Pituitary Tumor Pathogenesis

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 6, 1997, Pages 1675-1681

  Shimon, Ilan ^a   Melmed, Shlomo ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACE RECEPTOR; FGF4 PROTEIN, HUMAN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 4; GROWTH PROMOTOR; ONCOPROTEIN;

ENDOCRINE DISEASE; GENETICS; HUMAN; HYPOPHYSIS TUMOR; MUTATION; PHYSIOLOGY; REVIEW; TUMOR SUPPRESSOR GENE;

ENDOCRINE SYSTEM DISEASES; FIBROBLAST GROWTH FACTOR 4; FIBROBLAST GROWTH FACTORS; GENES, TUMOR SUPPRESSOR; GROWTH SUBSTANCES; HUMANS; MUTATION; PITUITARY NEOPLASMS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE;

EID: 0031158860     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.6.1675     Document Type: Article

References (104)

1. Billestrup N, Swanson LW, Vale W. 1986 Growth hormone-releasing factor stimulates proliferation of somatotrophs in vitro. Proc Natl Acad Sci USA. 83:6854-6857.
2. Sano T, Asa SL, Kovacs K. 1988 Growth hormone-releasing hormone-producing tumors: clinical, biochemical, and morphological manifestations. Endocr Rev. 9:357-373.
3. Asa SL, Kovacs K, Tindall GT, Barrow DL, Horvath E, Vecsei P. 1984 Cushing's disease associated with an intrasellar gangliocytoma producing corticotropin-releasing factor. Ann Intern Med. 101:789-793.
4. Carey RM, Varma SK, Drake Jr CR, et al. 1984 Ectopic secretion of corticotropin-releasing factor as a cause of Cushing's syndrome. N Engl J Med. 311:13-20.
5. Molitch M. 1987 Pathogenesis of pituitary tumors. Endocrinol Metab Clin. 16:503-527.
6. Vogelstein B, Fearon ER, Hamilton SR, et al. 1987 Clonal analysis using recombinant DNA probes for the x-chromosome. Cancer Res. 47:4806-4813.
7. Alexander JM, Biller BMK, Bikkal H, Zervas NT, Arnold A, Klibanski A. 1990 Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest. 86:336-340.
8. Herman V, Fagin J, Gonsky R, Kovacs K, Melmed S. 1990 Clonal origin of pituitary adenomas. J Clin Endocrinol Metab. 71:1427-1433.
9. Schulte HM, Oldfield EH, Allolio B, Katz DA, Berkman RA, Ali IU. 1991 Clonal composition of pituitary adenomas in patients with Cushing's disease: determination by X-chromosome inactivation analysis. J Clin Endocrinol Metab. 73:1302-1308.
10. Biller BMK, Alexander JM, Zervas NT, Hedley-Whyte ET, Arnold A, Klibanski A. 1992 Clonal origins of adrenocorticotrpin-secreting pituitary tissue in Cushing's disease. J Clin Endocrinol Metab. 75:1303-1309.
11. Gicquel C, Le Bouc Y, Luton J-P, Girard F, Bertagna X. 1992 Monoclonality of corticotroph macroadenomas in Cushing's disease. J Clin Endocrinol Metab. 75:472-475.
12. Molitch ME. 1995 Prolactinoma. In: Melmed S, ed. The pituitary. Cambridge: Blackwell; 443-477.
13. Ezzat S, Snyder PJ, Young WF, et al. 1992 Octreotide treatment of acromegaly: a randomized, multicenter study. Ann Intern Med. 117:711-718.
14. Nelson DH, Meakin JW, Thorn GW. 1960 ACTH-producing pituitary tumors following adrenalectomy for Cushing's syndrome. Ann Intern Med. 52:560-569.
15. Strader CD, Ming Fong T, Tota MR, Underwood D. 1994 Structure and function of G protein-coupled receptors. Annu Rev Biochem. 63:101-132.
16. Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. 1989 GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature. 340:692-696.
17. s protein α subunit-gsp oncogene is found in human pituitary tumours. Oncogene. 5:1059-1061.
