Augmented oxygen-mediated transcriptional activation of cytochrome P450 (CYP)1A expression and increased susceptibilities to hyperoxic lung injury in transgenic mice carrying the human CYP1A1 or mouse 1A2 promoter in vivo

Biochemical and Biophysical Research Communications

Volumn 407, Issue 1, 2011, Pages 79-85

  Jiang, Weiwu ^a   Couroucli, Xanthi I ^a   Wang, Lihua ^a   Barrios, Roberto ^b   Moorthy, Bhagavatula ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

CYP1A2; Cytochrome P4501A1; Gene regulation; Hyperoxia; In vivo; Luciferase reporter; Lung injury; Mice; Promoter; Transgenic mice

Indexed keywords

CYTOCHROME P450 1A; CYTOCHROME P450 1A2; LUCIFERASE; OXYGEN;

ADULT; AMBIENT AIR; ANIMAL EXPERIMENT; ARTICLE; BIOLUMINESCENCE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ELECTROPHORESIS; ENZYME ACTIVITY; EXPOSURE; HUMAN; HYPEROXIA; HYPOTHESIS; IMAGING; LUNG INJURY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ACUTE LUNG INJURY; ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; GENES, REPORTER; HUMANS; HYPEROXIA; LUCIFERASES; MICE; MICE, TRANSGENIC; OXYGEN; OXYGEN INHALATION THERAPY; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 79953161682     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.02.113     Document Type: Article

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