
McVary, K.6
Munarriz, R.7
Lee, S.W.8
-
5
-
-
77953573222
-
Efficacy of phosphodiesterase type 5 inhibitor treatment in men with erectile dysfunction and dyslipidemia: A post hoc analysis of the vardenafil statin study
-
Miner MM, Barnes A, Janning S. Efficacy of phosphodiesterase type 5 inhibitor treatment in men with erectile dysfunction and dyslipidemia: A post hoc analysis of the vardenafil statin study. J Sex Med 2010;7:1937-47.
-
(2010)
J Sex Med
, vol.7
, pp. 1937-1947
-
-
Miner, M.M.1
Barnes, A.2
Janning, S.3
-
6
-
-
3342996650
-
Therapeutic strategies for optimizing PDE-5 inhibitor therapy in patients with erectile dysfunction considered difficult or challenging to treat
-
de Tejada IS. Therapeutic strategies for optimizing PDE-5 inhibitor therapy in patients with erectile dysfunction considered difficult or challenging to treat. Int J Impot Res 2004;16(1 suppl):S40-2.
-
(2004)
Int J Impot Res
, vol.16
, Issue.1 SUPPL.
-
-
de Tejada, I.S.1
-
7
-
-
58149520567
-
TNF-alpha knockout mice have increased corpora cavernosa relaxation
-
Carneiro FS, Sturgis LC, Giachini FR, Carneiro ZN, Lima VV, Wynne BM, San Martin S, Brands MW, Tostes RC, Webb RC. TNF-alpha knockout mice have increased corpora cavernosa relaxation. J Sex Med 2009;6:115-25.
-
(2009)
J Sex Med
, vol.6
, pp. 115-125
-
-
Carneiro, F.S.1
Sturgis, L.C.2
Giachini, F.R.3
Carneiro, Z.N.4
Lima, V.V.5
Wynne, B.M.6
San Martin, S.7
Brands, M.W.8
Tostes, R.C.9
Webb, R.C.10
-
8
-
-
0030965669
-
Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries
-
Simonsen U, Prieto D, Hernández M, Sáenz de Tejada I, García-Sacristán A. Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries. J Urol 1997;157:2356-60.
-
(1997)
J Urol
, vol.157
, pp. 2356-2360
-
-
Simonsen, U.1
Prieto, D.2
Hernández, M.3
Sáenz de Tejada, I.4
García-Sacristán, A.5
-
9
-
-
0035126770
-
Combination of phentolamine and L-arginine or sildenafil synergistically improves neurogenic relaxation of rabbit corpus cavernosum smooth muscle
-
Angulo J, Cuevas P, Fernández A, Gabancho S, Saenz de Tejada I. Combination of phentolamine and L-arginine or sildenafil synergistically improves neurogenic relaxation of rabbit corpus cavernosum smooth muscle. Urology 2001;57:585-9.
-
(2001)
Urology
, vol.57
, pp. 585-589
-
-
Angulo, J.1
Cuevas, P.2
Fernández, A.3
Gabancho, S.4
Saenz de Tejada, I.5
-
10
-
-
0030779576
-
Plasma and vascular tissue arginine are decreased in diabetes: Acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production
-
Pieper GM, Dondlinger LA. Plasma and vascular tissue arginine are decreased in diabetes: Acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production. J Pharmacol Exp Ther 1997;283:684-91.
-
(1997)
J Pharmacol Exp Ther
, vol.283
, pp. 684-691
-
-
Pieper, G.M.1
Dondlinger, L.A.2
-
11
-
-
0342784599
-
The effects of long-term oral administration of L-arginine on the erectile response of rabbits with alloxan-induced diabetes
-
Yildirim S, Ayan S, Sarioglu Y, Gultekin Y, Butuner C. The effects of long-term oral administration of L-arginine on the erectile response of rabbits with alloxan-induced diabetes. BJU Int 1999;83:679-85.
-
(1999)
BJU Int
, vol.83
, pp. 679-685
-
-
Yildirim, S.1
Ayan, S.2
Sarioglu, Y.3
Gultekin, Y.4
Butuner, C.5
-
12
-
-
0030742021
-
Effects of long-term oral administration of L-arginine on the rat erectile response
-
Moody JA, Vernet D, Laidlaw S, Rajfer J, Gonzalez-Cadavid NF. Effects of long-term oral administration of L-arginine on the rat erectile response. J Urol 1997;158:942-7.
