Glucose-induced endoplasmic reticulum stress is independent of oxidative stress: A mechanistic explanation for the failure of antioxidant therapy in diabetes

Free Radical Biology and Medicine

Volumn 50, Issue 9, 2011, Pages 1140-1143

  Mooradian, Arshag D ^a   Haas, Michael J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Antioxidants; Diabetes; Endoplasmic reticulum; Free radicals; Oxidative stress

Indexed keywords

ANTIOXIDANT; GLUCOSE;

ARTICLE; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; ENDOTHELIUM CELL; GENE EXPRESSION; GLUCOTOXICITY; HUMAN; HYPERGLYCEMIA; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; PRIORITY JOURNAL; TOXICITY; TREATMENT FAILURE;

ANIMALS; ANTIOXIDANTS; DIABETES MELLITUS; DRUG THERAPY, COMBINATION; ENDOPLASMIC RETICULUM; ENDOTHELIAL CELLS; GLUCOSE; HUMANS; HYPERGLYCEMIA; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; REACTIVE OXYGEN SPECIES;

EID: 79953253799     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.02.002     Document Type: Article

References (37)

1. M. Sheikh-Ali, J. Chehade, A.D. Mooradian, The antioxidant paradox in diabetes mellitus. Am. J. Ther. (in press).
2. A.D. Mooradian Antioxidants and diabetes Nestle Nutr. Workshop Ser. Clin. Perform. Programme 11 2006 107 122
3. A.C. Maritim, R.A. Sanders, and J.B. Watkins III Diabetes, oxidative stress, and antioxidants: a review J. Biochem. Mol. Toxicol. 17 2003 24 38 (Pubitemid 36410972)
4. G. Bjelakovic, D. Nikolova, L.L. Gluud, R.G. Simonetti, and C. Gluud Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis JAMA 297 2007 842 857 (Pubitemid 46333949)
5. M. Ristow, K. Zarsea, A. Oberbachc, N. Kloting, M. Birringera, M. Kiehntopfd, M. Stumvollc, C.R. Kahne, and M. Bluher Antioxidants prevent health-promoting effects of physical exercise in humans Proc. Natl Acad. Sci. USA 106 2009 8665 8670
6. R. Fürst, S. Zahler, and A.M. Vollmar Dexamethasone-induced expression of endothelial mitogen-activated protein kinase phosphatase-1 involves activation of the transcription factors activator protein-1 and 3′,5′-cyclic adenosine 5′-monophosphate response element-binding protein and the generation of reactive oxygen species Endocrinology 149 2008 3635 3642 (Pubitemid 351919577)
7. A.D. Mooradian Cardiovascular disease in type 2 diabetes mellitus: current management guidelines Arch. Intern. Med. 163 2003 33 40 (Pubitemid 36091598)
8. E.A. Meagher, O.P. Barry, J.A. Lawson, J. Rokach, and G.A. FitzGerald Effects of vitamin E on lipid peroxidation in healthy persons JAMA 285 2001 1178 1182 (Pubitemid 32198483)
9. P. Rosen, P.P. Nawroth, G. King, W. Moller, H.J. Tritschler, and L. Packer The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society Diabetes Metab. Res. Rev. 17 2001 189 212 (Pubitemid 32624602)
10. M. Brownlee Biochemistry and molecular cell biology of diabetic complications Nature 414 2001 813 820 (Pubitemid 34000785)
11. J.L. Evans, I.D. Goldfine, B.A. Maddux, and G.M. Grodsky Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes Endocr. Rev. 23 2002 599 622 (Pubitemid 35191625)
12. T. Nishikawa, D. Edelstein, X.L. Du, S. Yamagishi, T. Matsumura, Y. Kaneda, M.A. Yorek, D. Beebe, P.J. Oates, H.P. Hammes, I. Giardino, and M. Brownlee Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage Nature 404 2000 787 790 (Pubitemid 30212409)
13. E. Araki, S. Oyadomari, and M. Mori Impact of endoplasmic reticulum stress pathway on pancreatic β-cells and diabetes mellitus Exp. Biol. Med. 228 2003 1213 1217 (Pubitemid 37413682)
14. J. Li, J.J. Wang, Q. Yu, M. Wang, and S.X. Zhang Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy FEBS Lett. 583 2009 1521 1527
15. Z.F. Luo, B. Feng, J. Mu, W. Qi, W. Zeng, Y.H. Guo, Q. Pang, Z.L. Ye, L. Liu, and F.H. Yuan Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation Toxicol. Appl. Pharmacol. 246 2010 49 57