18. Lyons J, Landis CA, Harsh G, et al. 1990 Two G protein oncogenes in human endocrine tumors. Science. 249:655-659.
19. Boggild MD, Jenkinson S, Pistorello M, et al. 1994 Molecular genetic studies of sporadic pituitary tumors. J Clin Endocrinol Metab. 78:387-392.
20. s α in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues. Acta Endocrinol (Copenh). 129:301-306.
21. s and adenylate cyclase activity in human GH-secreting pituitary adenomas. Nature. 330:566-568.
22. s protein. J Clin Endocrinol Metab. 71:1416-1420.
23. Spada A, Arosio M, Bochicchio D, et al. 1990 Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J Clin Endocrinol Metab. 71:1421-1426.
24. Spada A, Vallar L, Faglia G. 1992 G protein oncogenes in pituitary tumors. Trends Endocrinol Metab. 3:355-360.
25. Spada A, Vallar L, Faglia G. 1994 Cellular alterations in pituitary tumors. Eur J Endocrinol. 130:43-52.
26. Weinstein LS, Shenker A, Gejman PV, Merino MJ, Friedman E, Spiegel AM. 1991 Activating mutations of the stimulatory G protein in the McCune-Albright syndrome. N Engl J Med. 325:1688-1695.
27. Schwindinger WF, Francomano CA, Levine MA. 1992 Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G-protein of adenylyl cyclase in McCune-Albright syndrome. Proc Natl Acad Sci USA. 89:5152-5156.
28. s α mutation at codon 201 in pituitary adenoma causing gigantism in a 6-year-old boy with McCune-Albright syndrome. J Clin Endocrinol Metab. 81:3839-3842.
29. s α-gene in nonfunctioning pituitary tumors. J Clin Endocrinol Metab. 77:765-769.
30. i2α mutations in clinically non-functioning pituitary tumours. Clin Endocrinol (Oxf). 41:815-820.
31. Dong Q, Brucker-Davis F, Weintraub BD, et al. 1996 Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the Gαq, Gα11, Gαs, or thyrotropin-releasing hormone receptor genes. J Clin Endocrinol Metab. 81:1134-1140.
32. Williamson EA, Ince PG, Harrison D, Kendall-Taylor P, Harris PE. 1995 G-Protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas. Eur J Clin Invest. 25:128-131.
33. Struthers RS, Vale WW, Arias C, Sawchenko PE, Montminy MR. 1991 Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant. Nature. 350:622-624.
34. Bertherat J, Chanson P, Montminy M. 1995 The cyclic adenosine 3′,5′-monophosphate-responsive factor CREB is constitutively activated in human somatotroph adenomas. Mol Endocrinol. 9:777-783.
35. Lochrie MA, Hurley JB, Simon MI. 1985 Sequence of the alpha subunit of photoreceptor G protein: homologies between transducin, ras, and elongation factors. Science. 228:96-99.
36. Bos JL. 1989 ras oncogenes in human cancer: a review. Cancer Res. 49:4682-4689.
37. Namba H, Rubin SA, Fagin JA. 1990 Point mutations of ras oncogenes are an early event in thyroid tumorigenesis. Mol Endocrinol. 4:1474-1479.
38. Karga HJ, Alexander JM, Hedley-Whyte ET, Klibansky A, Jameson JL. 1992 ras mutations in human pituitary tumors. J Clin Endocrinol Metab. 74:914-919.
39. Herman V, Drazin NZ, Gonsky R, Melmed S. 1993 Molecular screening of pituitary adenomas for gene mutations and rearrangements. J Clin Endocrinol Metab. 77:50-55.
40. Cai WY, Alexander JM, Hedley-Whyte ET, et al. 1994 ras mutations in human prolactinomas and pituitary carcinomas. J Clin Endocrinol Metab. 78:89-93.
41. Fei L, Melmed S, Scheithauer B, Kovacs K, Prager D. 1994 H-ras mutations in human pituitary carcinoma metastasis. J Clin Endocrinol Metab. 78:842-846.
