메뉴 건너뛰기




Volumn 8, Issue 4, 2011, Pages 1061-1071

Vardenafil and Resveratrol Synergistically Enhance the Nitric Oxide/Cyclic Guanosine Monophosphate Pathway in Corpus Cavernosal Smooth Muscle Cells and Its Therapeutic Potential for Erectile Dysfunction in the Streptozotocin-Induced Diabetic Rat: Preliminary Findings

Author keywords

Cyclic GMP; Nitric Oxide; Phosphodiesterase Type 5 Inhibitors; Resveratrol; Vardenafil

Indexed keywords

CYCLIC GMP; NITRIC OXIDE; RESVERATROL; VARDENAFIL;

EID: 79953294297     PISSN: 17436095     EISSN: 17436109     Source Type: Journal    
DOI: 10.1111/j.1743-6109.2010.02193.x     Document Type: Article
Times cited : (42)

References (36)
  • 1
    • 84942949401 scopus 로고
    • Impotence. NIH Consensus Development Panel on Impotence
    • NIH Consensus Conference.
    • NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993;270:83-90.
    • (1993) JAMA , vol.270 , pp. 83-90
  • 2
    • 0032810944 scopus 로고    scopus 로고
    • The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences
    • Ayta IA, McKinlay JB, Krane RJ. The likely worldwide increase in erectile dysfunction between 1995 and 2025 and some possible policy consequences. BJU Int 1999;84:50-6.
    • (1999) BJU Int , vol.84 , pp. 50-56
    • Ayta, I.A.1    McKinlay, J.B.2    Krane, R.J.3
  • 3
    • 74049102684 scopus 로고    scopus 로고
    • Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications
    • Eardley I, Lee JC, Shabsigh R, Dean J, Maggi M, Neuser D, Norenberg C. Vardenafil improves erectile function in men with erectile dysfunction and associated underlying conditions, irrespective of the use of concomitant medications. J Sex Med 2010;7(1 Pt 1):244-55.
    • (2010) J Sex Med , vol.7 , Issue.1 PART 1 , pp. 244-255
    • Eardley, I.1    Lee, J.C.2    Shabsigh, R.3    Dean, J.4    Maggi, M.5    Neuser, D.6    Norenberg, C.7
  • 5
    • 77953573222 scopus 로고    scopus 로고
    • Efficacy of phosphodiesterase type 5 inhibitor treatment in men with erectile dysfunction and dyslipidemia: A post hoc analysis of the vardenafil statin study
    • Miner MM, Barnes A, Janning S. Efficacy of phosphodiesterase type 5 inhibitor treatment in men with erectile dysfunction and dyslipidemia: A post hoc analysis of the vardenafil statin study. J Sex Med 2010;7:1937-47.
    • (2010) J Sex Med , vol.7 , pp. 1937-1947
    • Miner, M.M.1    Barnes, A.2    Janning, S.3
  • 6
    • 3342996650 scopus 로고    scopus 로고
    • Therapeutic strategies for optimizing PDE-5 inhibitor therapy in patients with erectile dysfunction considered difficult or challenging to treat
    • de Tejada IS. Therapeutic strategies for optimizing PDE-5 inhibitor therapy in patients with erectile dysfunction considered difficult or challenging to treat. Int J Impot Res 2004;16(1 suppl):S40-2.
    • (2004) Int J Impot Res , vol.16 , Issue.1 SUPPL.
    • de Tejada, I.S.1
  • 8
    • 0030965669 scopus 로고    scopus 로고
    • Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries
    • Simonsen U, Prieto D, Hernández M, Sáenz de Tejada I, García-Sacristán A. Prejunctional alpha 2-adrenoceptors inhibit nitrergic neurotransmission in horse penile resistance arteries. J Urol 1997;157:2356-60.
    • (1997) J Urol , vol.157 , pp. 2356-2360
    • Simonsen, U.1    Prieto, D.2    Hernández, M.3    Sáenz de Tejada, I.4    García-Sacristán, A.5
  • 9
    • 0035126770 scopus 로고    scopus 로고
    • Combination of phentolamine and L-arginine or sildenafil synergistically improves neurogenic relaxation of rabbit corpus cavernosum smooth muscle