16. J. Wu, R. Zhang, M. Torreggiani, A. Ting, H. Xiong, G.E. Striker, H. Vlassara, and F. Zheng Induction of diabetes in aged C57B6 mice results in severe nephropathy: an association with oxidative stress, endoplasmic reticulum stress, and inflammation Am. J. Pathol. 176 2010 2163 2176
17. J.D. Malhotra, and R.J. Kaufman Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxid. Redox Signaling 9 2007 2277 2293 (Pubitemid 350059010)
18. R.R. Kopito Aggresomes, inclusion bodies and protein aggregation Trends Cell Biol. 10 2000 524 530
19. K. Mori Tripartite management of unfolded proteins in the endoplasmic reticulum Cell 101 2000 451 454
20. R.J. Kaufman, D. Scheuner, M. Schroder, X. Shen, K. Lee, C.Y. Liu, and S.M. Arnold The unfolded protein response in nutrient sensing and differentiation Nat. Rev. Mol. Cell Biol. 3 2002 411 421 (Pubitemid 34685699)
21. S. Oyadomari, E. Araki, and M. Mori Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells Apoptosis 7 2002 335 345 (Pubitemid 34832258)
22. P.C. Tsiotra, and C. Tsigos Stress, the endoplasmic reticulum, and insulin resistance Ann. NY Acad. Sci. 1083 2006 63 76 (Pubitemid 44970398)
23. G. Boden, X. Duan, C. Homko, E.J. Molina, W. Song, O. Perez, P. Cheung, and S. Merali Increase in endoplasmic reticulum stress-related proteins and genes in adipose tissue of obese, insulin-resistant individuals Diabetes 57 2008 2438 2444
24. G. Bánhegyi, M. Csala, A. Szarka, M. Varsányi, A. Benedetti, and J. Mandl Role of ascorbate in oxidative protein folding Biofactors 17 2003 37 46 (Pubitemid 37267140)
25. G. Nardai, T. Korcsmáros, E. Papp, and P. Csermely Reduction of the endoplasmic reticulum accompanies the oxidative damage of diabetes mellitus Biofactors 17 2003 259 267 (Pubitemid 37267160)
26. B.P. Tu, and J.S. Weissman Oxidative protein folding in eukaryotes: mechanisms and consequences J. Cell Biol. 164 2004 341 346 (Pubitemid 38174761)
27. M. Sheikh-Ali, S. Sultan, A.R. Alamir, M.J. Haas, and A.D. Mooradian Hyperglycemia-induced endoplasmic reticulum stress in endothelial cells Nutrition 26 2010 1146 1150
28. M. Sheikh-Ali, S. Sultan, A.R. Alamir, M.J. Haas, and A.D. Mooradian Effects of antioxidants on glucose-induced oxidative stress and endoplasmic reticulum stress in endothelial cells Diabetes Res. Clin. Pract. 87 2010 161 166
29. U. Ozcan, E. Yilmaz, L. Ozcan, M. Furuhashi, E. Vaillancourt, R.O. Smith, C.Z. Görgün, and G.S. Hotamisligil Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes Science 313 2006 1137 1140 (Pubitemid 44300242)
30. W.J. Welch, and C.R. Brown Influence of molecular and chemical chaperones on protein folding Cell Stress Chaperones 1 1996 109 115 (Pubitemid 126670772)
31. Q. Xie, V.I. Khaoustov, C.C. Chung, J. Sohn, B. Krishnan, D.E. Lewis, and B. Yoffe Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation Hepatology 36 2002 592 601 (Pubitemid 34977169)
32. M.H. Horani, M.J. Haas, and A.D. Mooradian Rapid adaptive down regulation of oxidative burst induced by high dextrose in human umbilical vein endothelial cells Diabetes Res. Clin. Pract. 66 2004 7 12 (Pubitemid 39201366)
33. C. Weigert, K. Brodbeck, F.C. Brosius III, M. Huber, R. Lehmann, U. Friess, S. Facchin, S. Aulwurm, H.U. Häring, E.D. Schleicher, and C.W. Heilig Evidence for a novel TGF-beta1-independent mechanism of fibronectin production in mesangial cells overexpressing glucose transporters Diabetes 52 2003 527 535 (Pubitemid 36173213)
34. J.A. Herlein, B.D. Fink, Y. O'Malley, and W.I. Sivitz Superoxide and respiratory coupling in mitochondria of insulin-deficient diabetic rats Endocrinology 150 2009 46 55
35. L.P. Aiello, and J.S. Wong Role of vascular endothelial growth factor in diabetic vascular complications Kidney Int. Suppl. 77 2000 S113 S119
36. A. Flyvbjerg Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease Diabetologia 43 2000 1205 1223
37. M.J. Haas, M.H. Horani, S.A. Parseghian, and A.D. Mooradian Statins prevent dextrose-induced endothelial barrier dysfunction, possibly through inhibition of superoxide formation Diabetes 55 2006 474 479 (Pubitemid 43343278)