42. Hollstein M, Sidransky D, Vogelstein B, Harris CC. 1991 p53 mutations in human cancers. Science. 253:49-53.
43. Levy A, Hall L, Yeudall WA, Lightman SL. 1994 p53 gene mutations in pituitary adenomas: rare events. Clin Endocrinol (Oxf). 41:809-814.
44. Larsson C, Skogseid B, Oberg K, Nakamura Y, Nordenskjold M. 1988 Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature. 322:85-87.
45. Fujimori M, Wells SA, Nakamura Y. 1992 Fine mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN1). Am J Hum Genet. 55:399-403.
46. Friedman E, Sakaguchi K, Bale AE, et al. 1989 Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1. N Engl J Med. 321:213-218.
47. Thakker RV, Bouloux P, Wooding C, et al. 1989 Association of parathyroid tumors in multiple endocrine neoplasia 1 with loss of alleles on chromosome 11. N Engl J Med. 321:218-224.
48. Bystrom C, Larrson C, Blomberg C, et al. 1990 Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors. Proc Natl Acad Sci USA. 87:1968-1972.
49. Bale AE, Norton JA, Wong EL, et al. 1991 Allelic loss on chromosome 11 in hereditary and sporadic tumors related to familial multiple endocrine neoplasia type 1. Cancer Res. 51:1154-1157.
50. Jakobovitz O, Nass D, DeMarco L, et al. 1996 Carcinoid tumors frequently display genetic abnormalities involving chromosome 11. J Clin Endocrinol Metab. 81:3164-3167.
51. Beckers A, Abs R, Reyniers E, et al. 1994 Variable regions of chromosome 11 loss in different pathological tissues of a patient with the multiple endocrine neoplasia type 1 syndrome. J Clin Endocrinol Metab. 79:1498-1502.
52. Thakker RV, Pook MA, Wooding C, Boscaro M, Scanarini M, Clayton RN. 1993 Association of somatotrophinomas with loss of alleles on chromosome 11 and with gsp mutations. J Clin Invest. 91:2815-2821.
53. Eubanks PJ, Sawicki MP, Samara GJ, et al. 1994 Putative tumor-suppressor gene on chromosome 11 is important in sporadic endocrine tumor formation. Am J Surg. 167:180-185.
54. Knudson AGJ. 1971 Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA. 68:820-823.
55. Friend SH, Bernards R, Rogelj S, et al. 1986 A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature. 323:643-646.
56. Lee EY-HP, To H, Shew JY, Brookstein R, Scully P, Lee WH. 1988 Inactivation of the retinoblastoma susceptibility gene in human breast carcinoma. Science. 241:218-221.
57. Jacks T, Fazeli A, Schmitt EM, Bronson RT, Goodell MA, Weinberg RA. 1992 Effects of an RB mutation in the mouse. Nature. 359:295-300.
58. + mice are predisposed to tumors of the pituitary gland with a nearly complete penetrance. Oncogene. 9:1021-1027.
59. Cryns VL, Alexander JM, Klibanski A, Arnold A. 1993 The retinoblastoma gene in human pituitary tumors. J Clin Endocrinol Metab. 77:644-646.
60. Zhu J, Leon SP, Beggs AH, Busque L, Gilliliard DG, Black PM. 1994 Human pituitary adenomas show no loss of heterozygosity at the retinoblastoma gene locus. J Clin Endocrinol Metab. 78:922-927.
61. Woloschak M, Roberts JL, Post KD. 1994 Loss of heterozygosity at the retinoblastoma locus in human pituitary tumors. Cancer. 74:693-696.
62. Woloschak M, Yu A, Xiao J, Post KD. 1996 Abundance and state of phosphorylation of the Rb gene product in human pituitary tumors. Int J Cancer. 67:16-19.
63. Pei L, Melmed S, Scheithauer B, Kovacs K, Benedict WF, Prager D. 1995 Frequent loss of heterozygosity at the retinoblastoma susceptibility gene (RB) locus in aggressive pituitary tumors: evidence for a chromosome 13 tumor suppressor gene other than RB. Cancer Res. 55:1613-1616.