-
(1997)
J Urol
, vol.158
, pp. 942-947
-
-
Moody, J.A.1
Vernet, D.2
Laidlaw, S.3
Rajfer, J.4
Gonzalez-Cadavid, N.F.5
-
13
-
-
0028386686
-
Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction
-
discussion 36.
-
Zorgniotti AW, Lizza EF. Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction. Int J Impot Res 1994;6:33-5; discussion 36.
-
(1994)
Int J Impot Res
, vol.6
, pp. 33-35
-
-
Zorgniotti, A.W.1
Lizza, E.F.2
-
14
-
-
12244313859
-
Activation and potentiation of the NO/cGMP pathway by NG-hydroxyl-L-arginine in rabbit corpus cavernosum under normoxic and hypoxic conditions and ageing
-
Angulo J, Cuevas P, Fernández A, Gabancho S, Allona A, Martin-Morales A, Moncada I, Sáenz de Tejada I. Activation and potentiation of the NO/cGMP pathway by NG-hydroxyl-L-arginine in rabbit corpus cavernosum under normoxic and hypoxic conditions and ageing. Br J Pharmacol 2003;138:63-70.
-
(2003)
Br J Pharmacol
, vol.138
, pp. 63-70
-
-
Angulo, J.1
Cuevas, P.2
Fernández, A.3
Gabancho, S.4
Allona, A.5
Martin-Morales, A.6
Moncada, I.7
Sáenz de Tejada, I.8
-
15
-
-
0033061065
-
Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats
-
Keegan A, Cotter MA, Cameron NE. Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats. Diabetologia 1999;42:343-50.
-
(1999)
Diabetologia
, vol.42
, pp. 343-350
-
-
Keegan, A.1
Cotter, M.A.2
Cameron, N.E.3
-
16
-
-
0343674062
-
Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse
-
Göçmen C, Seçilmis A, Kumcu EK, Ertug PU, Onder S, Dikmen A, Baysal F. Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse. Eur J Pharmacol 2000;398:93-8.
-
(2000)
Eur J Pharmacol
, vol.398
, pp. 93-98
-
-
Göçmen, C.1
Seçilmis, A.2
Kumcu, E.K.3
Ertug, P.U.4
Onder, S.5
Dikmen, A.6
Baysal, F.7
-
17
-
-
0037167677
-
Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase
-
Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K, Forstermann U. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 2002;106:1652-8.
-
(2002)
Circulation
, vol.106
, pp. 1652-1658
-
-
Wallerath, T.1
Deckert, G.2
Ternes, T.3
Anderson, H.4
Li, H.5
Witte, K.6
Forstermann, U.7
-
18
-
-
19744369830
-
Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats
-
Miatello R, Vázquez M, Renna N, Cruzado M, Zumino AP, Risler N. Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats. Am J Hypertens 2005;18:864-70.
-
(2005)
Am J Hypertens
, vol.18
, pp. 864-870
-
-
Miatello, R.1
Vázquez, M.2
Renna, N.3
Cruzado, M.4
Zumino, A.P.5
Risler, N.6
-
19
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003;425:191-6.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
Lamming, D.W.4
Lavu, S.5
Wood, J.G.6
Zipkin, R.E.7
Chung, P.8
Kisielewski, A.9
Zhang, L.L.10
Scherer, B.11
Sinclair, D.A.12
-
20
-
-
35549008884
-
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase
-
Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, DeRicco J, Kasuno K, Irani K. SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 2007;104:14855-60.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 14855-14860
-
-
Mattagajasingh, I.1
Kim, C.S.2
Naqvi, A.3
Yamamori, T.4
Hoffman, T.A.5
Jung, S.B.6
DeRicco, J.7
Kasuno, K.8
Irani, K.9
-
21
-
-
47949119794
-
Nitric oxide synthesis leads to vascular endothelial growth factor synthesis via the NO/cyclic guanosine 3',5'-monophosphate (cGMP) pathway in human corpus cavernosal smooth muscle cells
-
Komori K, Tsujimura A, Takao T, Matsuoka Y, Miyagawa Y, Takada S, Nonomura N, Okuyama A. Nitric oxide synthesis leads to vascular endothelial growth factor synthesis via the NO/cyclic guanosine 3', 5'-monophosphate (cGMP) pathway in human corpus cavernosal smooth muscle cells. J Sex Med 2008;5:1623-35.
