Inhibition of cyclic GMP hydrolysis in human corpus cavernosum smooth muscle cells by vardenafil, a novel, selective phosphodiesterase type 5 inhibitor

Life Sciences

Volumn 69, Issue 19, 2001, Pages 2249-2256

  Kim, Noel N ^a   Huang, Yue hua ^a   Goldstein, Irwin ^a   Bischoff, Erwin ^b   Traish, Abdulmaged M ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYER AG   (Germany)

Author keywords

cGMP; Erectile dysfunction; PDE5 inhibitor; Penile cavernosal tissue

Indexed keywords

CELL EXTRACT; CYCLIC GMP; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE V INHIBITOR; SILDENAFIL; UNCLASSIFIED DRUG; VARDENAFIL;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS CAVERNOSUM; DIAGNOSTIC VALUE; DRUG INHIBITION; DRUG SELECTIVITY; ERECTILE DYSFUNCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROLYSIS; IC 50; IN VITRO STUDY; SMOOTH MUSCLE FIBER; SODIUM CELL LEVEL;

CELLS, CULTURED; CYCLIC GMP; HUMANS; HYDROLYSIS; IMIDAZOLES; MALE; MUSCLE, SMOOTH; PENIS; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; SULFONES; TRIAZINES;

EID: 0035964782     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01308-X     Document Type: Article

References (12)

1. Oral sildenafil in the treatment of erectile dysfunction
2. Sildenafil citrate, a selective phosphodiesterase type 5 inhibitor
3. Evaluation of vardenafil, a new highly selective PDE5 inhibitor, in a double-blind, placebo-controlled study in 601 patients with erectile dysfunction
4. Vardenafil, a new PDE5 inhibitor, increases cGMP in rabbit corpus cavernosum
5. Physiology of penile erection
6. Intracellular cyclic GMP receptor proteins
7. Sildenafil: An orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
8. Cyclic nucleotide phosphodiesterase in human cavernous smooth muscle
9. Rabbit corpus cavernosum smooth muscle shows a different phosphodiesterase profile than human corpus cavernosum
10. PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle
11. Sildenafil, a novel inhibitor of phosphodiesterase type 5 in human corpus cavernosum smooth muscle cells
12. The determination of enzyme inhibitor constants