64. Bevilaqua G, Sobel ME, Liotta LA, Steeg PS. 1989 Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymphnode involvement and other histopathological indicators of high metastatic potential. Cancer Res. 49:5185-5190.
65. Takino H, Herman V, Weiss M, Melmed S. 1995 Purine-binding factor (nm23) gene expression in pituitary tumors: marker of adenoma invasiveness. J Clin Endocrinol Metab. 80:1733-1738.
66. Weinberg RA. 1995 The retinoblastoma protein and cell cycle control. Cell. 81:323-330.
67. Woloschak M, Yu A, Xiao J, Post KD. 1996 Frequent loss of the p16ink4a in human pituitary tumors. Cancer Res. 56:2493-2496.
68. Kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors. Cell. 85:707-720.
69. Kip1. Cell. 85:721-732.
70. Kip1-deficient mice. Cell. 85:733-744.
71. Herman-Bonert VS, Prager D, Melmed S. 1995 Growth hormone. In: Melmed S, ed. The pituitary. Cambridge: Blackwell; 98-135.
72. Lin SC, Lin CR, Gukovsky I, Lusis AJ, Sawchenko PE, Rosenfeld MG. 1993 Molecular basis of the little mouse phenotype and implications for cell type-specific growth. Nature. 364:208-213.
73. Hashimoto K, Koga M, Motomura T, et al. 1995 Identification of alternatively spliced messenger ribonucleic acid encoding truncated growth hormone-releasing hormone receptor in human pituitary adenomas. J Clin Endocrinol Metab. 80:2933-2939.
74. Greenman Y, Prager D, Melmed S. 1995 The ICF-I receptor sub-membrane domain is intact in GH-secreting pituitary tumours. Clin Endocrinol (Oxf). 42:169-172.
75. Greenman Y, Melmed S. 1994 Heterogeneous expression of two somatostatin receptor subtypes in pituitary tumors. J Clin Endocrinol Metab. 78:398-403.
76. Greenman Y, Melmed S. 1994 Expression of three somatostatin receptor subtypes in pituitary adenomas: evidence for preferential SSTR5 expression in the mammosomatotroph lineage. J Clin Endocrinol Metab. 79:724-729.
77. Shimon I, Taylor JE, Dong J, et al. 1997 Somatostatin receptor subtype specificity in human fetal pituitary cultures: differential role of SSTR2 and SSTR5 for growth hormone, thyroid-stimulating hormone and prolactin regulation. J Clin Invest. 99:789-798.
78. Faccenda E, Melmed S, Bevan JS, Eidne KA. 1996 Structure of the thyrotrophin-releasing hormone receptor in human pituitary adenomas. Clin Endocrinol (Oxf). 44:341-347.
79. Friedman E, Adams EF, Hoog A, et al. 1994 Normal structural dopamine type 2 receptor gene in prolactin-secreting and other pituitary tumors. J Clin Endocrinol Metab. 78:568-574.
80. Mason IJ. 1994 The ins and outs of fibroblast growth factors. Cell. 78:547-552.
81. Gospodarowicz D, Ferrara N, Schweigerer L, Neufeld G. 1987 Structural characterization and biological functions of fibroblast growth dactor. Endocr Rev. 8:95-114.
82. Gospodarowicz D, Neufeld G, Schweigeier L. 1986 Fibroblast growth factor. Mol Cell Endocrinol. 46:187-204.
83. Bohlen P, Baird A, Esch F, Ling N, Gospodarowicz D. 1984 Isolation and partial molecular characterization of pituitary fibroblast growth factor. Proc Natl Acad Sci USA. 81:5364-5368.
84. Baird A, Mormede P, Ying SY, et al. 1985 A nonmitogenic pituitary function of fibroblast growth factor: regulation of thyrotropin and prolactin secretion. Proc Natl Acad Sci USA. 82:5545-5549.
85. Atkin SL, Landolt AM, Jeffreys RV, Diver M, Radcliffe J, White MC. 1993 Basic fibroblast growth factor stimulates prolactin secretion from human anterior pituitary adenomas without affecting adenoma cell proliferation. J Clin Endocrinol Metab. 77:831-837.
