A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 7, 2008, Pages 2556-2561

  Couzinet, Arnaud ^a   Tamura, Kaoru ^a,b   Chen, Hui Min ^a,c   Nishimura, Keishiro ^a   Wang, ZhiChao ^a   Morishita, Yasuyuki ^a   Takeda, Kazuyoshi ^d   Yagita, Hideo ^d   Yanai, Hideyuki ^a   Taniguchi, Tadatsugu ^a   Tamura, Tomohiko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^d JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Death receptor; Dendritic cell; Liver; Programmed cell death; Transcription factor

Indexed keywords

CASPASE 8; FAS ANTIBODY; INTERFERON REGULATORY FACTOR 5; MONOCLONAL ANTIBODY; STRESS ACTIVATED PROTEIN KINASE; CASPASE; FAS ANTIGEN; INTERFERON REGULATORY FACTOR; IRF5 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL TYPE; CONTROLLED STUDY; DENDRITIC CELL; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; FIBROBLAST; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; THYMOCYTE; ANIMAL; C57BL MOUSE; DOWN REGULATION; GENETICS; LIVER; METABOLISM; MOUSE MUTANT; SENSITIVITY AND SPECIFICITY;

MUS;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; CASPASES; DOWN-REGULATION; ENZYME ACTIVATION; INTERFERON REGULATORY FACTORS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; SENSITIVITY AND SPECIFICITY;

EID: 40649086198     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0712295105     Document Type: Article

References (31)

1. Takaoka A, et al. (2005) Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature 434:243-249.
2. Barnes BJ, Moore PA, Pitha PM (2001) Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes. J Biol Chem 276:23382-23390.
3. Yanai H, et al. (2007) Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci USA 104:3402-3407.
4. Barnes BJ, Kellum MJ, Field AE, Pitha PM (2002) Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes. Mol Cell Biol 22:5721-5740.
5. Mori T, Anazawa Y, Iiizumi M, Fukuda S, Nakamura Y, Arakawa H (2002) Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53. Oncogene 21:2914-2918.
6. Barnes BJ, Kellum MJ, Pinder KE, Frisancho JA, Pitha PM (2003) Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death. Cancer Res 63:6424-6431.
7. Hu G, Mancl ME, Barnes BJ (2005) Signaling through IFN regulatory factor-5 sensitizes p53-deficient tumors to DNA damage-induced apoptosis and cell death. Cancer Res 65:7403-7412.
8. Nagata S (1999) Fas ligand-induced apoptosis. Annu Rev Genet 33:29-55.
9. Peter ME, Krammer PH (2003) The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ 10:26-35.
10. Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T, Vandenabeele P (2007) Caspases in cell survival, proliferation and differentiation. Cell Death Differ 14:44-55.
11. Yin XM, et al. (1999) Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400:886-891.
12. Barnhart BC, Alappat EC, Peter ME (2003) The CD95 type I/type II model. Semin Immunol 15:185-193.
13. Weaver BK, Ando O, Kumar KP, Reich NC (2001) Apoptosis is promoted by the dsRNA-activated factor (DRAF1) during viral infection independent of the action of interferon or p53. FASEB J 15:501-515.
14. Stranges PB, et al. (2007) Elimination of antigen-presenting cells and autoreactive T cells by Fas contributes to prevention of autoimmunity. Immunity 26:629-641.
15. Chen M, Huang L, Wang J (2007) Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. Blood 109:4360-4367.
16. Krieg AM, et al. (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546-549.
17. Chang L, et al. (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFα-induced cell death by inducing c-FLIP(L) turnover. Cell 124:601-613.
18. Angel P, Hattori K, Smeal T, Karin M (1988) The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 55:875-885.
19. Harris CA, Johnson EM, Jr (2001) BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons. J Biol Chem 276:37754-37760.
20. Whitfield J, Neame SJ, Paquet L, Bernard O, Ham J (2001) Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29:629-643.
21. Park SM, Schickel R, Peter ME (2005) Nonapoptotic functions of FADD-binding death receptors and their signaling molecules. Curr Opin Cell Biol 17:610-616.
22. Peter ME, et al. (2007) The CD95 receptor: Apoptosis revisited. Cell 129:447-450.
23. Putcha GV, et al. (2003) JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38:899-914.
24. EL triggers a positive feedback amplification of apoptotic signaling. Proc Natl Acad Sci USA 101:1235-1240.
25. Corazza N, et al. (2006) TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. J Clin Invest 116:2493-2499.
26. Costelli P, et al. (2003) Mice lacking TNFα receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody. Cell Death Differ 10:997-1004.
27. Ichijo H, et al. (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275:90-94.
28. Matsuki Y, et al. (2002) Soluble Fas gene therapy protects against Fas-mediated apoptosis of hepatocytes but not the lethal effects of Fas-induced TNF-α production by Kupffer cells. Cell Death Differ 9:626-635.
29. Sato M, et al. (2000) Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-α/β gene induction. Immunity 13:539-548.
30. Lutz MB, et al. (1999) An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 223:77-92.
31. Hueber AO, Bernard AM, Herincs Z, Couzinet A, He HT (2002) An essential role for membranerafts in the initiation of Fas/CD95-triggered cell death in mouse thymocytes. EMBO Rep 3:190-196.