Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major

Journal of Biological Chemistry

Volumn 286, Issue 12, 2011, Pages 10429-10438

  Ong, Han B ^a   Sienkiewicz, Natasha ^a   Wyllie, Susan ^a   Fairlamb, Alan H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN TRYPANOSOMES; BIOPTERIN; DRUG TARGETS; DUAL ROLE; ENZYME ASSAYS; INTRACELLULAR POOL; KINETIC PROPERTIES; KNOCK OUTS; LEISHMANIA; LEISHMANIA MAJOR; METABOLIC ROLES; PHYSIOLOGICAL PH; TETRAHYDROBIOPTERIN; TRYPANOSOMA BRUCEI;

GENES; IONIC STRENGTH; LAKES; METABOLISM; PH;

ENZYME ACTIVITY;

BIOPTERIN; DIHYDROPTERIDINE REDUCTASE; MICROBIAL ENZYME; PTERIDINE REDUCTASE 1 ENZYME; PTERIN DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CELL PH; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME METABOLISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; GENE OVEREXPRESSION; IONIC STRENGTH; LEISHMANIA MAJOR; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

ANIMALS; DIHYDROPTERIDINE REDUCTASE; GENE KNOCKDOWN TECHNIQUES; HYDROGEN-ION CONCENTRATION; KINETICS; LEISHMANIA MAJOR; OXIDOREDUCTASES; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; TRYPANOSOMA CRUZI;

LEISHMANIA MAJOR; RATTUS; TRYPANOSOMA BRUCEI;

EID: 79953218012     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.209593     Document Type: Article

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