86. Li Y, Koga M, Kasayama S, et al. 1992 Identification and characterization of high molecular weight forms of basic fibroblast growth factor in human pituitary adenomas. J Clin Endocrinol Metab. 75:1436-1441.
87. Ezzat S, Smyth HS, Ramyar L, Asa SL. 1995 Heterogenous in vivo and in vitro expression of basic fibroblast growth factor by human pituitary adenomas. J Clin Endocrinol Metab. 80:878-884.
88. Weiner RI, Windle J, Mellon P, Schechter J. 1991 Role of FGF in tumorigenesis of the anterior pituitary [Abstract]. J. Endocrinol Invest. 14(Suppl 1):10.
89. Zimering MB, Brandi ML, deGrange DA, et al. 1990 Circulating fibroblast growth factor-like substance in familial multiple endocrine neoplasia type 1. J Clin Endocrinol Metab. 70:149-154.
90. Zimering MB, Katsumata N, Sato Y, et al. 1993 Increased basic fibroblast growth factor in plasma from multiple endocrine neoplasia type 1: relation to pituitary tumor. J Clin Endocrinol Metab. 76:1182-1187.
91. Zimering MB, Riley DJ, Thakker-Varia S, et al. 1994 Circulating fibroblast growth factor-like autoantibodies in two patients with multiple endocrine neoplasia type 1 and prolactinoma. J Clin Endocrinol Metab. 79:1546-1552.
92. Sakamoto H, Mori M, Taira M, et al. 1986 Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa. Proc Natl Acad Sci USA. 83:3997-4001.
93. Yoshida MC, Wada M, Satoh H, et al. 1988 Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer. Proc Natl Acad Sci USA. 85:4861-4864.
94. Shimon I, Huttner A, Said J, Spirina O, Melmed S. 1996 Heparin-binding secretory transforming gene (list) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription. J Clin Invest. 97:187-195.
95. Gonsky R, Herman V, Melmed S, Fagin J. 1991 Transforming DNA sequences present in human prolactin secreting pituitary tumors. Mol Endocrinol. 5:1687-1695.
96. Derynck R, Goeddel DV, Ullrich A, et al. 1987 Synthesis of messenger RNAs for transforming growth factors α and β and the epidermal growth factor receptor by human tumors. Cancer Res. 47:707-712.
97. Samsoondar J, Korbin MS, Kudlow JE. 1986 α-Transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. I. Purification from conditioned media. J Biol Chem. 261:14408-14413.
98. Korbin MS, Samsoondar J, Kudlow JE. 1986 α-Transforming growth factor secreted by untransformed bovine anterior pituitary cells in culture. II. Identification using a sequence-specific monoclonal antibody. J Biol Chem. 261:14414-14419.
99. Korbin MS, Asa SL, Samsoondar J, Kudlow JE. 1987 α-Transforming growth factor in the bovine anterior pituitary gland: secretion by dispersed cells and immunohistochemical localization. Endocrinology. 121:1412-1416.
100. Mueller SG, Korbin MS, Paterson AJ, Kudlow JE. 1989 Transforming growth factor-α expression in the anterior pituitary gland: regulation by epidermal growth factor and phorbol ester in dispersed cells. Mol Endocrinol. 3:976-983.
101. Driman DK, Korbin MS, Kudlow JE, Asa SL. 1992 Transforming growth factor-α in normal and neoplastic human endocrine tissues. Hum Pathol. 23:1360-1365.
102. Ezzat S, Walpola IA, Ramyar L, Smyth HS, Asa SL. 1995 Membrane-anchored expression of transforming growth factor-α in human pituitary adenoma cells. J Clin Endocrinol Metab. 80:534-539.
103. McAndrew J, Paterson AJ, Asa SL, McCarthy KJ, Kudlow JE. 1995 Targeting of transforming growth factor-a expression to pituitary lactotrophs in transgenic mice results in selective lactotroph proliferation and adenomas. Endocrinology. 136:4479-4488.
104. Pei L, Melmed S. Isolation and characterization of a pituitary tumor-specific transforming gene. Mol Endocrinol. 11:433-441.