    • Angulo J, Cuevas P, Fernández A, Gabancho S, Saenz de Tejada I. Combination of phentolamine and L-arginine or sildenafil synergistically improves neurogenic relaxation of rabbit corpus cavernosum smooth muscle. Urology 2001;57:585-9.
    • (2001) Urology , vol.57 , pp. 585-589
    • Angulo, J.1    Cuevas, P.2    Fernández, A.3    Gabancho, S.4    Saenz de Tejada, I.5
  • 10
    • 0030779576 scopus 로고    scopus 로고
    • Plasma and vascular tissue arginine are decreased in diabetes: Acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production
    • Pieper GM, Dondlinger LA. Plasma and vascular tissue arginine are decreased in diabetes: Acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production. J Pharmacol Exp Ther 1997;283:684-91.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 684-691
    • Pieper, G.M.1    Dondlinger, L.A.2
  • 11
    • 0342784599 scopus 로고    scopus 로고
    • The effects of long-term oral administration of L-arginine on the erectile response of rabbits with alloxan-induced diabetes
    • Yildirim S, Ayan S, Sarioglu Y, Gultekin Y, Butuner C. The effects of long-term oral administration of L-arginine on the erectile response of rabbits with alloxan-induced diabetes. BJU Int 1999;83:679-85.
    • (1999) BJU Int , vol.83 , pp. 679-685
    • Yildirim, S.1    Ayan, S.2    Sarioglu, Y.3    Gultekin, Y.4    Butuner, C.5
  • 12
    • 0030742021 scopus 로고    scopus 로고
    • Effects of long-term oral administration of L-arginine on the rat erectile response
    • Moody JA, Vernet D, Laidlaw S, Rajfer J, Gonzalez-Cadavid NF. Effects of long-term oral administration of L-arginine on the rat erectile response. J Urol 1997;158:942-7.
    • (1997) J Urol , vol.158 , pp. 942-947
    • Moody, J.A.1    Vernet, D.2    Laidlaw, S.3    Rajfer, J.4    Gonzalez-Cadavid, N.F.5
  • 13
    • 0028386686 scopus 로고
    • Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction
    • discussion 36.
    • Zorgniotti AW, Lizza EF. Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction. Int J Impot Res 1994;6:33-5; discussion 36.
    • (1994) Int J Impot Res , vol.6 , pp. 33-35
    • Zorgniotti, A.W.1    Lizza, E.F.2
  • 14
    • 12244313859 scopus 로고    scopus 로고
    • Activation and potentiation of the NO/cGMP pathway by NG-hydroxyl-L-arginine in rabbit corpus cavernosum under normoxic and hypoxic conditions and ageing
    • Angulo J, Cuevas P, Fernández A, Gabancho S, Allona A, Martin-Morales A, Moncada I, Sáenz de Tejada I. Activation and potentiation of the NO/cGMP pathway by NG-hydroxyl-L-arginine in rabbit corpus cavernosum under normoxic and hypoxic conditions and ageing. Br J Pharmacol 2003;138:63-70.
    • (2003) Br J Pharmacol , vol.138 , pp. 63-70
    • Angulo, J.1    Cuevas, P.2    Fernández, A.3    Gabancho, S.4    Allona, A.5    Martin-Morales, A.6    Moncada, I.7    Sáenz de Tejada, I.8
  • 15
    • 0033061065 scopus 로고    scopus 로고
    • Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats
    • Keegan A, Cotter MA, Cameron NE. Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats. Diabetologia 1999;42:343-50.
    • (1999) Diabetologia , vol.42 , pp. 343-350
    • Keegan, A.1    Cotter, M.A.2    Cameron, N.E.3
  • 16
    • 0343674062 scopus 로고    scopus 로고
    • Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse
    • Göçmen C, Seçilmis A, Kumcu EK, Ertug PU, Onder S, Dikmen A, Baysal F. Effects of vitamin E and sodium selenate on neurogenic and endothelial relaxation of corpus cavernosum in the diabetic mouse. Eur J Pharmacol 2000;398:93-8.
