Design, synthesis, and hypnotic activity of pyrazolo[1,5-a]pyrimidine derivatives

Chinese Chemical Letters

Volumn 15, Issue 8, 2004, Pages 885-888

  Wang, Song Qing ^a   Fang, Lin ^a   Liu, Xiu Jie ^a   Zhao, Kang ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b TIANJIN UNIVERSITY   (China)

Author keywords

GABA; Hypnotic drug; Pyrazolo 1,5 a pyrimidines; Synthesis

Indexed keywords

5 METHYL 7 N,N DIPHENYLMETHYLAMINOPYRAZOLO[1,5 A]PYRIMIDINE 3 CARBONITRILE; FORMIC ACID DERIVATIVE; HYPNOTIC AGENT; NITRILE; PROPANE; PROPANE DINITRILE; PYRAZOLE DERIVATIVE; PYRIMIDINE DERIVATIVE; TRIETHYL ORTHOFORMATE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 4444342110     PISSN: 10018417     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. C. F. P. George. The Lancet, 2001, 358, 1623.
2. D. Drover, H. Lemmens, S. Naidu, et al., Clinical Therapeutics, 2000, 2212, 1443.
3. B. Joachim. TIOS, 2000, 21, 16.
4. T. A. D Smith. British J. of Biomedical Science, 2001, 58(2), 111.
5. K. R. Roland. J. Am. Chem. Soc., 1956, 78(4), 784.
6. W. Huber. J. Am. Chem. Soc., 1943, 65(3), 2224.
7. A. A. Mnolzhoyan, A. A. Aroyan. Lzv. Akad. Nauk. Armyan. S. S. R. Ser. Khim Nauk., 1957, 10, 203.
8. Compared drug: Zaleplon was obtained from Batch Pharmaceutical Co, USA, 010118; Positive control drug: Estazolam was obtained from Tianjin Haiguang Pharmaceutical factory, 2 mg/Kg.