-
(2008)
J Sex Med
, vol.5
, pp. 1623-1635
-
-
Komori, K.1
Tsujimura, A.2
Takao, T.3
Matsuoka, Y.4
Miyagawa, Y.5
Takada, S.6
Nonomura, N.7
Okuyama, A.8
-
22
-
-
0035964782
-
Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor
-
Kim NN, Huang YH, Goldstein I, Bischoff E, Traish AM. Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor. Life Sci 2001;69:2249-56.
-
(2001)
Life Sci
, vol.69
, pp. 2249-2256
-
-
Kim, N.N.1
Huang, Y.H.2
Goldstein, I.3
Bischoff, E.4
Traish, A.M.5
-
23
-
-
0343851651
-
Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells
-
Dulak J, Józkowicz A, Dembinska-Kiec A, Guevara I, Zdzienicka A, Zmudzinska-Grochot D, Florek I, Wójtowicz A, Szuba A, Cooke JP. Nitric oxide induces the synthesis of vascular endothelial growth factor by rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000;20:659-66.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 659-666
-
-
Dulak, J.1
Józkowicz, A.2
Dembinska-Kiec, A.3
Guevara, I.4
Zdzienicka, A.5
Zmudzinska-Grochot, D.6
Florek, I.7
Wójtowicz, A.8
Szuba, A.9
Cooke, J.P.10
-
24
-
-
51649106480
-
Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells
-
Ota H, Eto M, Kano MR, Ogawa S, Iijima K, Akishita M, Ouchi Y. Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler Thromb Vasc Biol 2008;28:1634-9.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1634-1639
-
-
Ota, H.1
Eto, M.2
Kano, M.R.3
Ogawa, S.4
Iijima, K.5
Akishita, M.6
Ouchi, Y.7
-
25
-
-
33750447627
-
Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model
-
Park K, Kim SW, Rhu KS, Paick JS. Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model. J Sex Med 2006;3:996-1003.
-
(2006)
J Sex Med
, vol.3
, pp. 996-1003
-
-
Park, K.1
Kim, S.W.2
Rhu, K.S.3
Paick, J.S.4
-
26
-
-
4644309893
-
Mechanisms of cardiovascular protection by resveratrol
-
Hao HD, He LR. Mechanisms of cardiovascular protection by resveratrol. J Med Food 2004;7:290-8.
-
(2004)
J Med Food
, vol.7
, pp. 290-298
-
-
Hao, H.D.1
He, L.R.2
-
27
-
-
20444444649
-
Mechanism of human SIRT1 activation by resveratrol
-
Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 2005;280:17187-95.
-
(2005)
J Biol Chem
, vol.280
, pp. 17187-17195
-
-
Borra, M.T.1
Smith, B.C.2
Denu, J.M.3
-
28
-
-
0026353632
-
Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
-
Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992;326:90-4.
-
(1992)
N Engl J Med
, vol.326
, pp. 90-94
-
-
Rajfer, J.1
Aronson, W.J.2
Bush, P.A.3
Dorey, F.J.4
Ignarro, L.J.5
-
29
-
-
0035157613
-
The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil
-
Saenz de Tejada I, Angulo J, Cuevas P, Fernández A, Moncada I, Allona A, Lledó E, Körschen HG, Niewöhner U, Haning H, Pages E, Bischoff E. The phosphodiesterase inhibitory selectivity and the in vitro and in vivo potency of the new PDE5 inhibitor vardenafil. Int J Impot Res 2001;13:282-90.
-
(2001)
Int J Impot Res
, vol.13
, pp. 282-290
-
-
Saenz de Tejada, I.1
Angulo, J.2
Cuevas, P.3
Fernández, A.4
Moncada, I.5
Allona, A.6
Lledó, E.7
Körschen, H.G.8
Niewöhner, U.9
Haning, H.10
Pages, E.11
Bischoff, E.12
-
30
-
-
67649364212
-
Vardenafil: Efficacy, tolerability and future directions
-
Rice KR, Dean RC. Vardenafil: Efficacy, tolerability and future directions. Expert Opin Drug Metab Toxicol 2009;5:553-62.