    • (2000) Eur J Pharmacol , vol.398 , pp. 93-98
    • Göçmen, C.1    Seçilmis, A.2    Kumcu, E.K.3    Ertug, P.U.4    Onder, S.5    Dikmen, A.6    Baysal, F.7
  • 17
    • 0037167677 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase
    • Wallerath T, Deckert G, Ternes T, Anderson H, Li H, Witte K, Forstermann U. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 2002;106:1652-8.
    • (2002) Circulation , vol.106 , pp. 1652-1658
    • Wallerath, T.1    Deckert, G.2    Ternes, T.3    Anderson, H.4    Li, H.5    Witte, K.6    Forstermann, U.7
  • 18
    • 19744369830 scopus 로고    scopus 로고
    • Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats
    • Miatello R, Vázquez M, Renna N, Cruzado M, Zumino AP, Risler N. Chronic administration of resveratrol prevents biochemical cardiovascular changes in fructose-fed rats. Am J Hypertens 2005;18:864-70.
    • (2005) Am J Hypertens , vol.18 , pp. 864-870
    • Miatello, R.1    Vázquez, M.2    Renna, N.3    Cruzado, M.4    Zumino, A.P.5    Risler, N.6
  • 21
    • 47949119794 scopus 로고    scopus 로고
    • Nitric oxide synthesis leads to vascular endothelial growth factor synthesis via the NO/cyclic guanosine 3',5'-monophosphate (cGMP) pathway in human corpus cavernosal smooth muscle cells
    • Komori K, Tsujimura A, Takao T, Matsuoka Y, Miyagawa Y, Takada S, Nonomura N, Okuyama A. Nitric oxide synthesis leads to vascular endothelial growth factor synthesis via the NO/cyclic guanosine 3', 5'-monophosphate (cGMP) pathway in human corpus cavernosal smooth muscle cells. J Sex Med 2008;5:1623-35.
    • (2008) J Sex Med , vol.5 , pp. 1623-1635
    • Komori, K.1    Tsujimura, A.2    Takao, T.3    Matsuoka, Y.4    Miyagawa, Y.5    Takada, S.6    Nonomura, N.7    Okuyama, A.8
  • 22
    • 0035964782 scopus 로고    scopus 로고
    • Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor
    • Kim NN, Huang YH, Goldstein I, Bischoff E, Traish AM. Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor. Life Sci 2001;69:2249-56.
    • (2001) Life Sci , vol.69 , pp. 2249-2256
    • Kim, N.N.1    Huang, Y.H.2    Goldstein, I.3    Bischoff, E.4    Traish, A.M.5
  • 24
    • 51649106480 scopus 로고    scopus 로고
    • Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells
    • Ota H, Eto M, Kano MR, Ogawa S, Iijima K, Akishita M, Ouchi Y. Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells. Arterioscler Thromb Vasc Biol 2008;28:1634-9.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1634-1639
    • Ota, H.1    Eto, M.2    Kano, M.R.3    Ogawa, S.4    Iijima, K.5    Akishita, M.6    Ouchi, Y.7
  • 25
    • 33750447627 scopus 로고    scopus 로고
    • Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model
    • Park K, Kim SW, Rhu KS, Paick JS. Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model. J Sex Med 2006;3:996-1003.
    • (2006) J Sex Med , vol.3 , pp. 996-1003
    • Park, K.1    Kim, S.W.2    Rhu, K.S.3    Paick, J.S.4
  • 26
    • 4644309893 scopus 로고    scopus 로고
    • Mechanisms of cardiovascular protection by resveratrol
    • Hao HD, He LR. Mechanisms of cardiovascular protection by resveratrol. J Med Food 2004;7:290-8.
    • (2004) J Med Food , vol.7 , pp. 290-298
    • Hao, H.D.1    He, L.R.2
  • 27
    • 20444444649 scopus 로고    scopus 로고
    • Mechanism of human SIRT1 activation by resveratrol
    • Borra MT, Smith BC, Denu JM. Mechanism of human SIRT1 activation by resveratrol. J Biol Chem 2005;280:17187-95.
    • (2005) J Biol Chem , vol.280 , pp. 17187-17195
    • Borra, M.T.1    Smith, B.C.2    Denu, J.M.3
  • 28
    • 0026353632 scopus 로고
    • Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission
    • Rajfer J, Aronson WJ, Bush PA, Dorey FJ, Ignarro LJ. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med 1992;326:90-4.
    • (1992) N Engl J Med , vol.326 , pp. 90-94
    • Rajfer, J.1    Aronson, W.J.2    Bush, P.A.3    Dorey, F.J.4    Ignarro, L.J.5
  • 30
    • 67649364212 scopus 로고    scopus 로고
    • Vardenafil: Efficacy, tolerability and future directions
    • Rice KR, Dean RC. Vardenafil: Efficacy, tolerability and future directions. Expert Opin Drug Metab Toxicol 2009;5:553-62.
    • (2009) Expert Opin Drug Metab Toxicol , vol.5 , pp. 553-562
    • Rice, K.R.1    Dean, R.C.2
  • 31
    • 28444442671 scopus 로고    scopus 로고
    • Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts
    • Huang JS, Chuang LY, Guh JY, Chen CJ, Yang YL, Chiang TA, Hung MY, Liao TN. Effect of nitric oxide-cGMP-dependent protein kinase activation on advanced glycation end-product-induced proliferation in renal fibroblasts. J Am Soc Nephrol 2005;16:2318-29.
    • (2005) J Am Soc Nephrol , vol.16 , pp. 2318-2329
    • Huang, J.S.1    Chuang, L.Y.2    Guh, J.Y.3    Chen, C.J.4    Yang, Y.L.5    Chiang, T.A.6    Hung, M.Y.7    Liao, T.N.8
  • 32
    • 0043268713 scopus 로고    scopus 로고
    • Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity
    • Wang S, Wu X, Lincoln TM, Murphy-Ullrich JE. Expression of constitutively active cGMP-dependent protein kinase prevents glucose stimulation of thrombospondin 1 expression and TGF-beta activity. Diabetes 2003;52:2144-50.
    • (2003) Diabetes , vol.52 , pp. 2144-2150
    • Wang, S.1    Wu, X.2    Lincoln, T.M.3    Murphy-Ullrich, J.E.4
  • 34
    • 33750242986 scopus 로고    scopus 로고
    • Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats
    • Masuyama H, Tsuruda T, Kato J, Imamura T, Asada Y, Stasch JP, Kitamura K, Eto T. Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats. Hypertension 2006;48:972-8.
    • (2006) Hypertension , vol.48 , pp. 972-978
    • Masuyama, H.1    Tsuruda, T.2    Kato, J.3    Imamura, T.4    Asada, Y.5    Stasch, J.P.6    Kitamura, K.7    Eto, T.8
  • 35
    • 61649116241 scopus 로고    scopus 로고
    • Losartan, an angiotensin type 1 receptor blocker, restores erectile function by down-regulation of cavernous renin-angiotensin system in streptozotocin-induced diabetic rats
    • Yang B, Wen Y, Fand F, Cui S, Lin G, Sun Z, Wang R, Dai Y. Losartan, an angiotensin type 1 receptor blocker, restores erectile function by down-regulation of cavernous renin-angiotensin system in streptozotocin-induced diabetic rats. J Sex Med 2009;6:696-707.
    • (2009) J Sex Med , vol.6 , pp. 696-707
    • Yang, B.1    Wen, Y.2    Fand, F.3    Cui, S.4    Lin, G.5    Sun, Z.6    Wang, R.7    Dai, Y.8
  • 36
    • 53549106900 scopus 로고    scopus 로고
    • Role of increased penile expression of transforming growth factor-β1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats
    • Piao S, Choi MJ, Shin H-Y, Jin H-R, Kim WJ, Song SU, Han J-Y, Park SJ, Mamura M, Kim S-J, Ryu J-K, Suh J-K. Role of increased penile expression of transforming growth factor-β1 and activation of the Smad signaling pathway in erectile dysfunction in streptozotocin-induced diabetic rats. J Sex Med 2008;5:2318-29.
    • (2008) J Sex Med , vol.5 , pp. 2318-2329
    • Piao, S.1    Choi, M.J.2    Shin, H.-Y.3    Jin, H.-R.4    Kim, W.J.5    Song, S.U.6    Han, J.-Y.7    Park, S.J.8    Mamura, M.9    Kim, S.-J.10    Ryu, J.-K.11    Suh, J.-K.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.