-
(2009)
Expert Opin Drug Metab Toxicol
, vol.5
, pp. 553-562
-
-
Rice, K.R.1
Dean, R.C.2
-
31
-
-
28444442671
-
Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts
-
Huang JS, Chuang LY, Guh JY, Chen CJ, Yang YL, Chiang TA, Hung MY, Liao TN. Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts. J Am Soc Nephrol 2005;16:2318-29.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 2318-2329
-
-
Huang, J.S.1
Chuang, L.Y.2
Guh, J.Y.3
Chen, C.J.4
Yang, Y.L.5
Chiang, T.A.6
Hung, M.Y.7
Liao, T.N.8
-
32
-
-
0043268713
-
Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity
-
Wang S, Wu X, Lincoln TM, Murphy-Ullrich JE. Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity. Diabetes 2003;52:2144-50.
-
(2003)
Diabetes
, vol.52
, pp. 2144-2150
-
-
Wang, S.1
Wu, X.2
Lincoln, T.M.3
Murphy-Ullrich, J.E.4
-
33
-
-
33751294030
-
Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats
-
Moal F, Veal N, Vuillemin E, Barrière E, Wang J, Fizanne L, Oberti F, Douay O, Gallois Y, Bonnefont-Rousselot D, Rousselet MC, Calès P. Hemodynamic and antifibrotic effects of a selective liver nitric oxide donor V-PYRRO/NO in bile duct ligated rats. World J Gastroenterol 2006;12:6639-45.
-
(2006)
World J Gastroenterol
, vol.12
, pp. 6639-6645
-
-
Moal, F.1
Veal, N.2
Vuillemin, E.3
Barrière, E.4
Wang, J.5
Fizanne, L.6
Oberti, F.7
Douay, O.8
Gallois, Y.9
Bonnefont-Rousselot, D.10
Rousselet, M.C.11
Calès, P.12
-
34
-
-
33750242986
-
Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats
-
Masuyama H, Tsuruda T, Kato J, Imamura T, Asada Y, Stasch JP, Kitamura K, Eto T. Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats. Hypertension 2006;48:972-8.
-
(2006)
Hypertension
, vol.48
, pp. 972-978
-
-
Masuyama, H.1
Tsuruda, T.2
Kato, J.3
Imamura, T.4
Asada, Y.5
Stasch, J.P.6
Kitamura, K.7
Eto, T.8
-
35
-
-
61649116241
-
Losartan, an angiotensin type 1 receptor blocker, restores erectile function by down-regulation of cavernous renin-angiotensin system in streptozotocin-induced diabetic rats
-
Yang B, Wen Y, Fand F, Cui S, Lin G, Sun Z, Wang R, Dai Y. Losartan, an angiotensin type 1 receptor blocker, restores erectile function by down-regulation of cavernous renin-angiotensin system in streptozotocin-induced diabetic rats. J Sex Med 2009;6:696-707.
-
(2009)
J Sex Med
, vol.6
, pp. 696-707
-
-
Yang, B.1
Wen, Y.2
Fand, F.3
Cui, S.4
Lin, G.5
Sun, Z.6
Wang, R.7
Dai, Y.8
-
36
-
-
53549106900
-
Role of increased penile expression of transforming growth factor-β1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats
-
Piao S, Choi MJ, Shin H-Y, Jin H-R, Kim WJ, Song SU, Han J-Y, Park SJ, Mamura M, Kim S-J, Ryu J-K, Suh J-K. Role of increased penile expression of transforming growth factor-β1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats. J Sex Med 2008;5:2318-29.
-
(2008)
J Sex Med
, vol.5
, pp. 2318-2329
-
-
Piao, S.1
Choi, M.J.2
Shin, H.-Y.3
Jin, H.-R.4
Kim, W.J.5
Song, S.U.6
Han, J.-Y.7
Park, S.J.8
Mamura, M.9
Kim, S.-J.10
Ryu, J.-K.11
Suh, J.-K.12
|